NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	CV83906_RS15215	Genome accession	NZ_CP025753
Coordinates	2758140..2758799 (-)	Length	219 a.a.
NCBI ID	WP_001221491.1	Uniprot ID	-
Organism	Escherichia coli strain CV839-06
Function	repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 2753140..2763799

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CV83906_RS15185 (CV83906_2733)	-	2753344..2754096 (-)	753	WP_000619462.1	GntR family transcriptional regulator	-
CV83906_RS15195 (CV83906_2735)	-	2754383..2755714 (+)	1332	WP_000778883.1	MFS transporter	-
CV83906_RS15200 (CV83906_2736)	ygiN	2755758..2756072 (-)	315	WP_000958598.1	putative quinol monooxygenase	-
CV83906_RS15205 (CV83906_2737)	mdaB	2756103..2756684 (-)	582	WP_000065430.1	NADPH:quinone oxidoreductase MdaB	-
CV83906_RS15210 (CV83906_2738)	qseC	2756794..2758143 (-)	1350	WP_000673406.1	quorum sensing histidine kinase QseC	-
CV83906_RS15215 (CV83906_2739)	ciaR	2758140..2758799 (-)	660	WP_001221491.1	quorum sensing response regulator transcription factor QseB	Regulator
CV83906_RS15220 (CV83906_2740)	ygiW	2758951..2759343 (+)	393	WP_000712658.1	OB fold stress tolerance protein YgiW	-
CV83906_RS15225 (CV83906_2741)	ygiV	2759396..2759878 (+)	483	WP_000183498.1	GyrI-like domain-containing protein	-
CV83906_RS15230	mqsR	2760083..2760379 (+)	297	WP_000415584.1	type II toxin-antitoxin system toxin MqsR	-
CV83906_RS15235 (CV83906_2742)	mqsA	2760381..2760776 (+)	396	WP_000650107.1	type II toxin-antitoxin system antitoxin MqsA	-
CV83906_RS15245 (CV83906_2743)	ygiS	2760909..2762516 (+)	1608	WP_001324265.1	ABC transporter substrate-binding protein	-

Sequence

Protein

Download Length: 219 a.a. Molecular weight: 24745.66 Da Isoelectric Point: 6.6540

                                >NTDB_id=219872 CV83906_RS15215 WP_001221491.1 2758140..2758799(-) (ciaR) [Escherichia coli strain CV839-06]

MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA

RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPDKRIATLAGEPLTLKPKEFALLEL

LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide

Download Length: 660 bp

                                >NTDB_id=219872 CV83906_RS15215 WP_001221491.1 2758140..2758799(-) (ciaR) [Escherichia coli strain CV839-06]

ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT

CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT

TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG

CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA

AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC

TCGACCCCGACAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA

CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG

TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT

ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus pneumoniae Rx1	38.326	100	0.397
ciaR	Streptococcus pneumoniae D39	38.326	100	0.397
ciaR	Streptococcus pneumoniae R6	38.326	100	0.397
ciaR	Streptococcus pneumoniae TIGR4	38.326	100	0.397
ciaR	Streptococcus mutans UA159	35.874	100	0.365
micA	Streptococcus pneumoniae Cp1015	34.498	100	0.361

Detailed information NTG0219872