Detailed information
Bioinformatically predicted
Overview
| Name | comYB | Type | Machinery gene |
| Locus tag | AV644_RS01120 | Genome accession | NZ_CP013908 |
| Coordinates | 187974..189017 (+) | Length | 347 a.a. |
| NCBI ID | WP_223295889.1 | Uniprot ID | - |
| Organism | Streptococcus agalactiae strain GBS-M002 | ||
| Function | dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 189251..243369 | 187974..189017 | flank | 234 |
Gene organization within MGE regions
Location: 187974..243369
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AV644_RS01120 (AV644_01090) | comYB | 187974..189017 (+) | 1044 | WP_223295889.1 | competence type IV pilus assembly protein ComGB | Machinery gene |
| AV644_RS01125 (AV644_01095) | comGF | 189014..189469 (+) | 456 | WP_000793378.1 | competence type IV pilus minor pilin ComGF | - |
| AV644_RS01130 (AV644_01100) | comGG | 189447..189818 (+) | 372 | WP_000601104.1 | competence type IV pilus minor pilin ComGG | - |
| AV644_RS01135 (AV644_01105) | comYH | 189933..190907 (+) | 975 | WP_001008574.1 | class I SAM-dependent methyltransferase | Machinery gene |
| AV644_RS01140 (AV644_01110) | - | 190939..192132 (+) | 1194 | WP_000047534.1 | acetate kinase | - |
| AV644_RS01145 (AV644_01115) | - | 192284..192490 (+) | 207 | WP_000798241.1 | helix-turn-helix transcriptional regulator | - |
| AV644_RS01150 | - | 192549..192686 (+) | 138 | WP_001865900.1 | hypothetical protein | - |
| AV644_RS01155 (AV644_01120) | - | 192727..193182 (+) | 456 | WP_000905673.1 | hypothetical protein | - |
| AV644_RS01160 (AV644_01125) | - | 193251..193916 (+) | 666 | WP_000008113.1 | CPBP family intramembrane glutamic endopeptidase | - |
| AV644_RS01165 (AV644_01130) | proC | 193937..194707 (-) | 771 | WP_001865901.1 | pyrroline-5-carboxylate reductase | - |
| AV644_RS01170 (AV644_01135) | pepA | 194777..195844 (-) | 1068 | WP_001281321.1 | glutamyl aminopeptidase | - |
| AV644_RS01175 (AV644_01140) | - | 196029..196268 (-) | 240 | WP_000660180.1 | hypothetical protein | - |
| AV644_RS01180 (AV644_01145) | - | 196429..196713 (+) | 285 | WP_000791272.1 | DUF4651 domain-containing protein | - |
| AV644_RS01185 (AV644_01150) | - | 196710..197033 (+) | 324 | WP_000602781.1 | thioredoxin family protein | - |
| AV644_RS01190 (AV644_01155) | ytpR | 197066..197692 (+) | 627 | WP_000578328.1 | YtpR family tRNA-binding protein | - |
| AV644_RS01195 (AV644_01160) | - | 197746..198462 (-) | 717 | WP_000186185.1 | class I SAM-dependent methyltransferase | - |
| AV644_RS01200 (AV644_01165) | ssbA | 198543..198938 (+) | 396 | WP_000282447.1 | single-stranded DNA-binding protein | Machinery gene |
| AV644_RS01205 (AV644_01170) | - | 199062..199706 (+) | 645 | WP_000416612.1 | HAD family hydrolase | - |
| AV644_RS01210 (AV644_01175) | - | 199733..201478 (+) | 1746 | WP_000930334.1 | LytS/YhcK type 5TM receptor domain-containing protein | - |
| AV644_RS01215 (AV644_01180) | - | 201459..202199 (+) | 741 | WP_000697630.1 | LytR/AlgR family response regulator transcription factor | - |
