Detailed information NTG0023834

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: M6_RS09120
• Genome accession: NC_006086
• Coordinates: 1833940..1836495 (-)
• Length: 851 a.a.
• NCBI ID: WP_011185079.1
• Uniprot ID: A2RGX2
• Organism: Streptococcus pyogenes MGAS10394
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1828940..1841495

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M6_RS09920 (M6_Spy1818)	-	1830002..1830175 (+)	174	WP_000694577.1	hypothetical protein	-
M6_RS10165 (M6_Spy1819)	-	1830181..1830354 (+)	174	WP_011185075.1	hypothetical protein	-
M6_RS09095 (M6_Spy1820)	-	1830356..1830865 (+)	510	WP_011185076.1	hypothetical protein	-
M6_RS09100 (M6_Spy1821)	-	1830940..1831428 (+)	489	WP_002992480.1	hypothetical protein	-
M6_RS09105 (M6_Spy1822)	-	1831832..1832194 (+)	363	WP_002992136.1	DUF1492 domain-containing protein	-
M6_RS09110 (M6_Spy1823)	-	1832169..1832552 (+)	384	WP_011185077.1	ArpU family phage packaging/lysis transcriptional regulator	-
M6_RS09115 (M6_Spy1824)	-	1832753..1833358 (+)	606	WP_011185078.1	hypothetical protein	-
M6_RS09120 (M6_Spy1825)	hexA	1833940..1836495 (-)	2556	WP_011185079.1	DNA mismatch repair protein MutS	Machinery gene
M6_RS10410	-	1836482..1836835 (-)	354	Protein_1775	YlbF family regulator	-
M6_RS09125 (M6_Spy1826)	argR	1836832..1837269 (-)	438	WP_011185080.1	arginine repressor	-
M6_RS09130 (M6_Spy1827)	argS	1837560..1839251 (+)	1692	WP_011185081.1	arginine--tRNA ligase	-
M6_RS09135 (M6_Spy1828)	-	1839339..1839647 (+)	309	WP_011889238.1	bacteriocin immunity protein	-
M6_RS09140 (M6_Spy1829)	-	1839674..1840546 (-)	873	WP_011185083.1	YitT family protein	-
M6_RS09145 (M6_Spy1830)	-	1840589..1841467 (-)	879	WP_011889240.1	YitT family protein	-

Sequence

Protein

• Length: 851 a.a.
• Molecular weight: 95445.04 Da
• Isoelectric Point: 4.9823

>NTDB_id=23834 M6_RS09120 WP_011185079.1 1833940..1836495(-) (hexA) [Streptococcus pyogenes MGAS10394]
MAKTNISPGMQQYLDIKKDYPDAFLLFRMGDFYELFYDDAVKAAQLLEIGLTSRNKNAENPIPMAGVPHHSAQQYIDVLI
ELGYKVAVAEQMEDPKQAVGVVKREVVQVITPGTVVDSAKPDSANNFLVAVDFDGCRYGLAYMDVSTGEFCVTDLADFTS
VRSEIQNLKAKEVLLGFDLSEEEQTILVKQMNLLLSYEETVYEDKSLIDGQLTTVELTAAGKLLQYVHKTQMRELSHLQA
LVHYEIKDYLQMSYATKSSLDLVENARTNKKHGSLYWLLDETKTAMGMRLLRSWIDRPLVSKEAILERQEIIQVFLNAFI
ERTDLSNSLKGVYDIERLSSRVSFGKANPKDLLQLGHTLAQVPYIKAILESFDSPCVDKLVNDIDSLPELEYLIRTAIDP
DAPATISEGSIIRTGFDERLDHYRKVMREGTGWIADIEAKERQASGINNLKIDYNKKDGYYFHVTTSNLSLVPEHFFRKA
TLKNSERYGTAELAKIEGQMLEAREESSSLEYDIFMCIRAQVETYINRLQKLAKILATVDVLQSLAVVAETNHYIRPQFN
DNHVITIQEGRHAVVEKVMGVQEYIPNSISFDQQTSIQLITGPNMSGKSTYMRQLALTVIMAQMGSFVAADHVDLPLFDA
IFTRIGAADDLISGQSTFMVEMMEANQAIKRASDNSLILFDELGRGTATYDGMALAQAIIEYIHDRVGAKTIFATHYHEL
TDLSTKLTSLVNVHVATLEKDGDVTFLHKIAEGPADKSYGIHVAKIAGLPKSLLKRADEVLTRLETQSRSTEIMSVPPQV
ESSSAVRQGQLSLFGDEEKAHEIRQALEAIDVMNMTPLQAMTTLYELKKLL

