Detailed information NTG0022563

Bioinformatically predicted

Overview

• Name: ccrB
• Type: Machinery gene
• Locus tag: SE_RS00270
• Genome accession: NC_004461
• Coordinates: 58592..60220 (-)
• Length: 542 a.a.
• NCBI ID: WP_011082541.1
• Uniprot ID: Q8CQJ0
• Organism: Staphylococcus epidermidis ATCC 12228
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	42462..66000	58592..60220	within	0

Gene organization within MGE regions

Location: 42462..66000

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SE_RS00185 (SE0037)	ccrA	44091..45440 (-)	1350	WP_011082535.1	cassette chromosome recombinase CcrA	Machinery gene
SE_RS00190 (SE0038)	cch1	45674..47467 (-)	1794	WP_011082536.1	cassette chromosome replicative helicase	-
SE_RS00195 (SE0039)	ssb	47467..47763 (-)	297	WP_011082537.1	cassette chromosome ssDNA-binding protein	-
SE_RS00200 (SE0040)	-	47956..49002 (-)	1047	WP_001042023.1	hypothetical protein	-
SE_RS00205 (SE0041)	-	49457..50611 (+)	1155	WP_011082538.1	ATP-binding protein	-
SE_RS00210 (SE0042)	-	50641..51441 (+)	801	WP_000749912.1	abortive infection family protein	-
SE_RS00215 (SE0043)	-	51626..51769 (+)	144	WP_001631028.1	restriction endonuclease subunit R	-
SE_RS00220 (SE0044)	-	51762..52964 (+)	1203	WP_001631029.1	restriction endonuclease subunit S	-
SE_RS00225 (SE0045)	-	52968..53228 (-)	261	Protein_42	IS5/IS1182 family transposase	-
SE_RS00230 (SE0046)	-	53287..53784 (-)	498	WP_001631030.1	GNAT family N-acetyltransferase	-
SE_RS00235 (SE0048)	-	54456..54866 (-)	411	WP_001631031.1	DUF2871 domain-containing protein	-
SE_RS00240	-	55029..55249 (-)	221	Protein_45	hypothetical protein	-
SE_RS00245 (SE0050)	-	55264..55506 (-)	243	Protein_46	DUF1643 domain-containing protein	-
SE_RS00250 (SE0051)	-	55611..56810 (-)	1200	WP_080033508.1	IS110-like element ISSep2 family transposase	-
SE_RS00255 (SE0052)	-	57031..57327 (-)	297	Protein_48	DUF1643 domain-containing protein	-
SE_RS00260 (SE0053)	-	57343..57654 (-)	312	WP_002501910.1	DUF960 family protein	-
SE_RS00265 (SE0055)	-	57741..58091 (-)	351	WP_002485722.1	SAUGI family uracil-DNA glycosylase inhibitor	-
SE_RS00270 (SE0056)	ccrB	58592..60220 (-)	1629	WP_011082541.1	cassette chromosome recombinase CcrB	Machinery gene
SE_RS00275 (SE0057)	ccrA	60217..61578 (-)	1362	WP_001631036.1	cassette chromosome recombinase CcrA	Machinery gene
SE_RS00280 (SE0058)	-	61765..62394 (-)	630	Protein_53	hypothetical protein	-
SE_RS00285	-	62403..62741 (+)	339	Protein_54	recombinase family protein	-
SE_RS00290 (SE0060)	-	62853..63212 (-)	360	WP_001631039.1	hypothetical protein	-
SE_RS00295	-	63419..63745 (+)	327	WP_000391495.1	ArsR/SmtB family transcription factor	-
SE_RS00300 (SE0062)	-	64075..66000 (+)	1926	WP_002485723.1	heavy metal translocating P-type ATPase	-

Sequence

Protein

• Length: 542 a.a.
• Molecular weight: 62532.74 Da
• Isoelectric Point: 9.5610

>NTDB_id=22563 SE_RS00270 WP_011082541.1 58592..60220(-) (ccrB) [Staphylococcus epidermidis ATCC 12228]
MKQLKKKRIGLYARVSTEMQTDGYSIQGQLNQLTEYCQFQGYEVVNEYTDRGISGKTMQRPELQRMLKDANEGKLDCIMV
YKTNRLARNTSDLLNIVEELYKINVEFFSLTEKIEIASSTGKLMLQILASFAEFERNTIVENVYNGQRQRAIEGYYQGNL
PLGYDKVPDSKKELMINQHEANIVKYIFDSYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYIISNPFYIGKIQFAKY
RHWSDKRRKGLNEEPIIADGKHAPIIDRNLWDKVQFKRQESRKKPQVHGKGTNLLTGIVKCPKCGAAMEASNTTNTLKDG
TKKRIRYYSCSNFRNKGSKVCSANSVRADVLEKYVMDQILEIIKSKKVLKQLVEKVNEKSQIDVSSLNHDIAYKQSQCEE
IKAKMHTLTKTIEDSPDLDSVLKPTILSYQDELNQINNQIYQLEQDKQAEAPHYDADMIANVLQAIFKDIDKLEKSQLKS
LYLTIIDRIDIRKDEHHKKQFYVTLKLNNDIIKQLFNNHPLDEVLPSTSSLFLPQTLYITIE