| AV644_RS01220 (AV644_01185) | - | 202369..202824 (+) | 456 | WP_000683316.1 | CidA/LrgA family protein | - |
| AV644_RS01225 (AV644_01190) | lrgB | 202826..203554 (+) | 729 | WP_000421726.1 | antiholin-like protein LrgB | - |
| AV644_RS01235 (AV644_01195) | - | 203797..205425 (+) | 1629 | WP_000170504.1 | ABC transporter substrate-binding protein | - |
| AV644_RS01240 (AV644_01200) | - | 205538..206515 (+) | 978 | WP_000680645.1 | ABC transporter permease | - |
| AV644_RS01245 (AV644_01205) | - | 206512..207333 (+) | 822 | WP_000603397.1 | ABC transporter permease | - |
| AV644_RS01250 (AV644_01210) | - | 207345..208148 (+) | 804 | WP_000140984.1 | ABC transporter ATP-binding protein | - |
| AV644_RS01255 (AV644_01215) | - | 208132..208758 (+) | 627 | WP_000171309.1 | ABC transporter ATP-binding protein | - |
| AV644_RS01260 (AV644_01220) | treP | 209041..211071 (+) | 2031 | WP_000434616.1 | PTS system trehalose-specific EIIBC component | - |
| AV644_RS01265 (AV644_01225) | treC | 211293..212918 (+) | 1626 | WP_000151017.1 | alpha,alpha-phosphotrehalase | - |
| AV644_RS01270 (AV644_01230) | - | 213134..215170 (+) | 2037 | WP_000228183.1 | BglG family transcription antiterminator | - |
| AV644_RS01275 (AV644_01235) | - | 215173..215457 (+) | 285 | WP_000944235.1 | PTS sugar transporter subunit IIB | - |
| AV644_RS01280 (AV644_01240) | - | 215470..216825 (+) | 1356 | WP_000677358.1 | PTS ascorbate transporter subunit IIC | - |
| AV644_RS01285 (AV644_01245) | - | 216828..217685 (+) | 858 | WP_075316588.1 | transketolase | - |
| AV644_RS01290 (AV644_01250) | - | 217682..218611 (+) | 930 | WP_001203821.1 | transketolase family protein | - |
| AV644_RS01295 (AV644_01255) | - | 218720..219979 (+) | 1260 | WP_001203071.1 | ferric reductase-like transmembrane domain-containing protein | - |
| AV644_RS01300 (AV644_01260) | rpsO | 220067..220336 (+) | 270 | WP_001018249.1 | 30S ribosomal protein S15 | - |
| AV644_RS01305 (AV644_01265) | pnp | 220717..222846 (+) | 2130 | WP_000043850.1 | polyribonucleotide nucleotidyltransferase | - |
| AV644_RS01310 (AV644_01270) | - | 222848..223600 (+) | 753 | WP_000204782.1 | SseB family protein | - |
| AV644_RS01315 (AV644_01275) | cysE | 223609..224193 (+) | 585 | WP_000539954.1 | serine O-acetyltransferase | - |
| AV644_RS01320 (AV644_01280) | - | 224203..224385 (+) | 183 | WP_000656476.1 | lipoprotein | - |
| AV644_RS01325 (AV644_01285) | cysS | 224382..225725 (+) | 1344 | WP_000591131.1 | cysteine--tRNA ligase | - |
| AV644_RS01330 (AV644_01290) | - | 225718..226104 (+) | 387 | WP_000568029.1 | Mini-ribonuclease 3 | - |
| AV644_RS01335 (AV644_01295) | rlmB | 226207..226962 (+) | 756 | WP_000178026.1 | 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB | - |
| AV644_RS01340 (AV644_01300) | - | 226959..227477 (+) | 519 | WP_000716636.1 | NYN domain-containing protein | - |
| AV644_RS01345 (AV644_01305) | - | 227570..228430 (+) | 861 | WP_000143135.1 | DegV family protein | - |
