Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   M6_RS00570 Genome accession   NC_006086
Coordinates   94131..95042 (+) Length   303 a.a.
NCBI ID   WP_002986681.1    Uniprot ID   -
Organism   Streptococcus pyogenes MGAS10394     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 89131..100042
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M6_RS00550 (M6_Spy0079) purE 89580..90071 (+) 492 WP_021340277.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  M6_RS00555 (M6_Spy0080) purK 90058..91131 (+) 1074 WP_011888523.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  M6_RS00560 (M6_Spy0081) - 91152..92492 (+) 1341 WP_011184068.1 hypothetical protein -
  M6_RS00565 (M6_Spy0082) purB 92708..94000 (+) 1293 WP_011184069.1 adenylosuccinate lyase -
  M6_RS00570 (M6_Spy0083) comR 94131..95042 (+) 912 WP_002986681.1 transcriptional regulator Rgg4/ComR Regulator
  M6_RS10415 comS 95126..95221 (+) 96 WP_198462994.1 quorum-sensing system DWW-type pheromone Regulator
  M6_RS00575 (M6_Spy0084) ruvB 95268..96266 (+) 999 WP_002986679.1 Holliday junction branch migration DNA helicase RuvB -
  M6_RS00580 (M6_Spy0085) - 96404..96841 (+) 438 WP_002994668.1 low molecular weight protein-tyrosine-phosphatase -
  M6_RS00585 (M6_Spy0086) - 96864..97265 (+) 402 WP_002986671.1 MORN repeat-containing protein -
  M6_RS00590 (M6_Spy0087) - 97262..99037 (+) 1776 WP_011184071.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35757.27 Da        Isoelectric Point: 4.4858

>NTDB_id=23423 M6_RS00570 WP_002986681.1 94131..95042(+) (comR) [Streptococcus pyogenes MGAS10394]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 912 bp        

>NTDB_id=23423 M6_RS00570 WP_002986681.1 94131..95042(+) (comR) [Streptococcus pyogenes MGAS10394]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(12-64)

ComR tetratricopeptide (ComR_TPR)

(73-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

100

100

1
  comR Streptococcus pyogenes MGAS315

58.472

99.34

0.581
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

51.37

96.37

0.495
  comR Streptococcus mutans UA159

46.358

99.67

0.462

Multiple sequence alignment