Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   SPY_RS00295 Genome accession   NC_002737
Coordinates   52705..53616 (+) Length   303 a.a.
NCBI ID   WP_002986681.1    Uniprot ID   -
Organism   Streptococcus pyogenes M1 GAS     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 47705..58616
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPY_RS00275 (SPy0033) purE 48042..48533 (+) 492 WP_002987716.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  SPY_RS00280 (SPy0034) purK 48520..49593 (+) 1074 WP_015055885.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  SPY_RS00285 (SPy0035) - 49620..51263 (+) 1644 WP_010921779.1 AIPR family protein -
  SPY_RS00290 (SPy0036) purB 51281..52573 (+) 1293 WP_010921780.1 adenylosuccinate lyase -
  SPY_RS00295 (SPy0037) comR 52705..53616 (+) 912 WP_002986681.1 transcriptional regulator Rgg4/ComR Regulator
  SPY_RS00300 (SPy0038) ruvB 53842..54840 (+) 999 WP_002986679.1 Holliday junction branch migration DNA helicase RuvB -
  SPY_RS00305 (SPy0039) - 54978..55415 (+) 438 WP_002994668.1 low molecular weight protein-tyrosine-phosphatase -
  SPY_RS00310 (SPy0040) - 55438..55839 (+) 402 WP_010921781.1 MORN repeat-containing protein -
  SPY_RS00315 (SPy0041) - 55836..57611 (+) 1776 WP_010921782.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35757.27 Da        Isoelectric Point: 4.4858

>NTDB_id=20850 SPY_RS00295 WP_002986681.1 52705..53616(+) (comR) [Streptococcus pyogenes M1 GAS]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 912 bp        

>NTDB_id=20850 SPY_RS00295 WP_002986681.1 52705..53616(+) (comR) [Streptococcus pyogenes M1 GAS]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(12-64)

ComR tetratricopeptide (ComR_TPR)

(73-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

100

100

1
  comR Streptococcus pyogenes MGAS315

58.472

99.34

0.581
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

51.37

96.37

0.495
  comR Streptococcus mutans UA159

46.358

99.67

0.462

Multiple sequence alignment