Nucleotide

• Length: 1629 bp

>NTDB_id=22563 SE_RS00270 WP_011082541.1 58592..60220(-) (ccrB) [Staphylococcus epidermidis ATCC 12228]
ATGAAACAACTCAAAAAGAAACGTATTGGATTATATGCACGTGTATCGACTGAAATGCAAACGGATGGTTACAGTATTCA
AGGTCAATTGAATCAACTTACAGAGTATTGTCAATTTCAAGGCTATGAAGTCGTCAATGAATACACCGATCGTGGTATAT
CAGGTAAAACAATGCAACGTCCAGAATTACAACGTATGTTAAAAGATGCCAACGAAGGTAAATTAGATTGTATTATGGTC
TACAAAACAAATCGTTTAGCTAGAAATACCTCAGATTTGTTAAATATTGTCGAGGAATTGTATAAGATTAATGTCGAATT
TTTTAGTCTAACTGAAAAAATAGAAATTGCCAGTTCAACAGGTAAATTGATGCTCCAAATTTTAGCCAGCTTCGCAGAAT
TTGAACGTAATACGATTGTAGAGAATGTCTACAATGGCCAAAGACAACGTGCTATTGAAGGTTATTATCAAGGTAATTTA
CCTCTAGGCTACGATAAAGTACCTGACAGTAAAAAAGAGCTCATGATCAATCAACATGAAGCGAATATTGTTAAATATAT
TTTTGATTCATACGCTAAAGGTCATGGTTATCGTAAGATTGCGAACGCATTGAATCATAAAGGTTATGTGACTAAGAAAG
GGAAACCTTTTAGTATTTCGTCCATTACCTACATCATCTCAAACCCTTTTTACATTGGAAAGATACAGTTTGCGAAGTAT
AGACACTGGAGCGATAAAAGACGAAAAGGACTCAATGAGGAACCGATTATCGCTGATGGTAAACATGCGCCTATTATTGA
TAGAAACCTATGGGATAAAGTACAGTTTAAACGTCAAGAGAGTCGCAAGAAACCACAAGTTCACGGCAAAGGAACAAACC
TACTGACTGGGATTGTAAAATGTCCGAAATGTGGTGCAGCAATGGAGGCAAGTAATACAACTAATACATTAAAAGATGGC
ACTAAGAAAAGAATCAGATATTACTCATGTAGCAATTTTAGAAATAAAGGTTCAAAAGTTTGTTCTGCCAATAGCGTTAG
AGCAGATGTACTAGAAAAATATGTTATGGATCAGATATTGGAAATTATCAAAAGCAAAAAGGTATTGAAGCAATTGGTTG
AAAAGGTAAATGAAAAAAGTCAAATAGACGTCTCTTCTTTGAACCATGATATTGCCTATAAACAGTCACAATGTGAAGAA
ATAAAAGCAAAAATGCATACATTAACGAAAACTATTGAAGACTCACCTGACTTAGATAGCGTATTAAAACCAACAATACT
TAGCTACCAAGATGAATTGAATCAAATAAATAATCAAATCTATCAACTAGAACAAGATAAACAAGCAGAAGCTCCACATT
ATGATGCTGATATGATTGCGAATGTACTACAAGCAATATTCAAAGATATAGACAAATTAGAGAAATCTCAGTTGAAATCA
CTATATCTAACAATCATCGATCGCATTGACATAAGAAAAGATGAGCATCATAAGAAGCAATTTTATGTTACGCTCAAGTT
AAATAATGATATAATCAAACAACTATTTAATAACCATCCACTCGACGAAGTGCTCCCTAGCACTTCGTCTTTATTTTTGC
CACAAACTTTATATATAACTATTGAATAA

Domains

Predicted by InterproScan.

• Ogr/Delta-like zinc finger (Ogr_Delta) (300-355)

• Resolvase, N terminal domain (Resolvase) (11-154)

• Recombinase (Recombinase) (179-280)

3D structure

• AlphaFold DB: Q8CQJ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrB	Staphylococcus aureus N315	72.509	100	0.725