Detailed information NTG0210656

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: BTR42_RS11010
• Genome accession: NZ_CP018822
• Coordinates: 2214781..2215509 (-)
• Length: 242 a.a.
• NCBI ID: WP_012962512.1
• Uniprot ID: A0A139R4K2
• Organism: Streptococcus gallolyticus subsp. gallolyticus DSM 16831
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2209781..2220509

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BTR42_RS10975 (BTR42_10720)	-	2210385..2211014 (-)	630	WP_013643475.1	thiamine diphosphokinase	-
BTR42_RS10980 (BTR42_10725)	rpe	2211007..2211669 (-)	663	WP_013643476.1	ribulose-phosphate 3-epimerase	-
BTR42_RS10985 (BTR42_10730)	rsgA	2211676..2212548 (-)	873	WP_077497721.1	ribosome small subunit-dependent GTPase A	-
BTR42_RS11000 (BTR42_10740)	-	2213071..2213271 (-)	201	WP_077497723.1	bacteriocin	-
BTR42_RS11005 (BTR42_10745)	comD/comD3	2213404..2214768 (-)	1365	WP_077497726.1	sensor histidine kinase	Regulator
BTR42_RS11010 (BTR42_10750)	comE/comE2	2214781..2215509 (-)	729	WP_012962512.1	LytR/AlgR family response regulator transcription factor	Regulator
BTR42_RS11015 (BTR42_10755)	-	2215608..2215901 (-)	294	WP_009854994.1	bacteriocin immunity protein	-
BTR42_RS11020 (BTR42_10760)	-	2215952..2216104 (-)	153	WP_231873055.1	hypothetical protein	-
BTR42_RS11025 (BTR42_10765)	-	2216448..2216759 (-)	312	WP_003066564.1	bacteriocin immunity protein	-
BTR42_RS11030 (BTR42_10770)	-	2216771..2216920 (-)	150	WP_013643483.1	hypothetical protein	-
BTR42_RS11035 (BTR42_10775)	-	2216977..2217228 (-)	252	WP_231844599.1	DUF3884 family protein	-
BTR42_RS12705 (BTR42_10780)	-	2217529..2217669 (+)	141	WP_014295304.1	hypothetical protein	-
BTR42_RS11040 (BTR42_10785)	-	2217686..2218996 (-)	1311	WP_058621373.1	sensor histidine kinase	-
BTR42_RS11045 (BTR42_10790)	comE/comE1	2219001..2219732 (-)	732	WP_077497729.1	response regulator transcription factor	Regulator
BTR42_RS11050 (BTR42_10795)	-	2219749..2220075 (-)	327	WP_009855002.1	LytTR family DNA-binding domain-containing protein	-

Sequence

Protein

• Length: 242 a.a.
• Molecular weight: 28063.45 Da
• Isoelectric Point: 6.7499

>NTDB_id=210656 BTR42_RS11010 WP_012962512.1 2214781..2215509(-) (comE/comE2) [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
MIDIYVLEDDVNQQFRLEKMIDEVLVDNQWQHRCFELFGEPSRLITLIDETVPQIFFLDLDINGDKTKGIEVAKAIRDVS
KTATLVFVTTHSEFMLLTYRAQVSALDFIDKTDSDLAIKENLQACLKKVVEGQVPRLSLDTFIFENNKTKIRIPFEDILY
FETAEAHRLMLVTRTGQRNFYGTIREVKKANHKLFQCHKSYLINPDNVVSLDKKEGLVYFVGGKSCYVSKKHMKELKTKL
ES

Nucleotide

• Length: 729 bp

>NTDB_id=210656 BTR42_RS11010 WP_012962512.1 2214781..2215509(-) (comE/comE2) [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
ATGATTGATATTTATGTTTTGGAAGATGACGTAAATCAGCAGTTTCGCTTGGAAAAAATGATTGACGAGGTGCTTGTGGA
CAATCAGTGGCAACATCGTTGTTTTGAATTGTTTGGTGAGCCCAGTCGTCTTATCACTCTTATTGATGAAACGGTTCCTC
AAATCTTTTTCTTGGATTTGGATATCAATGGCGATAAAACGAAAGGAATTGAAGTTGCCAAGGCGATTAGAGACGTTTCG
AAAACAGCAACACTTGTCTTTGTTACAACGCATTCTGAATTTATGCTCCTGACCTATCGTGCGCAAGTCAGTGCCCTTGA
TTTCATTGATAAAACTGACAGTGACTTGGCAATCAAGGAAAATTTGCAGGCTTGTTTAAAGAAAGTCGTTGAAGGACAAG
TGCCTCGCCTAAGCTTGGATACCTTTATTTTTGAAAACAATAAAACTAAAATCAGAATACCGTTTGAAGATATTCTTTAT
TTTGAAACGGCGGAAGCGCACCGTTTGATGTTGGTGACACGGACAGGACAGCGTAATTTTTACGGAACAATTAGAGAAGT
TAAAAAGGCAAATCATAAGCTATTTCAATGCCATAAATCCTATCTGATTAATCCTGATAATGTCGTCAGTTTGGATAAAA
AAGAAGGGCTTGTTTATTTTGTAGGTGGAAAATCTTGCTACGTTTCCAAAAAACACATGAAAGAATTAAAAACTAAACTA
GAAAGTTAG

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-240)

• Response regulator receiver domain (Response_reg) (5-113)

3D structure

• AlphaFold DB: A0A139R4K2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus equinus JB1	70.248	100	0.702
comE/comE1	Streptococcus equinus JB1	43.802	100	0.438
comE/blpR	Streptococcus mutans UA159	42.739	99.587	0.426