Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   AXE83_RS06995 Genome accession   NZ_CP014264
Coordinates   1482913..1484247 (-) Length   444 a.a.
NCBI ID   WP_060955914.1    Uniprot ID   A0A109W8Z1
Organism   Streptococcus sp. oral taxon 431 strain F0610 (5-114)     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1477913..1489247
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AXE83_RS06970 (AXE83_06970) rpiA 1478460..1479143 (-) 684 WP_060955909.1 ribose-5-phosphate isomerase RpiA -
  AXE83_RS06975 (AXE83_06975) - 1479249..1480178 (-) 930 WP_060955910.1 peptidase U32 family protein -
  AXE83_RS06980 (AXE83_06980) - 1480417..1481097 (-) 681 WP_060955911.1 ABC transporter ATP-binding protein -
  AXE83_RS06985 (AXE83_06985) - 1481111..1482166 (-) 1056 WP_060955912.1 ABC transporter permease -
  AXE83_RS06990 (AXE83_06990) - 1482528..1482803 (+) 276 WP_060955913.1 DUF3270 family protein -
  AXE83_RS06995 (AXE83_06995) ciaH 1482913..1484247 (-) 1335 WP_060955914.1 HAMP domain-containing sensor histidine kinase Regulator
  AXE83_RS07000 (AXE83_07000) ciaR 1484240..1484911 (-) 672 WP_000590624.1 response regulator transcription factor Regulator
  AXE83_RS07005 (AXE83_07005) - 1485027..1487573 (-) 2547 WP_060955915.1 M1 family metallopeptidase -
  AXE83_RS07010 (AXE83_07010) - 1487696..1488136 (-) 441 WP_060955916.1 ASCH domain-containing protein -
  AXE83_RS07015 (AXE83_07015) - 1488133..1488981 (-) 849 WP_060955917.1 putative PEP-binding protein -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50394.90 Da        Isoelectric Point: 9.3860

>NTDB_id=170006 AXE83_RS06995 WP_060955914.1 1482913..1484247(-) (ciaH) [Streptococcus sp. oral taxon 431 strain F0610 (5-114)]
MFKKIKKNWYAEDFSYFIRNFGVFTLIFSAMTLIILQVMHSSLYTSVDEKLLSLSKNPQDVIQLAVNRATEDVKDLGSAN
VAPASEKKPTVSSNTEVILLDSNLNQLVTGNRFLGLDKITFNKKDLNHIRQLHVQNSYGQDEIYRVILSEINIDSVSTNI
KYAAVLINTSQIEQTSQNNEQLIVVVMASFWILSIIASLYLARVSVKPLLESMQKQQSFVENASHELRTPLAVLQNRLET
LFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPELGEVEPAFFNTTFTNYEMIASENNRAFHFENRIH
RTIITDKLLLKQLMTILFDNAVKYTEEEGDIHFVIATTERNLYLSVADDGIGISAVDKKKIFDRFYRVDKARTRQKGGFG
LGLSLAKQIVDALKGTISVKDNKPHGTIFEVKIAIQTPSKRKNK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=170006 AXE83_RS06995 WP_060955914.1 1482913..1484247(-) (ciaH) [Streptococcus sp. oral taxon 431 strain F0610 (5-114)]
ATGTTTAAAAAAATTAAAAAGAATTGGTATGCGGAGGATTTCAGTTATTTTATCCGTAACTTTGGAGTATTTACTCTGAT
TTTCTCTGCTATGACCTTGATTATCTTGCAGGTTATGCACTCCAGTCTCTACACATCGGTGGATGAAAAACTCTTATCAC
TGAGCAAAAATCCTCAGGACGTTATTCAATTGGCAGTCAATCGTGCAACTGAGGACGTTAAGGATTTAGGTAGTGCCAAT
GTTGCTCCAGCTTCTGAAAAAAAACCAACGGTTAGTTCCAATACAGAAGTGATATTGTTAGATTCAAATTTGAATCAATT
AGTGACTGGCAACCGCTTTCTAGGTCTTGATAAGATTACTTTTAATAAAAAGGATTTGAATCATATTCGACAACTTCATG
TTCAGAATAGTTATGGTCAGGACGAGATTTACCGAGTGATTCTATCTGAAATAAATATCGATTCTGTCTCGACCAATATT
AAGTATGCAGCGGTTTTGATAAATACCAGTCAGATAGAGCAAACTAGTCAAAACAATGAGCAATTAATCGTGGTAGTCAT
GGCTAGCTTCTGGATTTTATCCATTATTGCCAGCCTTTATCTTGCGCGTGTCAGTGTTAAACCTTTACTTGAAAGCATGC
AAAAGCAACAGAGTTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCATTAGCTGTTCTGCAAAATCGACTAGAAACT
CTTTTCAGAAAACCTGAGGCAACTATTATGGAGTCAAGTGAGAGTATTGCTTCTAGTCTAGAAGAAGTTCGTAATATGCG
CTTTTTAACGACTAATCTCCTTAATTTAGCTCGTCGTGATGACGGCATTAAACCGGAATTAGGAGAGGTAGAGCCAGCCT
TCTTTAATACAACTTTTACCAACTATGAAATGATTGCGTCTGAAAATAACCGTGCTTTTCATTTTGAAAATCGCATCCAT
CGGACCATCATAACAGATAAGCTTCTTCTTAAACAACTGATGACTATCTTGTTTGACAATGCTGTCAAGTACACAGAAGA
AGAAGGAGATATCCATTTTGTCATTGCTACGACGGAGCGTAATCTCTATTTGTCAGTAGCTGATGATGGAATTGGTATTT
CTGCAGTAGATAAAAAGAAAATTTTTGATCGCTTTTACAGGGTTGATAAGGCTCGTACTCGGCAAAAAGGTGGTTTTGGG
TTAGGCTTATCCTTAGCCAAACAGATTGTCGATGCTCTTAAAGGAACCATCAGTGTCAAAGATAACAAACCTCATGGTAC
GATTTTTGAAGTAAAGATCGCTATCCAAACACCATCCAAGCGTAAAAATAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(326-433)

His Kinase A (phospho-acceptor) domain (HisKA)

(216-282)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A109W8Z1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

82.619

99.775

0.824
  ciaH Streptococcus pneumoniae D39

82.619

99.775

0.824
  ciaH Streptococcus pneumoniae R6

82.619

99.775

0.824
  ciaH Streptococcus pneumoniae TIGR4

82.619

99.775

0.824
  ciaH Streptococcus mutans UA159

54.965

97.523

0.536

Multiple sequence alignment