Detailed information NTG0238996

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: QMA0248_RS06425
• Genome accession: NZ_CP022392
• Coordinates: 1323723..1324448 (-)
• Length: 241 a.a.
• NCBI ID: WP_003101290.1
• Uniprot ID: A0A3L8GIX6
• Organism: Streptococcus iniae strain QMA0248
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1318723..1329448

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QMA0248_RS06400 (QMA0248_1296)	-	1319034..1319645 (-)	612	WP_016356076.1	phosphate ABC transporter ATP-binding protein	-
QMA0248_RS06405 (QMA0248_1297)	pstA	1319648..1320463 (-)	816	WP_003101283.1	phosphate ABC transporter permease PstA	-
QMA0248_RS06410 (QMA0248_1298)	pstC	1320456..1321319 (-)	864	WP_003101285.1	phosphate ABC transporter permease subunit PstC	-
QMA0248_RS06415 (QMA0248_1299)	-	1321382..1322257 (-)	876	WP_003101287.1	substrate-binding domain-containing protein	-
QMA0248_RS06420 (QMA0248_1300)	pnpS	1322411..1323739 (-)	1329	WP_003101288.1	two-component system histidine kinase PnpS	-
QMA0248_RS06425 (QMA0248_1301)	vicR	1323723..1324448 (-)	726	WP_003101290.1	response regulator transcription factor	Regulator
QMA0248_RS06430 (QMA0248_1302)	-	1324544..1324927 (-)	384	WP_003101292.1	VOC family protein	-
QMA0248_RS06435 (QMA0248_1303)	-	1325120..1325263 (+)	144	WP_003101294.1	SPJ_0845 family protein	-
QMA0248_RS06440 (QMA0248_1304)	-	1325263..1326168 (+)	906	WP_003101296.1	permease	-
QMA0248_RS06445 (QMA0248_1305)	-	1326165..1326980 (+)	816	WP_003101297.1	TIGR03943 family putative permease subunit	-
QMA0248_RS06450 (QMA0248_1306)	-	1327052..1327678 (-)	627	WP_003101299.1	NAD-dependent epimerase/dehydratase family protein	-
QMA0248_RS06455 (QMA0248_1308)	-	1327986..1329362 (-)	1377	WP_003101303.1	PTS sugar transporter subunit IIC	-

Sequence

Protein

• Length: 241 a.a.
• Molecular weight: 28088.34 Da
• Isoelectric Point: 5.1365

>NTDB_id=238996 QMA0248_RS06425 WP_003101290.1 1323723..1324448(-) (vicR) [Streptococcus iniae strain QMA0248]
MKKTVLLVDDEEHILRLLDYHLSKEGFSIDTATDGRSALKLAETESYDFILLDIMLPQLDGIEVCKRIRAKNSKTPIMMV
SAKGEEFDKVLALELGADDYMTKPFSPRELLARVKAILRRTGKDDSQQEEFGFADQRFLVNDLVIYPERNEVYKEQDLIS
LTPKEYELLMYLVKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLRDKIEDDPKNPEMIKTIRGYGYQFKEMKDATK
S

Nucleotide

• Length: 726 bp

>NTDB_id=238996 QMA0248_RS06425 WP_003101290.1 1323723..1324448(-) (vicR) [Streptococcus iniae strain QMA0248]
ATGAAAAAGACAGTTTTATTAGTAGACGACGAAGAGCACATCTTACGTTTATTAGACTATCATCTCAGCAAGGAAGGCTT
TAGTATTGACACAGCAACAGATGGCAGATCAGCACTAAAATTAGCTGAAACAGAAAGTTATGACTTCATTTTGTTAGACA
TCATGTTGCCCCAATTGGACGGTATTGAGGTCTGTAAACGTATCAGAGCTAAAAATAGTAAGACCCCTATTATGATGGTA
TCAGCTAAAGGGGAAGAATTTGACAAGGTCCTAGCCTTAGAACTAGGAGCTGATGATTACATGACAAAACCCTTTAGTCC
AAGGGAATTGCTGGCGCGTGTAAAAGCTATTTTAAGACGAACAGGAAAAGACGACAGCCAACAAGAAGAGTTTGGCTTCG
CTGACCAGCGATTCTTGGTCAATGACTTGGTCATTTACCCTGAAAGAAATGAAGTTTACAAAGAGCAAGACTTGATTTCC
TTAACCCCAAAAGAGTATGAACTGTTAATGTATTTAGTCAAACATCCCAATATGACCTTAACAAGAGAACGACTTTTAGA
ACGGATTTGGGGGTATGACTTTGGCCAAGAAACACGTTTAGTAGATGTTCATATTGGAAAATTAAGAGACAAAATTGAAG
ATGATCCTAAAAATCCAGAGATGATTAAAACAATCAGGGGCTATGGCTATCAGTTTAAGGAGATGAAGGATGCTACAAAA
TCTTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (159-232)

3D structure

• AlphaFold DB: A0A3L8GIX6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	51.293	96.266	0.494
micA	Streptococcus pneumoniae Cp1015	48.918	95.851	0.469
covR	Lactococcus lactis subsp. lactis strain DGCC12653	42.194	98.34	0.415
covR	Streptococcus salivarius strain HSISS4	39.316	97.095	0.382