Detailed information NTG0157340

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: AN924_RS02560
• Genome accession: NZ_CP012731
• Coordinates: 521610..523847 (-)
• Length: 745 a.a.
• NCBI ID: WP_009909666.1
• Uniprot ID: A0A7Y6RP41
• Organism: Streptococcus suis strain 90-1330
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 516610..528847

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AN924_RS02530 (AN924_05320)	tmk	516716..517354 (-)	639	WP_002935358.1	dTMP kinase	-
AN924_RS02535 (AN924_05330)	-	517529..518395 (+)	867	WP_002935357.1	YitT family protein	-
AN924_RS02540 (AN924_05340)	-	518432..519703 (-)	1272	WP_002935355.1	toxic anion resistance protein	-
AN924_RS02545 (AN924_05350)	-	519709..520536 (-)	828	WP_002935354.1	hypothetical protein	-
AN924_RS02550 (AN924_05360)	-	520630..521286 (-)	657	WP_002935353.1	CBS domain-containing protein	-
AN924_RS11170 (AN924_05370)	-	521465..521608 (-)	144	WP_002935351.1	transposase	-
AN924_RS02560 (AN924_05380)	comEC/celB	521610..523847 (-)	2238	WP_009909666.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
AN924_RS02565 (AN924_05410)	-	523831..524493 (-)	663	WP_009909665.1	helix-hairpin-helix domain-containing protein	-
AN924_RS02570 (AN924_05420)	-	524561..525307 (-)	747	WP_013730321.1	lysophospholipid acyltransferase family protein	-
AN924_RS02575 (AN924_05430)	-	525453..526898 (+)	1446	WP_013730320.1	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	-
AN924_RS02580 (AN924_05440)	-	527051..527851 (+)	801	WP_013730319.1	ABC transporter ATP-binding protein	-
AN924_RS02585 (AN924_05450)	-	527848..528777 (+)	930	WP_009909659.1	ABC transporter substrate-binding protein	-

Sequence

Protein

• Length: 745 a.a.
• Molecular weight: 84156.93 Da
• Isoelectric Point: 7.3957

>NTDB_id=157340 AN924_RS02560 WP_009909666.1 521610..523847(-) (comEC/celB) [Streptococcus suis strain 90-1330]
MSRLSKLPCQPVHLAVLAVAAYFAVHSFSLLTMGLFSLLLAVFGVRQGKTVFLKTLPLLALCGLFFGYQKVQWERADQSA
TEQVTTVQVIPDTIDINGDSLSFRGRADGQTYQVFYKLTSQEEQTYFQKLTGLVQLEVEAEISLPAGQRNFKGFDYQAYL
KTQGIYRTVKITAIKKIVPVQSWNVFDWLSNWRRQALVYVKTNFPAPMSHYMTGLLFGDLDSDFDQMSDLYSSLGIIHLF
ALSGMQVGFVIDKFRWILLRLGLTKETVDKLQIPFSLVYASLTGFSVSVVRSLVQKILGNLGLRKLDNFAVTVFVCLLIL
PRFLLTAGGVLTFTYAFLLTVFDFEDLGQVKKAAVESLSISLGILPVLMTYFYAFQPLSILLTFAFSFVFDVLLLPGLSV
IFLLSPIVKITWVNGFFVFMEKIIVWVADLGLRPWILGKPSELVLLLLLVSLFLLYDFHRRKKWLLGLSLVLALLFFITK
HPLENEVTVVDIGQGDSIFLRDMRGRTVLIDVGGRVDFAAKEAWQERPRQANAERTLIPYLHSRGVDRIDSLVLTHTDTD
HVGDVLEVAKQVQIGRIYVSPGSLTVPDFVATLKEINVPVHVVEVGERLPIFDSYLEVLYPDGTGDGGNNDSIVLYGRLL
KTNFLFTGDLEQGELDLIESYPNLPVDVLKAGHHGSKGSSYPEFLDHIEAKIALVSAGENNRYKHPHQETLERFDSRNIQ
VYRTDQQGAIRFRGWREWRIETVRR

