Detailed information NTG0166407

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SE1UMMC_RS08035
• Genome accession: NZ_CP013943
• Coordinates: 1591599..1592645 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain DAR1907
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1586599..1597645

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SE1UMMC_RS08005 (SE1UMMC_07610)	-	1586983..1588224 (-)	1242	WP_001832467.1	aminopeptidase	-
SE1UMMC_RS08010 (SE1UMMC_07615)	-	1588226..1588441 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
SE1UMMC_RS08015 (SE1UMMC_07620)	-	1588582..1589046 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
SE1UMMC_RS08020 (SE1UMMC_07625)	-	1589054..1589338 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
SE1UMMC_RS08025 (SE1UMMC_07630)	-	1589745..1590923 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
SE1UMMC_RS08030 (SE1UMMC_07635)	vraR	1590980..1591609 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
SE1UMMC_RS08035 (SE1UMMC_07640)	vraS	1591599..1592645 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
SE1UMMC_RS08040 (SE1UMMC_07645)	liaF	1592642..1593343 (-)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
SE1UMMC_RS08045 (SE1UMMC_07650)	-	1593358..1593744 (-)	387	WP_001830382.1	hypothetical protein	-
SE1UMMC_RS08050 (SE1UMMC_07655)	map	1593902..1594657 (-)	756	WP_002457092.1	type I methionyl aminopeptidase	-
SE1UMMC_RS08055 (SE1UMMC_07660)	-	1594831..1595817 (+)	987	WP_001830388.1	FUSC family protein	-
SE1UMMC_RS08060 (SE1UMMC_07665)	isaB	1595968..1596504 (-)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=166407 SE1UMMC_RS08035 WP_001830374.1 1591599..1592645(-) (vraS) [Staphylococcus epidermidis strain DAR1907]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=166407 SE1UMMC_RS08035 WP_001830374.1 1591599..1592645(-) (vraS) [Staphylococcus epidermidis strain DAR1907]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92