Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SPR_RS02375 Genome accession   NC_003098
Coordinates   469762..470499 (+) Length   245 a.a.
NCBI ID   WP_001219139.1    Uniprot ID   Q9F2F6
Organism   Streptococcus pneumoniae R6     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 464762..475499
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPR_RS02345 (spr0457) - 466094..466381 (-) 288 WP_000777760.1 hypothetical protein -
  SPR_RS02350 (spr0458) - 466391..466801 (-) 411 WP_001278301.1 HIT family protein -
  SPR_RS02355 (spr0459) pptA 466869..467600 (+) 732 WP_000889919.1 ABC transporter ATP-binding protein Regulator
  SPR_RS02360 (spr0460) - 467597..468646 (+) 1050 WP_000653770.1 ABC transporter permease -
  SPR_RS02365 (spr0461) - 468814..469143 (-) 330 WP_000132569.1 hypothetical protein -
  SPR_RS02370 (spr0462) - 469419..469757 (+) 339 WP_000682124.1 LytTR family DNA-binding domain-containing protein -
  SPR_RS02375 (spr0463) comE/blpR 469762..470499 (+) 738 WP_001219139.1 response regulator transcription factor Regulator
  SPR_RS02380 (spr0464) - 470513..471853 (+) 1341 WP_001017622.1 sensor histidine kinase -
  SPR_RS02385 (spr0465) blpC 471895..472050 (-) 156 WP_000358817.1 quorum-sensing system pheromone BlpC -
  SPR_RS02390 (spr0466) - 472107..473468 (-) 1362 Protein_465 bacteriocin secretion accessory protein -
  SPR_RS02395 (spr0468) comA/nlmT 473479..475155 (-) 1677 WP_306423909.1 peptide cleavage/export ABC transporter Regulator

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28814.94 Da        Isoelectric Point: 6.0454

>NTDB_id=21546 SPR_RS02375 WP_001219139.1 469762..470499(+) (comE/blpR) [Streptococcus pneumoniae R6]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITLSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=21546 SPR_RS02375 WP_001219139.1 469762..470499(+) (comE/blpR) [Streptococcus pneumoniae R6]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCTGAGTTCTTTTGAAGTTTTTGGTAAGCCAGATCAATTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-241)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9F2F6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.882

96.735

0.424
  comE/comE2 Streptococcus equinus JB1

38.843

98.776

0.384

Multiple sequence alignment