Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/comE1   Type   Machinery gene
Locus tag   BG610_RS11990 Genome accession   NZ_CP017519
Coordinates   2327099..2327437 (+) Length   112 a.a.
NCBI ID   WP_006251644.1    Uniprot ID   A0A248ZWT2
Organism   Mannheimia haemolytica strain 22549     
Function   dsDNA binding (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 2305242..2336651 2327099..2327437 within 0


Gene organization within MGE regions


Location: 2305242..2336651
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BG610_RS11865 (BG610_11650) - 2305242..2305544 (+) 303 WP_006250278.1 BrnA antitoxin family protein -
  BG610_RS11870 (BG610_11655) - 2305562..2305855 (-) 294 WP_006253765.1 DUF3144 domain-containing protein -
  BG610_RS11880 (BG610_11660) rpoH 2306021..2306980 (-) 960 WP_006250280.1 RNA polymerase sigma factor RpoH -
  BG610_RS11890 (BG610_11670) - 2307787..2309013 (+) 1227 WP_006250282.1 integrase arm-type DNA-binding domain-containing protein -
  BG610_RS14550 (BG610_11675) - 2309288..2309506 (+) 219 WP_006253767.1 type II toxin-antitoxin system RelE/ParE family toxin -
  BG610_RS11900 (BG610_11680) - 2309619..2309942 (+) 324 WP_006250284.1 addiction module antidote protein -
  BG610_RS11905 (BG610_11685) - 2310337..2311023 (+) 687 WP_006250286.1 hypothetical protein -
  BG610_RS14445 - 2311033..2311155 (+) 123 WP_006250287.1 hypothetical protein -
  BG610_RS14075 - 2311184..2311336 (+) 153 WP_015484065.1 hypothetical protein -
  BG610_RS11910 (BG610_11690) - 2311343..2311768 (+) 426 WP_006250289.1 hypothetical protein -
  BG610_RS11915 (BG610_11695) - 2311765..2312457 (+) 693 WP_006250290.1 terminase small subunit -
  BG610_RS11920 (BG610_11700) - 2312997..2313608 (-) 612 WP_015484064.1 autotransporter domain-containing protein -
  BG610_RS11925 (BG610_11705) cysE 2313657..2314472 (-) 816 WP_006250292.1 serine O-acetyltransferase -
  BG610_RS11930 (BG610_11710) gpsA 2314488..2315498 (-) 1011 WP_006250293.1 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase -
  BG610_RS11935 (BG610_11715) secB 2315605..2316105 (-) 501 WP_006250294.1 protein-export chaperone SecB -
  BG610_RS11940 (BG610_11720) - 2316126..2316578 (-) 453 WP_006250295.1 rhodanese-like domain-containing protein -
  BG610_RS11945 (BG610_11725) tig 2316694..2317992 (-) 1299 WP_006250884.1 trigger factor -
  BG610_RS11950 (BG610_11730) tuf 2318289..2319473 (-) 1185 WP_006249832.1 elongation factor Tu -
  BG610_RS11955 (BG610_11735) fusA 2319533..2321635 (-) 2103 WP_006249833.1 elongation factor G -
  BG610_RS11960 (BG610_11740) rpsG 2321737..2322207 (-) 471 WP_006249834.1 30S ribosomal protein S7 -
  BG610_RS11965 (BG610_11745) rpsL 2322338..2322712 (-) 375 WP_005543325.1 30S ribosomal protein S12 -
  BG610_RS11970 (BG610_11750) rfaC 2322833..2323792 (-) 960 WP_006250332.1 lipopolysaccharide heptosyltransferase RfaC -
  BG610_RS11975 (BG610_11755) waaF 2323859..2324896 (-) 1038 WP_006250331.1 lipopolysaccharide heptosyltransferase II -
  BG610_RS11980 (BG610_11760) - 2325007..2325423 (-) 417 WP_006250330.1 MliC family protein -
  BG610_RS11985 (BG610_11765) - 2325487..2326806 (-) 1320 WP_006253337.1 LysM-like peptidoglycan-binding domain-containing protein -
  BG610_RS11990 (BG610_11770) comEA/comE1 2327099..2327437 (+) 339 WP_006251644.1 ComEA family DNA-binding protein Machinery gene
  BG610_RS11995 (BG610_11775) asd 2327602..2328495 (+) 894 WP_006250004.1 archaetidylserine decarboxylase -
  BG610_RS12000 (BG610_11780) hsdR 2328567..2330918 (+) 2352 WP_006250003.1 EcoAI/FtnUII family type I restriction enzme subunit R -
  BG610_RS12005 (BG610_11785) - 2330966..2332435 (+) 1470 WP_006250002.1 HsdM family class I SAM-dependent methyltransferase -
  BG610_RS12010 (BG610_11790) - 2332448..2334109 (+) 1662 WP_006253335.1 RNA-binding domain-containing protein -
  BG610_RS14080 - 2334139..2334291 (+) 153 WP_015586944.1 Fic family protein -
  BG610_RS12015 (BG610_11795) - 2334315..2335802 (+) 1488 WP_006250001.1 restriction endonuclease subunit S -
  BG610_RS12020 (BG610_11800) - 2335848..2336651 (-) 804 WP_006250000.1 tyrosine-type recombinase/integrase -

Sequence

Protein


Download         Length: 112 a.a.        Molecular weight: 12111.91 Da        Isoelectric Point: 10.0993

>NTDB_id=199562 BG610_RS11990 WP_006251644.1 2327099..2327437(+) (comEA/comE1) [Mannheimia haemolytica strain 22549]
MKKIKQLGLTFLFGLNAMAFAQTPPTTMPVEQNAVTQPVQQTQITNANAVNINTASAAELQDKLVGIGQKKAQAIVDYRT
KNGNFKNIEQLAEVSGIGQATVEKNRANIILE

Nucleotide


Download         Length: 339 bp        

>NTDB_id=199562 BG610_RS11990 WP_006251644.1 2327099..2327437(+) (comEA/comE1) [Mannheimia haemolytica strain 22549]
ATGAAGAAAATCAAACAACTTGGTCTAACATTCTTGTTTGGCTTAAATGCAATGGCTTTTGCCCAAACACCGCCAACTAC
AATGCCTGTTGAACAAAATGCAGTCACTCAACCCGTACAGCAAACACAAATCACCAACGCTAATGCGGTAAATATCAATA
CTGCTAGTGCTGCTGAATTGCAAGACAAGCTAGTGGGAATTGGGCAGAAAAAAGCTCAAGCGATTGTCGATTACCGTACT
AAAAACGGCAATTTTAAAAACATTGAGCAACTTGCTGAAGTCTCCGGAATTGGGCAAGCAACGGTAGAAAAAAATCGAGC
CAATATTATTTTAGAATAA

Domains

Predicted by InterproScan.

Helix-hairpin-helix motif (HHH_3)

(46-109)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A248ZWT2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/comE1 Glaesserella parasuis strain SC1401

59.292

100

0.598
  comE1/comEA Haemophilus influenzae Rd KW20

52.747

81.25

0.429
  comEA Vibrio cholerae C6706

54.651

76.786

0.42
  comEA Vibrio cholerae strain A1552

54.651

76.786

0.42

Multiple sequence alignment