Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   RN80_RS07620 Genome accession   NZ_CP012646
Coordinates   1555460..1556794 (-) Length   444 a.a.
NCBI ID   WP_060628533.1    Uniprot ID   -
Organism   Streptococcus mitis strain KCOM 1350 (= ChDC B183)     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1550460..1561794
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RN80_RS07600 (RN80_07615) - 1551974..1552903 (-) 930 WP_060628529.1 peptidase U32 family protein -
  RN80_RS07605 (RN80_07620) - 1553030..1553710 (-) 681 WP_060628530.1 ABC transporter ATP-binding protein -
  RN80_RS07610 (RN80_07625) - 1553724..1554779 (-) 1056 WP_060628531.1 ABC transporter permease -
  RN80_RS07615 (RN80_07630) - 1555139..1555426 (+) 288 WP_060628532.1 DUF3270 domain-containing protein -
  RN80_RS07620 (RN80_07635) ciaH 1555460..1556794 (-) 1335 WP_060628533.1 two-component system sensor histidine kinase CiaH Regulator
  RN80_RS07625 (RN80_07640) ciaR 1556784..1557458 (-) 675 WP_060628534.1 two-component system response regulator CiaR Regulator
  RN80_RS07630 (RN80_07645) - 1557567..1560113 (-) 2547 WP_060628535.1 M1 family metallopeptidase -
  RN80_RS07635 (RN80_07650) - 1560235..1560675 (-) 441 Protein_1455 ASCH domain-containing protein -
  RN80_RS07640 (RN80_07655) - 1560635..1561519 (-) 885 WP_060628536.1 putative PEP-binding protein -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50692.42 Da        Isoelectric Point: 9.1616

>NTDB_id=156033 RN80_RS07620 WP_060628533.1 1555460..1556794(-) (ciaH) [Streptococcus mitis strain KCOM 1350 (= ChDC B183)]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAVNRATEEIKDLENAA
TDTSKTEVKPNVSSNTEVILFDKNFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRMILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEKLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENDRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAIKYTEEDGEIDFMISATDRNLYLLVSDNGVGISAEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTITVKDNKPKGTIFEVKIAIHTPSKKKK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=156033 RN80_RS07620 WP_060628533.1 1555460..1556794(-) (ciaH) [Streptococcus mitis strain KCOM 1350 (= ChDC B183)]
ATGTTCAGTAAACTAAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATTCGCAACTTCGGTGTCTTTACCCTGAT
TTTCTCTACCATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTCTATACTTCGGTGGATGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTTGCTGTAAATAGGGCAACAGAAGAGATTAAAGATTTAGAGAATGCCGCT
ACAGATACTAGCAAGACTGAAGTAAAACCCAATGTCAGTTCCAATACCGAGGTTATTCTTTTTGATAAGAATTTTACACA
GCTCCTTTCTGGAAATCGATTTTTGGGATTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGTCATATCTATCAGATTC
AAGTTTTTAATAGCTATGGACAAGAAGAAATCTATCGCATGATTTTGATGGAAACGAATATCAGTTCAGTTTCAACCAAT
ATCAAGTATGCGGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCCAGTCAAAAGCATGAGAAATTGATTGTGGTCGT
GATGGCAAGTTTCTGGATTCTGTCTTTGCTTGCCAGTCTCTATCTAGCTAGAGTCAGTGTTCGTCCTCTGCTTGAGAGCA
TGCAGAAGCAACAGTCCTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTCCGTAAGCCAGAAGCAACCATTATGGATGTGAGTGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGGTTTTTGACGACGAACTTGTTGAATTTAGCTCGTAGAGATGATGGGATTAAGCCGGAACTTGCAGAAGTTCCAACCA
GTTTTTTCAATACGACTTTCACAAACTATGAAATGATTGCTTCGGAAAATGACCGTGTCTTCCGTTTTGAAAATCGCATC
CATCGAACGATTGTCACAGATCAACTTTTACTAAAACAACTGATGACCATCCTATTTGATAATGCTATCAAATATACTGA
GGAGGATGGTGAAATTGATTTTATGATTTCAGCGACTGATCGTAATCTGTATTTACTTGTGTCTGATAATGGAGTCGGTA
TTTCCGCGGAAGATAAGAAGAAAATTTTTGATCGTTTTTATCGAGTGGACAAGGCTAGAACCCGCCAAAAAGGTGGTTTT
GGTTTAGGTTTATCCCTAGCCAAGCAAATTGTAGATGCCCTAAAAGGAACCATTACTGTTAAAGATAATAAACCAAAGGG
AACAATCTTTGAAGTGAAGATTGCCATCCACACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

96.171

100

0.962
  ciaH Streptococcus pneumoniae D39

96.171

100

0.962
  ciaH Streptococcus pneumoniae R6

96.171

100

0.962
  ciaH Streptococcus pneumoniae TIGR4

96.171

100

0.962
  ciaH Streptococcus mutans UA159

55.402

97.973

0.543

Multiple sequence alignment