Detailed information NTG0216334

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: BWR56_RS07915
• Genome accession: NZ_CP019562
• Coordinates: 1612961..1613698 (-)
• Length: 245 a.a.
• NCBI ID: WP_049505121.1
• Uniprot ID: -
• Organism: Streptococcus oralis strain S.MIT/ORALIS-351
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1607961..1618698

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BWR56_RS07880 (BWR56_1563)	blpZ	1608275..1608523 (-)	249	WP_049505111.1	immunity protein BlpZ	-
BWR56_RS07885 (BWR56_1564)	-	1608565..1609254 (-)	690	WP_049505112.1	CPBP family intramembrane glutamic endopeptidase	-
BWR56_RS07890 (BWR56_1565)	-	1609306..1609689 (-)	384	WP_049505114.1	hypothetical protein	-
BWR56_RS07895 (BWR56_1566)	-	1609761..1610165 (-)	405	WP_049505115.1	hypothetical protein	-
BWR56_RS07900 (BWR56_1567)	-	1610226..1610894 (-)	669	WP_049505117.1	CPBP family intramembrane glutamic endopeptidase	-
BWR56_RS07905	-	1611173..1611529 (-)	357	WP_049505118.1	hypothetical protein	-
BWR56_RS07910 (BWR56_1568)	-	1611598..1612947 (-)	1350	WP_049505119.1	sensor histidine kinase	-
BWR56_RS07915 (BWR56_1569)	comE/blpR	1612961..1613698 (-)	738	WP_049505121.1	response regulator transcription factor	Regulator
BWR56_RS07920 (BWR56_1570)	-	1613703..1614041 (-)	339	WP_049505123.1	LytTR family DNA-binding domain-containing protein	-
BWR56_RS07925 (BWR56_1571)	-	1614320..1614649 (+)	330	WP_049505124.1	hypothetical protein	-
BWR56_RS07930 (BWR56_1572)	-	1614798..1615847 (-)	1050	WP_049505126.1	ABC transporter permease	-
BWR56_RS07935 (BWR56_1573)	pptA	1615844..1616575 (-)	732	WP_049505127.1	ABC transporter ATP-binding protein	Regulator
BWR56_RS07940 (BWR56_1574)	-	1616643..1617053 (+)	411	WP_001278305.1	HIT family protein	-
BWR56_RS07945 (BWR56_1575)	-	1617063..1617350 (+)	288	WP_049505129.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28743.95 Da
• Isoelectric Point: 6.5015

>NTDB_id=216334 BWR56_RS07915 WP_049505121.1 1612961..1613698(-) (comE/blpR) [Streptococcus oralis strain S.MIT/ORALIS-351]
MRIFVLEDDFSQQARIETTIEKLLKKQSIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVRLDKKEKLLYFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=216334 BWR56_RS07915 WP_049505121.1 1612961..1613698(-) (comE/blpR) [Streptococcus oralis strain S.MIT/ORALIS-351]
ATGAGAATATTTGTTTTAGAAGATGACTTTTCCCAACAAGCTAGAATTGAAACGACGATTGAGAAACTTTTGAAAAAACA
GAGTATCATTCCTAGTTCTTTTGAAGTCTTTGGGAAACCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGAGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAAGGTCTAGAGGTAGCTAGAAAGATTCGAGATCGGGAT
CCTTATGCCCTCATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAGGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAATTTGAGTCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGACA
GTAAGAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCTCAATTCCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCCAATGTAGTTCGTTTGGATA
AGAAAGAAAAACTGCTTTACTTTCCCAATGGTGGAAGTTGCCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	55.144	99.184	0.547
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	39.256	98.776	0.388