Detailed information NTG0145724

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: SpyM6JRS4_RS00330
• Genome accession: NZ_CP011414
• Coordinates: 54236..55147 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes JRS4
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 49236..60147

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SpyM6JRS4_RS00310 (SpyM6JRS4_00310)	purE	49685..50176 (+)	492	WP_021340277.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
SpyM6JRS4_RS00315 (SpyM6JRS4_00315)	purK	50163..51236 (+)	1074	WP_011888523.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
SpyM6JRS4_RS00320 (SpyM6JRS4_00320)	-	51257..52597 (+)	1341	WP_011184068.1	hypothetical protein	-
SpyM6JRS4_RS00325 (SpyM6JRS4_00325)	purB	52813..54105 (+)	1293	WP_011184069.1	adenylosuccinate lyase	-
SpyM6JRS4_RS00330 (SpyM6JRS4_00330)	comR	54236..55147 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
SpyM6JRS4_RS09910	comS	55231..55326 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
SpyM6JRS4_RS00335 (SpyM6JRS4_00335)	ruvB	55373..56371 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
SpyM6JRS4_RS00340 (SpyM6JRS4_00340)	-	56509..56946 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
SpyM6JRS4_RS00345 (SpyM6JRS4_00345)	-	56969..57370 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
SpyM6JRS4_RS00350 (SpyM6JRS4_00350)	-	57367..59142 (+)	1776	WP_011184071.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=145724 SpyM6JRS4_RS00330 WP_002986681.1 54236..55147(+) (comR) [Streptococcus pyogenes JRS4]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=145724 SpyM6JRS4_RS00330 WP_002986681.1 54236..55147(+) (comR) [Streptococcus pyogenes JRS4]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462