Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   SPS_RS08350 Genome accession   NC_004606
Coordinates   1612428..1613114 (-) Length   228 a.a.
NCBI ID   WP_011106890.1    Uniprot ID   -
Organism   Streptococcus pyogenes SSI-1     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1607428..1618114
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPS_RS08330 (SPs1611) dnaI 1608149..1609051 (-) 903 WP_002991016.1 primosomal protein DnaI -
  SPS_RS08335 (SPs1612) - 1609052..1610227 (-) 1176 WP_011054202.1 replication initiation and membrane attachment family protein -
  SPS_RS08340 nrdR 1610211..1610705 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  SPS_RS08345 (SPs1614) covS 1610920..1612422 (-) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  SPS_RS08350 (SPs1615) covR 1612428..1613114 (-) 687 WP_011106890.1 two-component system response regulator CovR Regulator
  SPS_RS08355 (SPs1616) - 1613382..1613915 (-) 534 WP_011054200.1 YceD family protein -
  SPS_RS08360 (SPs1617) htpX 1614149..1615045 (-) 897 WP_011054199.1 zinc metalloprotease HtpX -
  SPS_RS08365 (SPs1618) - 1615092..1615649 (-) 558 WP_011106891.1 LemA family protein -
  SPS_RS08370 (SPs1619) rsmG 1615799..1616512 (+) 714 WP_011054198.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  SPS_RS08375 (SPs1620) ktrB 1616596..1617972 (+) 1377 WP_032461391.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26565.65 Da        Isoelectric Point: 4.5945

>NTDB_id=22822 SPS_RS08350 WP_011106890.1 1612428..1613114(-) (covR) [Streptococcus pyogenes SSI-1]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFCRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=22822 SPS_RS08350 WP_011106890.1 1612428..1613114(-) (covR) [Streptococcus pyogenes SSI-1]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGGTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCTGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

81.659

100

0.82
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.52

99.561

0.662
  vicR Streptococcus mutans UA159

43.534

100

0.443
  micA Streptococcus pneumoniae Cp1015

41.739

100

0.421

Multiple sequence alignment