| AV644_RS11105 | - | 228967..229086 (+) | 120 | Protein_206 | helix-turn-helix transcriptional regulator | - |
| AV644_RS01365 (AV644_01310) | rplM | 229311..229757 (+) | 447 | WP_001865567.1 | 50S ribosomal protein L13 | - |
| AV644_RS01370 (AV644_01315) | rpsI | 229778..230170 (+) | 393 | WP_000035940.1 | 30S ribosomal protein S9 | - |
| AV644_RS01375 (AV644_01320) | - | 230276..231499 (-) | 1224 | WP_017827915.1 | site-specific integrase | - |
| AV644_RS01380 (AV644_01325) | - | 231554..231826 (-) | 273 | WP_017827914.1 | helix-turn-helix domain-containing protein | - |
| AV644_RS01385 (AV644_01330) | - | 231938..232270 (-) | 333 | WP_017827913.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| AV644_RS01390 (AV644_01335) | - | 232257..232562 (-) | 306 | WP_017827912.1 | toxin-antitoxin system protein | - |
| AV644_RS01395 (AV644_01340) | - | 232619..233674 (-) | 1056 | WP_017827911.1 | phage tail tip lysozyme | - |
| AV644_RS01400 (AV644_01345) | - | 233683..233910 (-) | 228 | WP_017827910.1 | hypothetical protein | - |
| AV644_RS01405 (AV644_01350) | - | 233907..235838 (-) | 1932 | WP_017827909.1 | hypothetical protein | - |
| AV644_RS01410 (AV644_01355) | - | 235851..238370 (-) | 2520 | WP_075316589.1 | ATP-binding protein | - |
| AV644_RS01415 (AV644_01360) | - | 238381..238797 (-) | 417 | WP_075316590.1 | conjugal transfer protein | - |
| AV644_RS01420 (AV644_01365) | - | 238799..239026 (-) | 228 | WP_017827907.1 | hypothetical protein | - |
| AV644_RS01425 (AV644_01370) | - | 239043..240032 (-) | 990 | WP_017827906.1 | conjugal transfer protein | - |
| AV644_RS01430 (AV644_01375) | - | 240042..240596 (-) | 555 | WP_017827905.1 | hypothetical protein | - |
| AV644_RS01435 (AV644_01380) | - | 240617..241069 (-) | 453 | WP_017827904.1 | LPD11 domain-containing protein | - |
| AV644_RS01440 (AV644_01385) | - | 241079..241465 (-) | 387 | WP_017827903.1 | hypothetical protein | - |
| AV644_RS01445 (AV644_01390) | - | 241443..242675 (-) | 1233 | WP_017827902.1 | replication initiation factor domain-containing protein | - |
Sequence
Protein
Download Length: 347 a.a. Molecular weight: 39936.65 Da Isoelectric Point: 9.9002
>NTDB_id=165917 AV644_RS01120 WP_223295889.1 187974..189017(+) (comYB) [Streptococcus agalactiae strain GBS-M002]
MDKWISWLKKDISVRNRHKSKKLSLKKQRKVVQLFNNLFASGFSLTDMVTFLKRSKLLSDCYTDSMNKALLEGKDLSKML
GELGFSDTVITQVALADLHGNISRSLLKIESYLANLLLVRKKVIEVATYPLILLSFLVLIMIGLRNYLMPQLGENNFATR
LITNVPNIFLLLLAVVLIFSLIFYIIQKRLSRIKVACFLTTIPLVGSYVKLYLTAYYAREWGNLLSQGIELDQIVKVMQN
QKSKLFREIGYDMEEGFLSGKAFHQKVLDYPFFLTELSLMIEYGQVKAKLGTELDIYADEKWEDFFTKLARATQLIQPVI
FIFVALIIVMIYAAMLLPMYQNMEILS
MDKWISWLKKDISVRNRHKSKKLSLKKQRKVVQLFNNLFASGFSLTDMVTFLKRSKLLSDCYTDSMNKALLEGKDLSKML
GELGFSDTVITQVALADLHGNISRSLLKIESYLANLLLVRKKVIEVATYPLILLSFLVLIMIGLRNYLMPQLGENNFATR
LITNVPNIFLLLLAVVLIFSLIFYIIQKRLSRIKVACFLTTIPLVGSYVKLYLTAYYAREWGNLLSQGIELDQIVKVMQN
QKSKLFREIGYDMEEGFLSGKAFHQKVLDYPFFLTELSLMIEYGQVKAKLGTELDIYADEKWEDFFTKLARATQLIQPVI
FIFVALIIVMIYAAMLLPMYQNMEILS
Nucleotide
Download Length: 1044 bp
