Detailed information NTG0131196

Bioinformatically predicted

Overview

• Name: crp
• Type: Regulator
• Locus tag: ADJ80_RS03940
• Genome accession: NZ_CP012067
• Coordinates: 787811..788455 (-)
• Length: 214 a.a.
• NCBI ID: WP_050693032.1
• Uniprot ID: A0AAP7GYZ1
• Organism: Aggregatibacter aphrophilus strain W10433
• Function: promote expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 782811..793455

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ADJ80_RS03910 (ADJ80_03930)	-	783030..783272 (-)	243	WP_050693027.1	hypothetical protein	-
ADJ80_RS03915 (ADJ80_03935)	-	783284..783613 (-)	330	WP_050693028.1	hypothetical protein	-
ADJ80_RS03920 (ADJ80_03940)	-	783613..784530 (-)	918	WP_050693029.1	AAA family ATPase	-
ADJ80_RS03925 (ADJ80_03945)	-	784554..786518 (-)	1965	WP_050693030.1	transposase domain-containing protein	-
ADJ80_RS03930 (ADJ80_03950)	-	786527..786739 (-)	213	WP_048750443.1	helix-turn-helix domain-containing protein	-
ADJ80_RS03935 (ADJ80_03955)	-	786816..787511 (+)	696	WP_050693031.1	helix-turn-helix domain-containing protein	-
ADJ80_RS03940 (ADJ80_03960)	crp	787811..788455 (-)	645	WP_050693032.1	cAMP-activated global transcriptional regulator CRP	Regulator
ADJ80_RS03945 (ADJ80_03965)	-	788493..788711 (-)	219	WP_050693033.1	YheU family protein	-
ADJ80_RS03950 (ADJ80_03970)	slmA	788735..789319 (-)	585	Protein_767	nucleoid occlusion factor SlmA	-
ADJ80_RS03955 (ADJ80_03975)	dut	789334..789789 (-)	456	WP_050693035.1	dUTP diphosphatase	-
ADJ80_RS03960 (ADJ80_03980)	coaBC	789942..791141 (-)	1200	WP_050693036.1	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC	-
ADJ80_RS03965 (ADJ80_03985)	radC	791319..791978 (+)	660	WP_050693037.1	RadC family protein	Machinery gene
ADJ80_RS03970 (ADJ80_03990)	rpmB	792189..792425 (+)	237	WP_005542826.1	50S ribosomal protein L28	-
ADJ80_RS03975 (ADJ80_03995)	rpmG	792437..792607 (+)	171	WP_005544948.1	50S ribosomal protein L33	-

Sequence

Protein

• Length: 214 a.a.
• Molecular weight: 24135.78 Da
• Isoelectric Point: 7.3995

>NTDB_id=131196 ADJ80_RS03940 WP_050693032.1 787811..788455(-) (crp) [Aggregatibacter aphrophilus strain W10433]
MQEQNAQTTQPTDPTLEWFLSHCHIHKYPSKSTLINAGEKAETLYYLIQGSVSVMVKDEDGKEMILTYLGQGDFFGEAGL
FEEGQLRSAWIKAKSACEVAEISYRKFRQLIQANPEILMYLTAQLARRLQNTSRQVSNLAFLDVTGRIAQTLLNLAKMPE
AMTHPDGMQIKITRQEIGQMVGCSRETVGRILKMLEDQHLISAHGKTIVVYGTR

Nucleotide

• Length: 645 bp

>NTDB_id=131196 ADJ80_RS03940 WP_050693032.1 787811..788455(-) (crp) [Aggregatibacter aphrophilus strain W10433]
GTGCAGGAACAAAACGCACAAACTACACAACCCACGGATCCAACTTTGGAGTGGTTTTTATCACATTGCCATATTCATAA
ATATCCATCTAAAAGCACATTAATCAATGCCGGCGAAAAAGCCGAAACACTTTATTATTTAATCCAAGGCTCCGTCTCCG
TTATGGTGAAAGACGAAGATGGAAAAGAGATGATTCTCACTTATTTAGGCCAAGGGGATTTCTTTGGTGAAGCGGGCTTA
TTTGAAGAAGGTCAGCTCCGTTCCGCATGGATCAAGGCTAAAAGTGCCTGTGAAGTGGCTGAAATCTCTTATCGCAAATT
CCGCCAACTCATTCAGGCTAATCCTGAAATTTTAATGTATTTAACTGCGCAGCTTGCCCGACGATTACAAAACACCTCGC
GCCAAGTAAGCAATTTGGCTTTCTTAGATGTCACCGGGCGTATCGCGCAAACTTTATTAAATCTAGCCAAAATGCCGGAA
GCCATGACACACCCGGATGGGATGCAAATTAAAATCACCCGTCAGGAAATTGGCCAAATGGTAGGTTGCTCCCGCGAAAC
CGTTGGCCGAATTTTAAAAATGTTGGAAGATCAACATCTCATATCCGCTCACGGCAAGACTATTGTCGTTTACGGCACCC
GTTAA

Domains

Predicted by InterProScan.

• Crp-like helix-turn-helix domain (HTH_Crp_2) (146-210)

• Cyclic nucleotide-binding domain (cNMP_binding) (27-114)

3D structure

• AlphaFold DB: A0AAP7GYZ1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
crp	Haemophilus influenzae Rd KW20	82.178	94.393	0.776
crp	Vibrio cholerae strain A1552	81.773	94.86	0.776
crp	Acinetobacter baumannii D1279779	47.739	92.991	0.444