Nucleotide

• Length: 2556 bp

>NTDB_id=23834 M6_RS09120 WP_011185079.1 1833940..1836495(-) (hexA) [Streptococcus pyogenes MGAS10394]
ATGGCAAAAACTAACATTTCTCCTGGAATGCAACAGTATCTGGACATCAAAAAAGATTATCCAGATGCTTTTTTGCTTTT
TAGGATGGGTGACTTTTATGAATTATTTTATGATGATGCTGTCAAAGCAGCACAACTCTTAGAAATTGGTTTGACCAGTC
GCAACAAGAATGCGGAAAATCCAATTCCCATGGCAGGCGTGCCACATCATTCTGCCCAACAATACATTGATGTGTTAATT
GAGTTGGGTTACAAGGTTGCTGTCGCAGAACAAATGGAAGACCCAAAGCAAGCTGTTGGGGTGGTGAAGCGTGAGGTCGT
TCAAGTCATAACTCCTGGAACGGTTGTGGATTCAGCTAAGCCAGATAGCGCCAATAACTTTTTGGTAGCTGTTGACTTTG
ATGGTTGCCGTTATGGATTGGCTTATATGGATGTATCCACAGGTGAATTTTGCGTGACAGATTTGGCGGACTTTACGAGT
GTTCGTAGCGAAATCCAAAACCTCAAGGCAAAAGAAGTCTTACTAGGTTTTGATTTATCTGAAGAAGAACAGACGATTTT
GGTCAAGCAGATGAATTTGCTGCTTTCTTATGAAGAAACGGTCTATGAAGATAAATCTTTAATTGACGGCCAATTGACAA
CGGTAGAACTGACAGCGGCAGGAAAACTCTTGCAATACGTTCACAAAACACAAATGCGAGAACTCAGCCACTTGCAAGCC
TTGGTTCACTATGAGATCAAGGATTATTTGCAGATGTCGTATGCCACTAAGTCAAGTTTAGATTTGGTAGAAAATGCTAG
GACTAATAAAAAACATGGAAGTCTCTATTGGCTGTTAGATGAAACCAAGACAGCTATGGGGATGAGGCTTTTGCGCTCAT
GGATTGATCGACCTTTGGTTTCTAAAGAAGCTATTTTAGAGCGTCAAGAAATTATTCAAGTTTTTCTGAATGCTTTTATT
GAGCGAACCGATTTAAGCAATAGTTTAAAAGGTGTTTACGACATCGAACGCTTATCTAGTCGCGTGTCTTTTGGTAAGGC
AAATCCGAAAGATTTACTTCAATTGGGGCATACCTTAGCCCAAGTGCCTTATATCAAAGCTATCTTAGAGTCTTTTGACA
GTCCTTGTGTTGACAAACTTGTCAATGATATTGACAGTTTGCCTGAGTTGGAATACTTGATTAGAACAGCCATTGATCCA
GATGCACCAGCAACTATTAGTGAAGGCAGTATTATTCGTACTGGTTTTGATGAGCGCTTGGACCATTATCGTAAAGTGAT
GCGAGAAGGAACAGGTTGGATTGCGGATATTGAGGCTAAAGAGCGTCAAGCAAGCGGCATTAATAACCTAAAAATTGATT
ACAATAAAAAAGATGGTTATTATTTTCACGTTACGACTTCAAATCTTAGCTTAGTTCCCGAGCATTTTTTCAGAAAGGCA
ACTTTAAAAAATTCTGAGCGTTATGGAACAGCAGAATTGGCTAAGATTGAAGGTCAGATGTTAGAGGCTAGGGAAGAGTC
ATCTAGTTTAGAATACGATATTTTTATGTGTATTCGAGCTCAAGTTGAAACCTATATTAATCGTTTACAGAAACTGGCTA
AAATTTTGGCAACGGTAGATGTTTTGCAAAGTTTAGCAGTCGTTGCTGAAACCAATCATTATATCCGGCCGCAGTTCAAT
GATAATCATGTGATTACAATTCAAGAAGGTCGTCACGCGGTTGTTGAAAAGGTTATGGGAGTGCAGGAATACATTCCCAA
TAGTATCTCTTTTGACCAACAGACCAGTATTCAGCTGATTACAGGTCCAAATATGAGTGGTAAGTCGACTTATATGAGAC
AGCTGGCCTTAACGGTTATCATGGCCCAGATGGGTTCATTTGTGGCTGCTGACCATGTTGATTTACCTTTATTTGATGCG
ATTTTTACGCGTATTGGGGCTGCTGATGATTTGATTTCTGGGCAATCAACCTTTATGGTGGAGATGATGGAAGCAAACCA
AGCAATCAAACGCGCAAGTGACAACTCTCTTATTCTATTTGATGAACTGGGACGAGGTACGGCAACTTATGACGGTATGG
CTTTAGCCCAGGCAATTATTGAATATATCCATGATAGAGTTGGTGCTAAGACCATATTTGCAACGCATTATCATGAATTG
ACAGACTTGTCAACTAAGTTGACAAGTCTAGTCAATGTTCATGTAGCAACGCTTGAAAAAGATGGCGATGTTACCTTCCT
TCATAAGATTGCTGAGGGACCGGCGGATAAATCTTACGGTATTCATGTTGCAAAAATAGCAGGACTGCCAAAATCCCTAT
TAAAGAGAGCAGACGAAGTTCTGACCCGTTTAGAAACACAGTCACGATCTACTGAGATAATGTCAGTCCCTCCACAAGTT
GAGTCAAGCAGCGCTGTTAGACAGGGGCAATTATCCCTTTTTGGTGATGAAGAGAAAGCTCATGAGATTAGGCAAGCACT
GGAAGCTATTGATGTCATGAATATGACCCCGCTTCAAGCAATGACAACCCTTTACGAATTGAAAAAGTTGTTATAG

Domains

Predicted by InterProScan.

• MutS domain II (MutS_II) (126-239)

• MutS domain III (MutS_III) (256-546)

• MutS family domain IV (MutS_IV) (415-506)

• MutS domain I (MutS_I) (8-118)

• MutS domain V (MutS_V) (599-785)

3D structure

• AlphaFold DB: A2RGX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	71.445	100	0.714
mutS	Pseudomonas stutzeri strain ATCC 17587	37.427	100	0.376