>NTDB_id=165917 AV644_RS01120 WP_223295889.1 187974..189017(+) (comYB) [Streptococcus agalactiae strain GBS-M002]
ATAGACAAGTGGATATCTTGGCTGAAGAAGGACATATCAGTAAGAAACAGGCACAAGTCGAAAAAATTATCCCTCAAGAA
ACAACGGAAAGTAGTCCAACTTTTTAATAATCTTTTTGCTAGTGGTTTTTCTTTAACTGATATGGTCACCTTCTTAAAGA
GGAGTAAGTTATTGTCTGATTGTTATACAGATAGTATGAATAAGGCATTATTAGAGGGAAAAGATTTATCAAAAATGTTA
GGAGAGTTAGGTTTTTCTGACACTGTTATCACACAGGTTGCATTAGCTGATTTGCATGGTAACATTTCAAGGAGCCTACT
AAAGATTGAGTCTTATTTAGCTAATCTTTTGTTAGTTAGAAAAAAAGTAATAGAAGTAGCTACTTACCCATTGATATTAT
TGTCTTTTCTGGTGCTAATTATGATTGGCCTTAGGAATTATTTAATGCCCCAATTAGGAGAAAATAATTTTGCAACTAGA
CTGATTACAAATGTGCCGAATATTTTCTTATTACTTTTAGCAGTTGTACTTATTTTTAGTTTAATATTTTATATTATTCA
AAAGCGATTGTCGCGCATTAAAGTAGCTTGTTTTTTAACAACAATTCCCTTAGTTGGATCATATGTTAAGCTTTATTTAA
CTGCTTACTATGCCCGTGAGTGGGGAAATTTATTAAGTCAAGGTATTGAATTGGACCAAATTGTTAAAGTAATGCAAAAT
CAGAAATCCAAACTTTTTAGGGAAATAGGATATGACATGGAAGAAGGTTTTCTATCAGGTAAAGCATTTCACCAAAAAGT
ATTAGACTATCCGTTTTTCTTAACTGAGCTTAGTTTAATGATTGAATATGGCCAAGTTAAGGCGAAATTAGGAACAGAGT
TAGATATATATGCTGATGAGAAGTGGGAGGATTTTTTTACAAAATTAGCTAGAGCGACCCAGTTAATCCAACCCGTTATT
TTTATTTTTGTAGCTCTTATCATTGTTATGATTTATGCAGCAATGCTGTTACCAATGTATCAAAATATGGAGATATTATC
ATGA
ATAGACAAGTGGATATCTTGGCTGAAGAAGGACATATCAGTAAGAAACAGGCACAAGTCGAAAAAATTATCCCTCAAGAA
ACAACGGAAAGTAGTCCAACTTTTTAATAATCTTTTTGCTAGTGGTTTTTCTTTAACTGATATGGTCACCTTCTTAAAGA
GGAGTAAGTTATTGTCTGATTGTTATACAGATAGTATGAATAAGGCATTATTAGAGGGAAAAGATTTATCAAAAATGTTA
GGAGAGTTAGGTTTTTCTGACACTGTTATCACACAGGTTGCATTAGCTGATTTGCATGGTAACATTTCAAGGAGCCTACT
AAAGATTGAGTCTTATTTAGCTAATCTTTTGTTAGTTAGAAAAAAAGTAATAGAAGTAGCTACTTACCCATTGATATTAT
TGTCTTTTCTGGTGCTAATTATGATTGGCCTTAGGAATTATTTAATGCCCCAATTAGGAGAAAATAATTTTGCAACTAGA
CTGATTACAAATGTGCCGAATATTTTCTTATTACTTTTAGCAGTTGTACTTATTTTTAGTTTAATATTTTATATTATTCA
AAAGCGATTGTCGCGCATTAAAGTAGCTTGTTTTTTAACAACAATTCCCTTAGTTGGATCATATGTTAAGCTTTATTTAA
CTGCTTACTATGCCCGTGAGTGGGGAAATTTATTAAGTCAAGGTATTGAATTGGACCAAATTGTTAAAGTAATGCAAAAT
CAGAAATCCAAACTTTTTAGGGAAATAGGATATGACATGGAAGAAGGTTTTCTATCAGGTAAAGCATTTCACCAAAAAGT
ATTAGACTATCCGTTTTTCTTAACTGAGCTTAGTTTAATGATTGAATATGGCCAAGTTAAGGCGAAATTAGGAACAGAGT
TAGATATATATGCTGATGAGAAGTGGGAGGATTTTTTTACAAAATTAGCTAGAGCGACCCAGTTAATCCAACCCGTTATT
TTTATTTTTGTAGCTCTTATCATTGTTATGATTTATGCAGCAATGCTGTTACCAATGTATCAAAATATGGAGATATTATC
ATGA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comYB | Streptococcus mutans UA140 |
62.17 |
98.271 |
0.611 |
| comYB | Streptococcus mutans UA159 |
61.877 |
98.271 |
0.608 |
| comYB | Streptococcus gordonii str. Challis substr. CH1 |
56.305 |
98.271 |
0.553 |
| comGB/cglB | Streptococcus mitis NCTC 12261 |
55.224 |
96.542 |
0.533 |
| comGB/cglB | Streptococcus mitis SK321 |
54.627 |
96.542 |
0.527 |
| comGB/cglB | Streptococcus pneumoniae Rx1 |
53.731 |
96.542 |
0.519 |
| comGB/cglB | Streptococcus pneumoniae D39 |
53.731 |
96.542 |
0.519 |
| comGB/cglB | Streptococcus pneumoniae R6 |
53.731 |
96.542 |
0.519 |
| comGB/cglB | Streptococcus pneumoniae TIGR4 |
53.731 |
96.542 |
0.519 |
| comGB | Lactococcus lactis subsp. cremoris KW2 |
50.148 |
97.118 |
0.487 |