Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   SE_RS00185 Genome accession   NC_004461
Coordinates   44091..45440 (-) Length   449 a.a.
NCBI ID   WP_011082535.1    Uniprot ID   -
Organism   Staphylococcus epidermidis ATCC 12228     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 42462..66000 44091..45440 within 0


Gene organization within MGE regions


Location: 42462..66000
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SE_RS00185 (SE0037) ccrA 44091..45440 (-) 1350 WP_011082535.1 cassette chromosome recombinase CcrA Machinery gene
  SE_RS00190 (SE0038) cch1 45674..47467 (-) 1794 WP_011082536.1 cassette chromosome replicative helicase -
  SE_RS00195 (SE0039) ssb 47467..47763 (-) 297 WP_011082537.1 cassette chromosome ssDNA-binding protein -
  SE_RS00200 (SE0040) - 47956..49002 (-) 1047 WP_001042023.1 hypothetical protein -
  SE_RS00205 (SE0041) - 49457..50611 (+) 1155 WP_011082538.1 ATP-binding protein -
  SE_RS00210 (SE0042) - 50641..51441 (+) 801 WP_000749912.1 abortive infection family protein -
  SE_RS00215 (SE0043) - 51626..51769 (+) 144 WP_001631028.1 restriction endonuclease subunit R -
  SE_RS00220 (SE0044) - 51762..52964 (+) 1203 WP_001631029.1 restriction endonuclease subunit S -
  SE_RS00225 (SE0045) - 52968..53228 (-) 261 Protein_42 IS5/IS1182 family transposase -
  SE_RS00230 (SE0046) - 53287..53784 (-) 498 WP_001631030.1 GNAT family N-acetyltransferase -
  SE_RS00235 (SE0048) - 54456..54866 (-) 411 WP_001631031.1 DUF2871 domain-containing protein -
  SE_RS00240 - 55029..55249 (-) 221 Protein_45 hypothetical protein -
  SE_RS00245 (SE0050) - 55264..55506 (-) 243 Protein_46 DUF1643 domain-containing protein -
  SE_RS00250 (SE0051) - 55611..56810 (-) 1200 WP_080033508.1 IS110-like element ISSep2 family transposase -
  SE_RS00255 (SE0052) - 57031..57327 (-) 297 Protein_48 DUF1643 domain-containing protein -
  SE_RS00260 (SE0053) - 57343..57654 (-) 312 WP_002501910.1 DUF960 family protein -
  SE_RS00265 (SE0055) - 57741..58091 (-) 351 WP_002485722.1 SAUGI family uracil-DNA glycosylase inhibitor -
  SE_RS00270 (SE0056) ccrB 58592..60220 (-) 1629 WP_011082541.1 cassette chromosome recombinase CcrB Machinery gene
  SE_RS00275 (SE0057) ccrA 60217..61578 (-) 1362 WP_001631036.1 cassette chromosome recombinase CcrA Machinery gene
  SE_RS00280 (SE0058) - 61765..62394 (-) 630 Protein_53 hypothetical protein -
  SE_RS00285 - 62403..62741 (+) 339 Protein_54 recombinase family protein -
  SE_RS00290 (SE0060) - 62853..63212 (-) 360 WP_001631039.1 hypothetical protein -
  SE_RS00295 - 63419..63745 (+) 327 WP_000391495.1 ArsR/SmtB family transcription factor -
  SE_RS00300 (SE0062) - 64075..66000 (+) 1926 WP_002485723.1 heavy metal translocating P-type ATPase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52539.11 Da        Isoelectric Point: 9.9639

>NTDB_id=22562 SE_RS00185 WP_011082535.1 44091..45440(-) (ccrA) [Staphylococcus epidermidis ATCC 12228]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQVTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYDYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQTKQTSSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHILTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQAMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=22562 SE_RS00185 WP_011082535.1 44091..45440(-) (ccrA) [Staphylococcus epidermidis ATCC 12228]
ATGAAACAAGTTATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAGTAACACAATTAATTCAACAAGGACAATGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGATTATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGTCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAACCAAACAGACATCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACATATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATAAATGGGCATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAGCCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(169-250)

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

97.773

100

0.978
  ccrA Staphylococcus aureus COL

75.056

100

0.751

Multiple sequence alignment