Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/comE1   Type   Machinery gene
Locus tag   BG585_RS12360 Genome accession   NZ_CP017551
Coordinates   2387056..2387394 (+) Length   112 a.a.
NCBI ID   WP_006251644.1    Uniprot ID   A0A248ZWT2
Organism   Mannheimia haemolytica strain 1287     
Function   dsDNA binding (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 2365199..2396608 2387056..2387394 within 0


Gene organization within MGE regions


Location: 2365199..2396608
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BG585_RS12235 (BG585_12010) - 2365199..2365501 (+) 303 WP_006250278.1 BrnA antitoxin family protein -
  BG585_RS12240 (BG585_12015) - 2365519..2365812 (-) 294 WP_006253765.1 DUF3144 domain-containing protein -
  BG585_RS12250 (BG585_12020) rpoH 2365978..2366937 (-) 960 WP_006250280.1 RNA polymerase sigma factor RpoH -
  BG585_RS12260 (BG585_12030) - 2367744..2368970 (+) 1227 WP_006250282.1 integrase arm-type DNA-binding domain-containing protein -
  BG585_RS14930 (BG585_12035) - 2369245..2369463 (+) 219 WP_006253767.1 type II toxin-antitoxin system RelE/ParE family toxin -
  BG585_RS12270 (BG585_12040) - 2369576..2369899 (+) 324 WP_006250284.1 addiction module antidote protein -
  BG585_RS12275 (BG585_12045) - 2370294..2370980 (+) 687 WP_006250286.1 hypothetical protein -
  BG585_RS14810 - 2370990..2371112 (+) 123 WP_006250287.1 hypothetical protein -
  BG585_RS14420 - 2371141..2371293 (+) 153 WP_015484065.1 hypothetical protein -
  BG585_RS12280 (BG585_12050) - 2371300..2371725 (+) 426 WP_006250289.1 hypothetical protein -
  BG585_RS12285 (BG585_12055) - 2371722..2372414 (+) 693 WP_006250290.1 terminase small subunit -
  BG585_RS12290 (BG585_12060) - 2372954..2373565 (-) 612 WP_015484064.1 autotransporter domain-containing protein -
  BG585_RS12295 (BG585_12065) cysE 2373614..2374429 (-) 816 WP_006250292.1 serine O-acetyltransferase -
  BG585_RS12300 (BG585_12070) gpsA 2374445..2375455 (-) 1011 WP_006250293.1 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase -
  BG585_RS12305 (BG585_12075) secB 2375562..2376062 (-) 501 WP_006250294.1 protein-export chaperone SecB -
  BG585_RS12310 (BG585_12080) - 2376083..2376535 (-) 453 WP_006250295.1 rhodanese-like domain-containing protein -
  BG585_RS12315 (BG585_12085) tig 2376651..2377949 (-) 1299 WP_006250884.1 trigger factor -
  BG585_RS12320 (BG585_12090) tuf 2378246..2379430 (-) 1185 WP_006249832.1 elongation factor Tu -
  BG585_RS12325 (BG585_12095) fusA 2379490..2381592 (-) 2103 WP_006249833.1 elongation factor G -
  BG585_RS12330 (BG585_12100) rpsG 2381694..2382164 (-) 471 WP_006249834.1 30S ribosomal protein S7 -
  BG585_RS12335 (BG585_12105) rpsL 2382295..2382669 (-) 375 WP_005543325.1 30S ribosomal protein S12 -
  BG585_RS12340 (BG585_12110) rfaC 2382790..2383749 (-) 960 WP_006250332.1 lipopolysaccharide heptosyltransferase RfaC -
  BG585_RS12345 (BG585_12115) waaF 2383816..2384853 (-) 1038 WP_006250331.1 lipopolysaccharide heptosyltransferase II -
  BG585_RS12350 (BG585_12120) - 2384964..2385380 (-) 417 WP_006250330.1 MliC family protein -
  BG585_RS12355 (BG585_12125) - 2385444..2386763 (-) 1320 WP_006253337.1 LysM-like peptidoglycan-binding domain-containing protein -
  BG585_RS12360 (BG585_12130) comEA/comE1 2387056..2387394 (+) 339 WP_006251644.1 ComEA family DNA-binding protein Machinery gene
  BG585_RS12365 (BG585_12135) asd 2387559..2388452 (+) 894 WP_006250004.1 archaetidylserine decarboxylase -
  BG585_RS12370 (BG585_12140) hsdR 2388524..2390875 (+) 2352 WP_006250003.1 EcoAI/FtnUII family type I restriction enzme subunit R -
  BG585_RS12375 (BG585_12145) - 2390923..2392392 (+) 1470 WP_006250002.1 HsdM family class I SAM-dependent methyltransferase -
  BG585_RS12380 (BG585_12150) - 2392405..2394066 (+) 1662 WP_006253335.1 RNA-binding domain-containing protein -
  BG585_RS14815 - 2394114..2394248 (+) 135 WP_006253334.1 Fic family protein -
  BG585_RS12385 (BG585_12155) - 2394272..2395759 (+) 1488 WP_006250001.1 restriction endonuclease subunit S -
  BG585_RS12390 (BG585_12160) - 2395805..2396608 (-) 804 WP_006250000.1 tyrosine-type recombinase/integrase -

Sequence

Protein


Download         Length: 112 a.a.        Molecular weight: 12111.91 Da        Isoelectric Point: 10.0993

>NTDB_id=200285 BG585_RS12360 WP_006251644.1 2387056..2387394(+) (comEA/comE1) [Mannheimia haemolytica strain 1287]
MKKIKQLGLTFLFGLNAMAFAQTPPTTMPVEQNAVTQPVQQTQITNANAVNINTASAAELQDKLVGIGQKKAQAIVDYRT
KNGNFKNIEQLAEVSGIGQATVEKNRANIILE

Nucleotide


Download         Length: 339 bp        

>NTDB_id=200285 BG585_RS12360 WP_006251644.1 2387056..2387394(+) (comEA/comE1) [Mannheimia haemolytica strain 1287]
ATGAAGAAAATCAAACAACTTGGTCTAACATTCTTGTTTGGCTTAAATGCAATGGCTTTTGCCCAAACACCGCCAACTAC
AATGCCTGTTGAACAAAATGCAGTCACTCAACCCGTACAGCAAACACAAATCACCAACGCTAATGCGGTAAATATCAATA
CTGCTAGTGCTGCTGAATTGCAAGACAAGCTAGTGGGAATTGGGCAGAAAAAAGCTCAAGCGATTGTCGATTACCGTACT
AAAAACGGCAATTTTAAAAACATTGAGCAACTTGCTGAAGTCTCCGGAATTGGGCAAGCAACGGTAGAAAAAAATCGAGC
CAATATTATTTTAGAATAA

Domains

Predicted by InterproScan.

Helix-hairpin-helix motif (HHH_3)

(46-109)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A248ZWT2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/comE1 Glaesserella parasuis strain SC1401

59.292

100

0.598
  comE1/comEA Haemophilus influenzae Rd KW20

52.747

81.25

0.429
  comEA Vibrio cholerae C6706

54.651

76.786

0.42
  comEA Vibrio cholerae strain A1552

54.651

76.786

0.42

Multiple sequence alignment