Nucleotide

• Length: 2238 bp

>NTDB_id=157340 AN924_RS02560 WP_009909666.1 521610..523847(-) (comEC/celB) [Streptococcus suis strain 90-1330]
ATGTCACGGTTGAGTAAGCTCCCCTGCCAGCCCGTTCACCTGGCAGTCTTGGCGGTGGCGGCCTACTTTGCAGTCCATTC
TTTTTCCCTCTTGACAATGGGCCTGTTCAGTCTGTTACTGGCTGTCTTTGGTGTTCGGCAAGGTAAGACGGTTTTCCTCA
AAACGCTGCCGCTTTTAGCTCTATGTGGTCTCTTTTTCGGCTACCAAAAGGTCCAATGGGAGCGGGCAGACCAGTCAGCC
ACAGAGCAAGTCACAACTGTGCAGGTCATTCCAGATACTATTGACATTAACGGGGACAGCCTGTCTTTTCGTGGTCGGGC
TGACGGACAAACCTATCAGGTTTTCTATAAATTAACCAGTCAGGAGGAACAGACCTATTTTCAAAAGCTGACAGGTTTGG
TCCAGCTTGAAGTGGAAGCAGAGATCAGTCTGCCAGCTGGTCAGCGGAATTTCAAGGGTTTTGACTATCAGGCCTACCTG
AAAACACAGGGTATTTATCGGACGGTCAAGATTACGGCAATCAAGAAGATTGTCCCAGTCCAGTCTTGGAATGTCTTTGA
CTGGTTGTCAAACTGGCGGAGGCAGGCTTTGGTTTATGTCAAAACCAATTTTCCGGCTCCCATGAGCCACTACATGACAG
GGCTCTTGTTTGGGGACTTGGATAGTGATTTTGACCAGATGAGTGACCTCTATTCCAGTTTGGGTATCATTCATCTCTTT
GCCCTGTCTGGTATGCAGGTGGGCTTTGTCATCGACAAGTTTCGCTGGATTTTACTGCGTTTGGGCTTGACCAAAGAAAC
GGTTGATAAATTACAAATTCCCTTTTCCCTTGTCTATGCGAGCTTGACAGGTTTTTCCGTATCGGTGGTGCGGTCTTTGG
TTCAAAAAATTTTGGGTAATCTGGGCTTGCGGAAGTTGGATAACTTTGCGGTGACAGTTTTTGTCTGTCTGTTGATACTG
CCCCGATTTCTGCTGACAGCTGGTGGTGTCCTGACCTTTACCTATGCTTTTTTGCTGACGGTTTTTGATTTTGAGGACTT
GGGGCAGGTCAAAAAGGCTGCGGTGGAAAGTCTCAGTATTTCACTTGGGATTTTGCCAGTGCTCATGACCTATTTCTATG
CCTTTCAGCCCCTGTCTATCCTCTTGACCTTTGCCTTTTCTTTTGTCTTTGATGTCCTACTCTTGCCAGGCTTGTCAGTC
ATTTTTCTCCTGTCGCCAATCGTCAAGATTACTTGGGTCAACGGATTTTTTGTCTTTATGGAAAAAATCATTGTCTGGGT
GGCGGATTTGGGATTGCGACCTTGGATACTGGGCAAGCCGTCTGAGCTGGTCCTTTTGCTCTTGCTGGTCAGCCTCTTCT
TACTCTACGATTTCCACAGGAGAAAGAAATGGCTTCTAGGACTGAGCTTGGTCCTCGCTCTGCTATTTTTCATAACCAAA
CACCCGCTGGAAAACGAGGTGACGGTGGTGGACATCGGGCAGGGGGACAGCATCTTTTTGCGGGATATGCGGGGGCGGAC
GGTCCTGATTGATGTGGGCGGACGAGTTGATTTTGCGGCCAAGGAAGCGTGGCAGGAGCGGCCTCGGCAGGCAAATGCAG
AGCGGACTTTGATTCCCTATCTGCATAGTCGGGGTGTGGATAGGATTGATAGTTTAGTCCTGACCCACACCGACACAGAC
CATGTGGGGGATGTGCTGGAAGTGGCGAAGCAGGTCCAGATTGGTCGGATTTACGTGTCGCCGGGAAGCCTGACGGTGCC
TGACTTTGTAGCCACCTTGAAAGAAATTAATGTCCCTGTTCATGTTGTTGAGGTGGGCGAACGCTTACCAATTTTTGACT
CTTACCTGGAAGTCCTTTATCCAGATGGGACAGGAGACGGTGGCAATAATGACTCCATTGTCCTTTATGGTCGCTTGCTG
AAAACTAATTTTCTCTTTACAGGGGACTTGGAGCAGGGGGAGTTGGACTTGATAGAATCTTATCCTAACCTGCCTGTCGA
TGTCCTCAAAGCCGGTCACCACGGCTCCAAAGGTTCTTCCTATCCTGAATTTTTGGACCATATCGAAGCCAAGATTGCCT
TGGTATCTGCTGGAGAAAACAACCGCTACAAGCATCCTCACCAAGAAACCTTGGAACGATTTGATAGTCGCAATATCCAA
GTCTATCGTACAGACCAGCAAGGAGCCATTCGCTTCCGAGGTTGGAGGGAGTGGAGGATTGAAACGGTGAGGAGGTAA

Domains

Predicted by InterproScan.

• Competence protein (Competence) (215-461)

• Domain of unknown function (DUF4131) (DUF4131) (29-175)

• Metallo-beta-lactamase superfamily (Lactamase_B) (493-698)

3D structure

• AlphaFold DB: A0A7Y6RP41

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	53.992	99.195	0.536
comEC/celB	Streptococcus mitis NCTC 12261	52.861	98.523	0.521
comEC/celB	Streptococcus pneumoniae TIGR4	51.973	98.658	0.513
comEC/celB	Streptococcus pneumoniae Rx1	51.701	98.658	0.51
comEC/celB	Streptococcus pneumoniae D39	51.701	98.658	0.51
comEC/celB	Streptococcus pneumoniae R6	51.701	98.658	0.51
comEC	Lactococcus lactis subsp. cremoris KW2	48.865	100	0.491