Detailed information NTG0154100

Bioinformatically predicted

Overview

• Name: pilA
• Type: Machinery gene
• Locus tag: DE10444_RS00220
• Genome accession: NZ_CP012392
• Coordinates: 40191..41456 (+)
• Length: 421 a.a.
• NCBI ID: WP_002215249.1
• Uniprot ID: A0A425AK53
• Organism: Neisseria meningitidis strain DE10444
• Function: assembly of type IV pilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 35191..46456

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DE10444_RS00200 (DE10444_0037)	-	35922..36923 (+)	1002	WP_002223261.1	thiamine ABC transporter substrate-binding protein	-
DE10444_RS00205 (DE10444_0038)	-	37017..37865 (+)	849	WP_002215243.1	mechanosensitive ion channel family protein	-
DE10444_RS00210 (DE10444_0039)	-	37891..38376 (+)	486	WP_002215245.1	CinA family protein	-
DE10444_RS00215 (DE10444_0040)	msrAB	38478..40046 (-)	1569	WP_002224229.1	bifunctional peptide-methionine (S)-S-oxide reductase MsrA/peptide-methionine (R)-S-oxide reductase MsrB	-
DE10444_RS00220 (DE10444_0041)	pilA	40191..41456 (+)	1266	WP_002215249.1	signal recognition particle-docking protein FtsY	Machinery gene
DE10444_RS00225 (DE10444_0042)	pilC	42067..45189 (+)	3123	WP_411172360.1	PilC family type IV pilus tip adhesin	Machinery gene

Sequence

Protein

• Length: 421 a.a.
• Molecular weight: 45185.50 Da
• Isoelectric Point: 4.5585

>NTDB_id=154100 DE10444_RS00220 WP_002215249.1 40191..41456(+) (pilA) [Neisseria meningitidis strain DE10444]
MFSFFRRKKKQETPAPEEAQVQETAAKAESEVTQIVENIKEEVESLTESVKGQVESAVETVSGAVEQVKEAVAEMLSEAE
EAAEKAAEQVEAAKEAIAETVGEAVGQVQEAVATTEEHKLGWAARLKQGLTKSRDKMAKSLAGVFGGGQIDEDLYEELET
VLITSDMGMEATEYLMKDVRDRVSLKGLKDGNELRGALKEALYDLIKPLEKPLVLPETKEPFVIMLAGINGAGKTTSIGK
LAKYFQAQGKSVLLAAGDTFRAAAREQLQAWGERNNVTVISQTTGDSAAVCFDAVQAAKARGIDIVLADTAGRLPTQLHL
MEEIKKVKRVLQKAMPDAPHEIIVVLDANIGQNAVNQVKAFDDALGLTGLIVTKLDGTAKGGILAALASDRPVPVRYIGV
GEGIDDLRPFDARAFVDALLD

Nucleotide

• Length: 1266 bp

>NTDB_id=154100 DE10444_RS00220 WP_002215249.1 40191..41456(+) (pilA) [Neisseria meningitidis strain DE10444]
ATGTTCAGCTTCTTCCGTCGCAAGAAAAAACAGGAAACGCCGGCTCCCGAGGAGGCTCAAGTTCAGGAAACTGCAGCAAA
AGCAGAATCCGAAGTTACTCAAATAGTTGAAAATATTAAAGAAGAAGTCGAATCTTTAACGGAAAGCGTCAAAGGGCAGG
TCGAATCGGCTGTTGAAACCGTCAGCGGTGCGGTTGAACAAGTAAAGGAAGCCGTTGCCGAGATGCTGTCTGAAGCAGAG
GAAGCGGCGGAAAAAGCAGCGGAACAAGTCGAAGCGGCAAAAGAAGCCATTGCCGAAACCGTCGGCGAGGCTGTCGGGCA
AGTTCAAGAAGCCGTTGCAACAACTGAAGAACACAAGCTCGGTTGGGCGGCGCGTTTGAAACAAGGTTTGACCAAATCGC
GCGACAAAATGGCGAAATCGCTGGCGGGCGTGTTCGGCGGCGGACAAATCGACGAAGATTTGTACGAAGAGCTGGAAACC
GTGCTGATTACCAGCGATATGGGCATGGAAGCCACCGAATACCTGATGAAAGACGTGCGCGACCGCGTCAGCCTCAAAGG
GCTGAAAGACGGCAACGAATTGCGCGGCGCGCTGAAAGAAGCCTTGTACGACCTGATTAAGCCTCTAGAGAAACCGCTGG
TTTTGCCCGAAACCAAAGAGCCGTTTGTCATCATGCTTGCTGGCATCAACGGCGCGGGCAAAACCACATCCATCGGCAAA
CTCGCCAAATATTTCCAAGCGCAGGGCAAATCTGTGCTGCTTGCCGCCGGCGATACTTTCCGCGCCGCCGCGCGTGAGCA
GCTTCAAGCTTGGGGCGAACGCAACAACGTAACCGTGATTTCGCAAACCACGGGCGATTCCGCCGCCGTGTGCTTCGATG
CCGTCCAAGCCGCCAAAGCGCGCGGCATCGACATTGTGCTGGCCGACACCGCCGGCCGCCTGCCCACGCAGCTTCACTTG
ATGGAAGAAATCAAAAAAGTGAAACGCGTGCTGCAAAAAGCCATGCCCGACGCGCCGCACGAAATCATCGTCGTGCTTGA
TGCCAACATCGGGCAAAACGCCGTCAACCAAGTCAAAGCCTTTGACGACGCATTAGGGCTGACCGGTTTAATCGTGACCA
AACTCGACGGCACGGCAAAAGGCGGCATCCTCGCCGCGCTTGCCTCCGACCGCCCCGTCCCCGTCCGCTACATCGGCGTG
GGCGAAGGCATAGACGATTTGCGCCCGTTTGACGCGCGCGCGTTTGTGGACGCACTGCTGGATTGA

Domains

Predicted by InterproScan.

• SRP54-type protein, GTPase domain (SRP54) (221-420)

• SRP54-type protein, helical bundle domain (SRP54_N) (136-202)

3D structure

• AlphaFold DB: A0A425AK53

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
pilA	Neisseria gonorrhoeae MS11	94.062	100	0.941