Detailed information NTG0208238

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: BSL41_RS08675
• Genome accession: NZ_CP018347
• Coordinates: 1579787..1582027 (-)
• Length: 746 a.a.
• NCBI ID: WP_000942392.1
• Uniprot ID: A0A6I3VL05
• Organism: Streptococcus pneumoniae strain SWU02
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1574787..1587027

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BSL41_RS08640	-	1575697..1576077 (-)	381	WP_000157154.1	VOC family protein	-
BSL41_RS08645	rplT	1576135..1576494 (-)	360	WP_000124836.1	50S ribosomal protein L20	-
BSL41_RS08650	rpmI	1576546..1576746 (-)	201	WP_001125943.1	50S ribosomal protein L35	-
BSL41_RS08655	infC	1576779..1577309 (-)	531	WP_194284569.1	translation initiation factor IF-3	-
BSL41_RS08660	-	1577616..1578797 (-)	1182	WP_000655951.1	membrane protein	-
BSL41_RS08665	-	1578801..1579388 (-)	588	WP_000939884.1	ATP-binding cassette domain-containing protein	-
BSL41_RS08670	-	1579421..1579645 (-)	225	WP_000583432.1	hypothetical protein	-
BSL41_RS08675	comEC/celB	1579787..1582027 (-)	2241	WP_000942392.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
BSL41_RS08680	comEA/celA/cilE	1582011..1582661 (-)	651	WP_000387328.1	ComEA family DNA-binding protein	Machinery gene
BSL41_RS08685	-	1582729..1583298 (-)	570	WP_000443775.1	GNAT family N-acetyltransferase	-
BSL41_RS12440	ald	1583475..1584586 (+)	1112	Protein_1563	alanine dehydrogenase	-
BSL41_RS08705	-	1584887..1585213 (-)	327	Protein_1564	TfoX/Sxy family protein	-
BSL41_RS08710	-	1585216..1585716 (-)	501	WP_000566986.1	GNAT family N-acetyltransferase	-
BSL41_RS08720	-	1585909..1586877 (-)	969	WP_000658198.1	PhoH family protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84589.24 Da
• Isoelectric Point: 9.8000

>NTDB_id=208238 BSL41_RS08675 WP_000942392.1 1579787..1582027(-) (comEC/celB) [Streptococcus pneumoniae strain SWU02]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCLFIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKKIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGYLNTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLIGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVASESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVARRPLVFGQPNAWLLILLLISLALVYDLRKNIKGLTVLSLLITGLFFLTK
YPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIEKWQEKMTTSNAQRSLIPYLKSRGVAKIDQLILTNTDK
EHVGDLLEVTKAFHVGEILVSKGSLKQKQFVVELQATQTKVRSMTVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGNKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGWNSWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=208238 BSL41_RS08675 WP_000942392.1 1579787..1582027(-) (comEC/celB) [Streptococcus pneumoniae strain SWU02]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTATTACTTTGGCTTTATTACGCTATTTT
CTCAGCATCTTATCTTGCTTTGTTGGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTATCCAATTTCCGTGGAAATCTGCTG
GTAAAGTTCTAATAATTTGCGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTACCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAAAAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGATATCTGAACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGCATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAATTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTGCTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTAGAGGGCATTATTCGCTTGGT
CTCGCAGGTGGCAAGGAGACCGCTTGTCTTTGGTCAACCCAACGCATGGCTTTTAATCTTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAGGATTAACAGTATTGAGTTTATTGATTACAGGTCTCTTTTTCCTTACCAAG
TATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CACAGAGAAGCTTGATACCCTATCTTAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTGATTTTGACAAATACGGACAAG
GAACATGTCGGAGATTTGTTAGAGGTGACCAAGGCTTTCCATGTAGGGGAGATTTTAGTATCAAAAGGCAGTTTGAAGCA
GAAGCAATTTGTGGTAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGACAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCCCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCAATAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTACCGAACTGACCAGCAAGGAGCTATACGGTTTAAAGGTTGGAATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-693)

• Domain of unknown function (DUF4131) (DUF4131) (30-177)

• Competence protein (Competence) (216-458)

3D structure

• AlphaFold DB: A0A6I3VL05

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus pneumoniae TIGR4	97.721	100	0.977
comEC/celB	Streptococcus pneumoniae Rx1	96.649	100	0.966
comEC/celB	Streptococcus pneumoniae D39	96.649	100	0.966
comEC/celB	Streptococcus pneumoniae R6	96.649	100	0.966
comEC/celB	Streptococcus mitis SK321	92.493	100	0.925
comEC/celB	Streptococcus mitis NCTC 12261	92.349	99.866	0.922
comEC	Lactococcus lactis subsp. cremoris KW2	44.534	99.33	0.442