Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   SPG_1704 Genome accession   CP001015
Coordinates   1638319..1638978 (+) Length   219 a.a.
NCBI ID   ACF56808.1    Uniprot ID   -
Organism   Streptococcus pneumoniae G54     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1625050..1658811 1638319..1638978 within 0


Gene organization within MGE regions


Location: 1625050..1658811
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPG_1685 - 1625050..1626045 (-) 996 ACF56041.1 sucrose operon repressor -
  SPG_1686 mgrA 1626407..1627888 (-) 1482 ACF56648.1 Mga-like repressor A MgrA -
  SPG_1687 - 1628331..1628495 (+) 165 ACF55937.1 conserved hypothetical protein -
  SPG_1688 - 1628579..1629145 (+) 567 ACF56542.1 conserved hypothetical protein -
  SPG_1689 - 1629157..1629327 (+) 171 ACF56428.1 conserved hypothetical protein -
  SPG_1690 - 1629366..1629974 (+) 609 ACF54873.1 conserved hypothetical protein -
  SPG_1691 - 1630005..1630208 (+) 204 ACF55751.1 conserved hypothetical protein -
  SPG_1692 - 1631022..1631141 (-) 120 ACF56216.1 hypothetical protein -
  SPG_1693 - 1631359..1632129 (-) 771 ACF56129.1 hypothetical protein -
  SPG_1694 - 1632144..1632770 (-) 627 ACF55001.1 conserved domain protein -
  SPG_1695 - 1632676..1633026 (-) 351 ACF55449.1 PTS system, IIC component -
  SPG_1696 - 1632980..1633279 (-) 300 ACF55915.1 PTS system, IIC component -
  SPG_1697 - 1633289..1633606 (-) 318 ACF56379.1 PTS system, IIA component -
  SPG_1698 - 1633623..1633940 (-) 318 ACF56806.1 PTS system, IIB component -
  SPG_1699 - 1633955..1634557 (-) 603 ACF54790.1 conserved hypothetical protein -
  SPG_1700 - 1634544..1634852 (-) 309 ACF56606.1 conserved hypothetical protein -
  SPG_1701 - 1634855..1636117 (-) 1263 ACF56020.1 PTS system, IIC component -
  SPG_1702 - 1636397..1637575 (+) 1179 ACF55661.1 Transcriptional regulator/sugar kinase -
  SPG_1703 - 1637803..1638249 (-) 447 ACF55255.1 acetyltransferase, GNAT family protein -
  SPG_1704 cclA/cilC 1638319..1638978 (+) 660 ACF56808.1 type 4 prepilin peptidase, putative Machinery gene
  SPG_1705 - 1639030..1640181 (-) 1152 ACF55362.1 transcriptional regulator -
  SPG_1706 - 1640196..1640927 (-) 732 ACF54807.1 conserved hypothetical protein -
  SPG_1707 trpA 1641229..1642005 (-) 777 ACF55433.1 tryptophan synthase alpha chain -
  SPG_1708 trpB 1641998..1643221 (-) 1224 ACF54983.1 tryptophan synthase beta chain -
  SPG_1709 trpF 1643199..1643798 (-) 600 ACF56513.1 N-(5'-phosphoribosyl)anthranilate isomerase -
  SPG_1710 trpC 1643785..1644552 (-) 768 ACF55982.1 indole-3-glycerol phosphate synthase -
  SPG_1711 trpD 1644549..1645553 (-) 1005 ACF55364.1 anthranilate phosphoribosyltransferase -
  SPG_1712 trpG 1645564..1646130 (-) 567 ACF55291.1 anthranilate synthase component II -
  SPG_1713 trpE 1646127..1647488 (-) 1362 ACF56463.1 anthranilate synthase component I -
  SPG_1714 - 1648809..1649810 (-) 1002 ACF55581.1 transcriptional regulator, LacI family -
  SPG_1715 - 1650382..1651092 (-) 711 ACF55495.1 conserved hypothetical protein -
  SPG_1716 - 1651095..1652786 (-) 1692 ACF55660.1 ABC transporter, permease protein -
  SPG_1717 - 1652798..1653808 (-) 1011 ACF55039.1 ABC transporter, ATP-binding protein -
  SPG_1718 - 1653912..1654979 (-) 1068 ACF56419.1 ABC transporter, substrate-binding protein -
  SPG_1719 - 1655004..1655663 (-) 660 ACF56003.1 conserved hypothetical protein -
  SPG_1720 - 1656685..1658811 (-) 2127 ACF55753.1 hypothetical protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24911.19 Da        Isoelectric Point: 8.1491

>NTDB_id=20211 SPG_1704 ACF56808.1 1638319..1638978(+) (cclA/cilC) [Streptococcus pneumoniae G54]
MIDFYFFLVGSILXSFLGLVIDRFPEQSIISSAXXCDSCQTRLRPLXLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSKVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=20211 SPG_1704 ACF56808.1 1638319..1638978(+) (cclA/cilC) [Streptococcus pneumoniae G54]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTANCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCANTCNCTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTANATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTAAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae Rx1

97.717

100

0.977
  cclA/cilC Streptococcus pneumoniae D39

97.717

100

0.977
  cclA/cilC Streptococcus pneumoniae R6

97.717

100

0.977
  cclA/cilC Streptococcus pneumoniae TIGR4

92.694

100

0.927
  cclA/cilC Streptococcus mitis SK321

90.411

100

0.904
  cclA/cilC Streptococcus mitis NCTC 12261

85.388

100

0.854

Multiple sequence alignment