Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   SE_RS00275 Genome accession   NC_004461
Coordinates   60217..61578 (-) Length   453 a.a.
NCBI ID   WP_001631036.1    Uniprot ID   -
Organism   Staphylococcus epidermidis ATCC 12228     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 42462..66000 60217..61578 within 0


Gene organization within MGE regions


Location: 42462..66000
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SE_RS00185 (SE0037) ccrA 44091..45440 (-) 1350 WP_011082535.1 cassette chromosome recombinase CcrA Machinery gene
  SE_RS00190 (SE0038) cch1 45674..47467 (-) 1794 WP_011082536.1 cassette chromosome replicative helicase -
  SE_RS00195 (SE0039) ssb 47467..47763 (-) 297 WP_011082537.1 cassette chromosome ssDNA-binding protein -
  SE_RS00200 (SE0040) - 47956..49002 (-) 1047 WP_001042023.1 hypothetical protein -
  SE_RS00205 (SE0041) - 49457..50611 (+) 1155 WP_011082538.1 ATP-binding protein -
  SE_RS00210 (SE0042) - 50641..51441 (+) 801 WP_000749912.1 abortive infection family protein -
  SE_RS00215 (SE0043) - 51626..51769 (+) 144 WP_001631028.1 restriction endonuclease subunit R -
  SE_RS00220 (SE0044) - 51762..52964 (+) 1203 WP_001631029.1 restriction endonuclease subunit S -
  SE_RS00225 (SE0045) - 52968..53228 (-) 261 Protein_42 IS5/IS1182 family transposase -
  SE_RS00230 (SE0046) - 53287..53784 (-) 498 WP_001631030.1 GNAT family N-acetyltransferase -
  SE_RS00235 (SE0048) - 54456..54866 (-) 411 WP_001631031.1 DUF2871 domain-containing protein -
  SE_RS00240 - 55029..55249 (-) 221 Protein_45 hypothetical protein -
  SE_RS00245 (SE0050) - 55264..55506 (-) 243 Protein_46 DUF1643 domain-containing protein -
  SE_RS00250 (SE0051) - 55611..56810 (-) 1200 WP_080033508.1 IS110-like element ISSep2 family transposase -
  SE_RS00255 (SE0052) - 57031..57327 (-) 297 Protein_48 DUF1643 domain-containing protein -
  SE_RS00260 (SE0053) - 57343..57654 (-) 312 WP_002501910.1 DUF960 family protein -
  SE_RS00265 (SE0055) - 57741..58091 (-) 351 WP_002485722.1 SAUGI family uracil-DNA glycosylase inhibitor -
  SE_RS00270 (SE0056) ccrB 58592..60220 (-) 1629 WP_011082541.1 cassette chromosome recombinase CcrB Machinery gene
  SE_RS00275 (SE0057) ccrA 60217..61578 (-) 1362 WP_001631036.1 cassette chromosome recombinase CcrA Machinery gene
  SE_RS00280 (SE0058) - 61765..62394 (-) 630 Protein_53 hypothetical protein -
  SE_RS00285 - 62403..62741 (+) 339 Protein_54 recombinase family protein -
  SE_RS00290 (SE0060) - 62853..63212 (-) 360 WP_001631039.1 hypothetical protein -
  SE_RS00295 - 63419..63745 (+) 327 WP_000391495.1 ArsR/SmtB family transcription factor -
  SE_RS00300 (SE0062) - 64075..66000 (+) 1926 WP_002485723.1 heavy metal translocating P-type ATPase -

Sequence

Protein


Download         Length: 453 a.a.        Molecular weight: 53316.45 Da        Isoelectric Point: 9.8596

>NTDB_id=22564 SE_RS00275 WP_001631036.1 60217..61578(-) (ccrA) [Staphylococcus epidermidis ATCC 12228]
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI

Nucleotide


Download         Length: 1362 bp        

>NTDB_id=22564 SE_RS00275 WP_001631036.1 60217..61578(-) (ccrA) [Staphylococcus epidermidis ATCC 12228]
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase (Recombinase)

(168-248)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

54.628

97.792

0.534
  ccrA Staphylococcus aureus N315

50.564

97.792

0.494

Multiple sequence alignment