Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicK   Type   Regulator
Locus tag   NX99_RS02365 Genome accession   NZ_CP015282
Coordinates   608993..610336 (-) Length   447 a.a.
NCBI ID   WP_038675887.1    Uniprot ID   A0A448AAV4
Organism   Streptococcus salivarius strain ATCC 27945     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 603993..615336
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NX99_RS02335 (NX99_02310) - 604170..604556 (-) 387 WP_048790817.1 DUF1934 domain-containing protein -
  NX99_RS02340 (NX99_02315) - 604639..605505 (-) 867 WP_084914609.1 GNAT family N-acetyltransferase -
  NX99_RS02345 (NX99_02320) yidA 605683..606492 (+) 810 WP_002890845.1 sugar-phosphatase -
  NX99_RS02350 (NX99_02325) - 606494..607708 (+) 1215 WP_084914610.1 aminoacyltransferase -
  NX99_RS02355 (NX99_02330) - 607760..608119 (-) 360 WP_037611660.1 YbaN family protein -
  NX99_RS02360 (NX99_02335) vicX 608178..608987 (-) 810 WP_126405093.1 MBL fold metallo-hydrolase Regulator
  NX99_RS02365 (NX99_02340) vicK 608993..610336 (-) 1344 WP_038675887.1 cell wall metabolism sensor histidine kinase VicK Regulator
  NX99_RS02370 (NX99_02345) vicR 610329..611036 (-) 708 WP_002884978.1 response regulator YycF Regulator
  NX99_RS02375 (NX99_02350) - 611336..612103 (+) 768 WP_038675884.1 amino acid ABC transporter ATP-binding protein -
  NX99_RS02380 (NX99_02355) - 612113..612946 (+) 834 WP_037611665.1 transporter substrate-binding domain-containing protein -
  NX99_RS02385 (NX99_02360) - 612964..613662 (+) 699 WP_002886251.1 amino acid ABC transporter permease -
  NX99_RS02390 (NX99_02365) - 613674..614324 (+) 651 WP_037601175.1 amino acid ABC transporter permease -
  NX99_RS02395 (NX99_02370) - 614510..615277 (+) 768 WP_060775856.1 amino acid ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 447 a.a.        Molecular weight: 51002.17 Da        Isoelectric Point: 4.9199

>NTDB_id=178200 NX99_RS02365 WP_038675887.1 608993..610336(-) (vicK) [Streptococcus salivarius strain ATCC 27945]
MTSIGLNITSFELALLFTLLFVAFYFIFLAYRDYRQVKNIRKLTKRVKSLMAGNYNEELRLKGDPELLELADSLNDLSDV
FRLTHENLAQEKNRLSSVLSYMSDGVIATNRRGQITMINSTAQRLLNLDFETATQMSILDLLDGENPYTYSELLSKTPEI
HLSRRDANDEFVTLRVNFALIRKESGFISGLVAVLHDATEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDDGALNE
DIAPNFIKVSLDETNRMMRMISDLLALSRIDNKSTQLDVEMTNFTAFMTYILNRFDQIKSQESNTGKTYEIIRDYPVNSI
WVEIDTDKMTQVVDNILNNAIKYSPDGGEITVSMKTTDSQLIVSISDQGLGIPKKDLPLIFDRFYRVDKARSRAQGGTGL
GLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAMMVDEWEME

Nucleotide


Download         Length: 1344 bp        

>NTDB_id=178200 NX99_RS02365 WP_038675887.1 608993..610336(-) (vicK) [Streptococcus salivarius strain ATCC 27945]
ATGACTAGTATTGGCTTAAACATCACAAGCTTTGAACTAGCCTTACTCTTTACGCTCCTTTTTGTGGCTTTCTACTTTAT
TTTTCTTGCTTATCGTGATTATCGACAAGTCAAAAATATTCGAAAGTTGACCAAGAGGGTCAAGTCCTTAATGGCAGGTA
ACTATAATGAGGAGTTACGTTTAAAGGGTGATCCAGAGCTTTTAGAGCTAGCTGATAGCTTAAATGATTTATCGGACGTC
TTTCGTTTGACACATGAAAATCTAGCCCAGGAAAAAAACCGCTTATCATCAGTCCTCTCTTACATGAGTGATGGAGTCAT
TGCGACAAATCGTCGTGGTCAAATTACCATGATTAATAGCACAGCTCAGCGTTTGTTGAATCTAGATTTTGAGACAGCGA
CACAGATGTCCATTTTAGACTTATTAGATGGTGAAAATCCCTACACCTATAGTGAATTGCTGTCTAAGACTCCTGAAATT
CATTTGTCTCGTCGAGATGCCAACGATGAATTTGTGACCTTACGCGTTAACTTTGCTCTTATTCGTAAAGAGTCTGGATT
CATTTCGGGTCTGGTTGCCGTTCTTCATGATGCTACTGAGCAGGAAAAAGAAGAGCGTGAACGTCGTCTATTTGTTTCAA
ACGTTAGTCACGAGTTGCGTACACCTCTGACTTCTGTAAAATCTTATCTAGAGGCACTTGATGATGGAGCTCTCAACGAA
GATATCGCCCCTAACTTTATCAAAGTTTCGCTAGATGAGACCAATCGTATGATGCGAATGATTTCTGACCTCTTGGCACT
TTCTCGTATTGACAATAAGAGCACTCAACTTGATGTTGAAATGACTAATTTCACGGCCTTCATGACCTATATCTTGAATC
GTTTTGATCAAATCAAAAGTCAAGAAAGCAATACTGGTAAGACGTACGAAATTATTCGAGATTACCCTGTAAATTCTATT
TGGGTGGAGATTGATACGGATAAGATGACTCAGGTCGTGGATAATATTCTTAACAATGCCATCAAGTATTCTCCTGATGG
TGGTGAGATTACAGTGTCCATGAAGACAACTGATTCACAGTTGATTGTTTCTATTTCTGACCAAGGTTTAGGTATCCCTA
AGAAAGATTTACCTTTGATTTTCGACCGTTTTTACCGTGTTGATAAGGCCAGAAGTCGTGCCCAGGGTGGAACGGGTCTA
GGCTTGTCCATTGCCAAAGAGATTATTAAACAACATAAGGGCTTCATTTGGGCTAAGAGTGAGTATGGTAAGGGTTCAAC
ATTTACAATTGTGCTTCCATATGACAAGGATGCCATGATGGTTGATGAATGGGAGATGGAGTAG

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(208-272)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(325-435)

PAS fold (PAS)

(94-197)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A448AAV4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicK Streptococcus mutans UA159

73.671

92.617

0.682
  micB Streptococcus pneumoniae Cp1015

67.436

96.868

0.653

Multiple sequence alignment