Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   SpyM6JRS4_RS01480 Genome accession   NZ_CP011414
Coordinates   283469..284155 (+) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes JRS4     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 278469..289155
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SpyM6JRS4_RS01455 (SpyM6JRS4_01450) ktrB 278611..279987 (-) 1377 WP_047149526.1 potassium uptake transporter channel subunit KtrB -
  SpyM6JRS4_RS01460 (SpyM6JRS4_01455) rsmG 280072..280785 (-) 714 WP_011184187.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  SpyM6JRS4_RS01465 (SpyM6JRS4_01460) - 280935..281492 (+) 558 WP_002985956.1 LemA family protein -
  SpyM6JRS4_RS01470 (SpyM6JRS4_01465) htpX 281539..282435 (+) 897 WP_002985953.1 zinc metalloprotease HtpX -
  SpyM6JRS4_RS01475 (SpyM6JRS4_01470) - 282669..283202 (+) 534 WP_011054200.1 DUF177 domain-containing protein -
  SpyM6JRS4_RS01480 (SpyM6JRS4_01475) covR 283469..284155 (+) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  SpyM6JRS4_RS01485 (SpyM6JRS4_01480) covS 284161..285663 (+) 1503 WP_002985946.1 two-component system sensor histidine kinase CovS -
  SpyM6JRS4_RS01490 (SpyM6JRS4_01485) nrdR 285878..286372 (+) 495 WP_011184190.1 transcriptional regulator NrdR -
  SpyM6JRS4_RS01495 (SpyM6JRS4_01490) - 286356..287531 (+) 1176 WP_011184191.1 replication initiation and membrane attachment family protein -
  SpyM6JRS4_RS01500 (SpyM6JRS4_01495) dnaI 287532..288434 (+) 903 WP_002991016.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=145741 SpyM6JRS4_RS01480 WP_002991052.1 283469..284155(+) (covR) [Streptococcus pyogenes JRS4]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=145741 SpyM6JRS4_RS01480 WP_002991052.1 283469..284155(+) (covR) [Streptococcus pyogenes JRS4]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGCGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGTATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGCGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGCTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment