Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   A9E99_RS06455 Genome accession   NZ_CP015928
Coordinates   1430447..1431124 (-) Length   225 a.a.
NCBI ID   WP_010947023.1    Uniprot ID   Q5ZVZ6
Organism   Legionella pneumophila strain Philadelphia_1_CDC     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1425447..1436124
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A9E99_RS06430 (A9E99_06425) ruvC 1425642..1426166 (+) 525 WP_010947018.1 crossover junction endodeoxyribonuclease RuvC -
  A9E99_RS06435 (A9E99_06430) ruvA 1426163..1426762 (+) 600 WP_010947019.1 Holliday junction branch migration protein RuvA -
  A9E99_RS06440 (A9E99_06435) - 1426812..1427132 (+) 321 WP_010947020.1 hypothetical protein -
  A9E99_RS06445 (A9E99_06440) lem8 1427165..1428751 (-) 1587 WP_010947021.1 Dot/Icm T4SS effector Lem8 -
  A9E99_RS06450 (A9E99_06445) - 1429035..1430450 (-) 1416 WP_010947022.1 ATP-binding protein -
  A9E99_RS06455 (A9E99_06450) ciaR 1430447..1431124 (-) 678 WP_010947023.1 response regulator Regulator
  A9E99_RS06460 (A9E99_06455) - 1431185..1431730 (-) 546 WP_010947024.1 septation protein A -
  A9E99_RS06465 (A9E99_06460) - 1431973..1433412 (-) 1440 WP_010947025.1 lytic transglycosylase -
  A9E99_RS06475 (A9E99_06470) gloB 1433527..1434291 (-) 765 WP_010947026.1 hydroxyacylglutathione hydrolase -
  A9E99_RS06480 (A9E99_06475) - 1434295..1435143 (-) 849 WP_015444565.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
  A9E99_RS06485 (A9E99_06480) - 1435419..1435628 (+) 210 WP_011213609.1 hypothetical protein -

Sequence

Protein


Download         Length: 225 a.a.        Molecular weight: 25175.73 Da        Isoelectric Point: 5.1590

>NTDB_id=156599 A9E99_RS06455 WP_010947023.1 1430447..1431124(-) (ciaR) [Legionella pneumophila strain Philadelphia_1_CDC]
MRLLLVEDDELLGDAVKAGLTQFGYVVDWLKDGEAARAALKSESFELIILDLGLPKLSGLSLLQNIRHDGNSTPVIILTA
RESIEDRVKGLDSGADDYHIKPFDLNELSARIRALVRRSQGRADSVLQYKNITLDPAAHSVFVDDVLVNVPRREFALLQK
LLENSGQVLSREQLMQSIYGWEEDVDSNALEVHIHNLRKKLNANFIRTIRGVGYMAEKNDSVLLS

Nucleotide


Download         Length: 678 bp        

>NTDB_id=156599 A9E99_RS06455 WP_010947023.1 1430447..1431124(-) (ciaR) [Legionella pneumophila strain Philadelphia_1_CDC]
ATGAGATTATTACTTGTTGAAGACGATGAACTGCTTGGCGATGCAGTAAAAGCCGGACTGACACAATTTGGTTATGTTGT
TGACTGGCTAAAAGATGGCGAAGCTGCTCGGGCGGCTCTCAAATCAGAGTCTTTTGAATTAATTATTCTTGACTTGGGAT
TACCTAAATTATCCGGTTTATCATTATTGCAAAACATCAGACATGATGGAAATAGCACACCTGTGATTATTCTTACAGCT
CGAGAATCAATAGAAGATCGGGTAAAAGGCTTAGATAGCGGTGCTGACGATTATCATATTAAGCCTTTTGATTTAAACGA
ATTAAGTGCAAGGATTAGAGCATTGGTAAGGCGCTCTCAGGGCAGAGCTGATTCCGTGTTGCAATATAAAAATATTACTC
TCGATCCTGCTGCTCATTCTGTCTTCGTGGATGATGTACTCGTCAATGTTCCAAGAAGAGAATTTGCTCTATTGCAGAAA
TTACTTGAAAACAGTGGCCAGGTTTTATCTCGAGAACAATTAATGCAGAGTATTTATGGCTGGGAAGAAGACGTGGACAG
TAATGCTCTCGAAGTTCATATACATAATTTACGTAAAAAACTTAACGCAAACTTTATCCGCACTATACGTGGTGTAGGAT
ATATGGCTGAAAAAAATGACAGTGTACTTCTATCGTGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(148-215)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q5ZVZ6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

37.9

97.333

0.369
  ciaR Streptococcus pneumoniae D39

37.9

97.333

0.369
  ciaR Streptococcus pneumoniae R6

37.9

97.333

0.369
  ciaR Streptococcus pneumoniae TIGR4

37.9

97.333

0.369
  micA Streptococcus pneumoniae Cp1015

35.345

100

0.364
  ciaR Streptococcus mutans UA159

37.443

97.333

0.364