Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   MGAS11027_RS00585 Genome accession   NZ_CP013838
Coordinates   95893..96831 (+) Length   312 a.a.
NCBI ID   WP_023612548.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain MGAS11027     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 90893..101831
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS11027_RS00575 (MGAS11027_0120) rpoC 91642..95283 (+) 3642 WP_063510175.1 DNA-directed RNA polymerase subunit beta' -
  MGAS11027_RS00580 (MGAS11027_0121) - 95435..95800 (+) 366 WP_002986560.1 DUF1033 family protein -
  MGAS11027_RS00585 (MGAS11027_0122) comYA 95893..96831 (+) 939 WP_023612548.1 competence type IV pilus ATPase ComGA Machinery gene
  MGAS11027_RS00590 (MGAS11027_0123) comYB 96767..97801 (+) 1035 WP_011054115.1 competence type IV pilus assembly protein ComGB Machinery gene
  MGAS11027_RS00595 (MGAS11027_0124) comYC 97803..98129 (+) 327 WP_063510176.1 competence type IV pilus major pilin ComGC Machinery gene
  MGAS11027_RS00600 (MGAS11027_0125) comGD 98104..98532 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  MGAS11027_RS00605 (MGAS11027_0126) comGE 98489..98773 (+) 285 WP_063510177.1 competence type IV pilus minor pilin ComGE -
  MGAS11027_RS00610 (MGAS11027_0127) comYF 98766..99200 (+) 435 WP_063510178.1 competence type IV pilus minor pilin ComGF Machinery gene
  MGAS11027_RS00615 (MGAS11027_0128) comGG 99184..99510 (+) 327 WP_002992739.1 competence type IV pilus minor pilin ComGG -
  MGAS11027_RS00620 (MGAS11027_0129) comYH 99608..100561 (+) 954 WP_063510179.1 class I SAM-dependent methyltransferase Machinery gene
  MGAS11027_RS00625 (MGAS11027_0130) - 100620..101816 (+) 1197 WP_063510180.1 acetate kinase -

Sequence

Protein


Download         Length: 312 a.a.        Molecular weight: 35045.27 Da        Isoelectric Point: 8.5799

>NTDB_id=164991 MGAS11027_RS00585 WP_023612548.1 95893..96831(+) (comYA) [Streptococcus pyogenes strain MGAS11027]
MVQALAKAILAKAEQVQAQDIYILPRADQYDLFLRIGDERRLVDVYQSDRMAPLVSHFKFVAGMIVGEKRRCQVGSCDYK
LSKDKQLSLRLSSVGDYRGQESLVIRLLHHQNKSVHYWFDGLTKVANQVGGRGLYLFAGPVGSGKTTLMYQLISNYHQEA
QVISIEDPVEIKNHQILQLQVNDDIGMTYDNLIKLSLRHRPDILVIGEIRDSQTARAVIRASLTGAMVFSTVHAKSISGV
YARLLELGVTKAELSNCLALIAYQRLLNGGALIDSTQNEFEYYSSSNWNQQIDQLLEAGHLNPKQAKLEKII

Nucleotide


Download         Length: 939 bp        

>NTDB_id=164991 MGAS11027_RS00585 WP_023612548.1 95893..96831(+) (comYA) [Streptococcus pyogenes strain MGAS11027]
ATGGTACAAGCATTAGCAAAAGCTATTCTAGCAAAAGCTGAACAGGTTCAGGCACAAGATATTTATATTTTGCCAAGAGC
AGATCAATATGATCTTTTTTTACGAATAGGAGATGAAAGGAGATTAGTTGATGTTTATCAGAGCGATCGGATGGCTCCTC
TTGTTAGTCACTTTAAATTCGTTGCAGGAATGATAGTTGGTGAAAAGAGACGTTGTCAGGTGGGTTCATGTGATTATAAG
CTCAGTAAAGATAAGCAGTTATCTTTGCGCTTATCTAGCGTGGGTGATTATCGCGGGCAAGAAAGCTTAGTGATTCGTCT
GCTTCATCATCAAAATAAAAGTGTACATTATTGGTTTGATGGATTGACAAAAGTAGCCAATCAGGTTGGCGGTAGAGGGT
TGTATTTATTTGCAGGACCAGTTGGGTCTGGGAAGACAACCTTGATGTACCAGCTGATTTCGAATTATCATCAAGAAGCA
CAGGTTATTAGTATAGAAGATCCTGTAGAAATTAAAAATCACCAGATTTTACAATTACAAGTGAATGATGATATTGGTAT
GACTTATGACAATTTGATCAAACTGTCTTTACGCCATCGACCAGATATTTTAGTTATTGGTGAGATTCGAGATAGTCAAA
CAGCAAGAGCCGTTATTAGGGCTAGTCTAACAGGTGCCATGGTTTTTTCAACGGTTCACGCTAAAAGTATCTCGGGTGTT
TATGCAAGATTGTTAGAACTTGGTGTAACGAAAGCAGAACTGTCTAATTGCTTAGCATTAATTGCTTACCAAAGGTTACT
TAATGGAGGAGCATTGATTGACTCTACTCAAAACGAATTTGAATATTATTCCTCATCGAACTGGAATCAACAAATTGATC
AGCTTCTTGAGGCAGGACATCTCAATCCCAAGCAAGCTAAGCTTGAAAAAATTATCTAG

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-267)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus mutans UA159

61.415

99.679

0.612
  comYA Streptococcus mutans UA140

61.415

99.679

0.612
  comYA Streptococcus gordonii str. Challis substr. CH1

60.45

99.679

0.603
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

60.323

99.359

0.599
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

59.164

99.679

0.59
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

58.521

99.679

0.583
  comGA/cglA/cilD Streptococcus pneumoniae D39

58.521

99.679

0.583
  comGA/cglA/cilD Streptococcus pneumoniae R6

58.521

99.679

0.583
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

58.521

99.679

0.583
  comGA Lactococcus lactis subsp. cremoris KW2

50.482

99.679

0.503
  comGA Latilactobacillus sakei subsp. sakei 23K

39.655

92.949

0.369

Multiple sequence alignment