Detailed information NTG0172403

Bioinformatically predicted

Overview

• Name: crp
• Type: Regulator
• Locus tag: A2U21_RS09750
• Genome accession: NZ_CP018034
• Coordinates: 1906579..1907253 (+)
• Length: 224 a.a.
• NCBI ID: WP_010787261.1
• Uniprot ID: B8F851
• Organism: Glaesserella parasuis str. Nagasaki
• Function: promote expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1901579..1912253

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A2U21_RS09710 (A2U21_09410)	rpmG	1902217..1902387 (-)	171	WP_005624479.1	50S ribosomal protein L33	-
A2U21_RS09715 (A2U21_09415)	rpmB	1902399..1902635 (-)	237	WP_006251446.1	50S ribosomal protein L28	-
A2U21_RS09720 (A2U21_09420)	radC	1902761..1903477 (-)	717	WP_005713175.1	RadC family protein	Machinery gene
A2U21_RS09725 (A2U21_09425)	coaBC	1903647..1904849 (+)	1203	WP_021110350.1	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC	-
A2U21_RS09730 (A2U21_09430)	-	1904859..1905185 (+)	327	WP_005713172.1	hypothetical protein	-
A2U21_RS09735 (A2U21_09435)	dut	1905211..1905666 (+)	456	WP_021110349.1	dUTP diphosphatase	-
A2U21_RS09740 (A2U21_09440)	slmA	1905675..1906280 (+)	606	WP_005713169.1	nucleoid occlusion factor SlmA	-
A2U21_RS09745 (A2U21_09445)	-	1906288..1906512 (+)	225	WP_005713165.1	YheU family protein	-
A2U21_RS09750 (A2U21_09450)	crp	1906579..1907253 (+)	675	WP_010787261.1	cAMP-activated global transcriptional regulator CRP	Regulator
A2U21_RS09755 (A2U21_09455)	-	1907508..1907759 (+)	252	WP_223300025.1	hypothetical protein	-
A2U21_RS12265 (A2U21_09460)	-	1907798..1907944 (+)	147	WP_021110348.1	hypothetical protein	-
A2U21_RS09765 (A2U21_09465)	pyrD	1908152..1909159 (-)	1008	WP_021110347.1	quinone-dependent dihydroorotate dehydrogenase	-
A2U21_RS09775 (A2U21_09475)	-	1909409..1910359 (-)	951	WP_005713153.1	ribose-phosphate pyrophosphokinase	-
A2U21_RS09780 (A2U21_09480)	ispE	1910387..1911232 (-)	846	WP_021110346.1	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	-
A2U21_RS09785 (A2U21_09485)	lolB	1911234..1911866 (-)	633	WP_021110345.1	lipoprotein insertase outer membrane protein LolB	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25208.17 Da
• Isoelectric Point: 6.9079

>NTDB_id=172403 A2U21_RS09750 WP_010787261.1 1906579..1907253(+) (crp) [Glaesserella parasuis str. Nagasaki]
MQDVSISTAQLEDVSPLPSIHDPSVEWFLTHCHIHRYPAKYTLIHAGEDAESLFYIVSGAVSVFIKDEEGKEMLLTNLGQ
GEFVGEISLFEEKAQPRTAWVRTKGNCEIAEISYKKFKQLVHLNPDILMYLSAQMARRLRMTSRQVSNLAFLDVTGRIAQ
TLMNLAKMPDAMTHPQGMQIKITRQEIGQMVGCSRETVGRILKMLEDEGLISAHGKTIVVYGTR

Nucleotide

• Length: 675 bp

>NTDB_id=172403 A2U21_RS09750 WP_010787261.1 1906579..1907253(+) (crp) [Glaesserella parasuis str. Nagasaki]
ATGCAAGATGTTTCAATCTCAACCGCACAGCTTGAAGATGTCAGCCCATTACCATCCATTCACGATCCTTCGGTGGAATG
GTTTTTAACTCACTGTCATATTCATCGTTATCCAGCAAAATATACTTTAATTCACGCAGGTGAAGATGCTGAATCACTGT
TTTATATTGTCAGCGGAGCTGTGTCTGTCTTTATCAAGGATGAAGAAGGCAAGGAGATGTTATTAACCAATTTAGGACAA
GGCGAATTTGTCGGTGAAATCAGCCTTTTTGAAGAAAAGGCTCAGCCTCGCACTGCTTGGGTAAGAACTAAAGGCAACTG
TGAAATTGCTGAAATTTCTTATAAAAAATTCAAGCAATTAGTTCATCTAAATCCTGATATCTTAATGTATCTCTCAGCTC
AGATGGCTCGCCGTTTACGAATGACATCAAGACAGGTTAGTAACCTTGCATTCCTTGATGTAACAGGCCGTATTGCTCAA
ACATTGATGAATTTAGCTAAAATGCCTGATGCGATGACTCACCCTCAGGGTATGCAGATTAAAATTACTCGCCAAGAAAT
TGGTCAAATGGTTGGTTGCTCACGAGAAACTGTAGGCCGTATTTTGAAAATGCTTGAGGATGAAGGGTTAATTTCTGCAC
ATGGTAAAACTATCGTTGTGTATGGGACAAGATAA

Domains

Predicted by InterProScan.

• Cyclic nucleotide-binding domain (cNMP_binding) (35-121)

• Crp-like helix-turn-helix domain (HTH_Crp_2) (156-220)

3D structure

• AlphaFold DB: B8F851

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
crp	Vibrio cholerae strain A1552	75.862	90.625	0.687
crp	Haemophilus influenzae Rd KW20	73.399	90.625	0.665
crp	Acinetobacter baumannii D1279779	48.5	89.286	0.433