Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   DP15_RS05345 Genome accession   NZ_CP008926
Coordinates   1055950..1056861 (+) Length   303 a.a.
NCBI ID   WP_002986681.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain ATCC 19615     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1050950..1061861
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DP15_RS05330 (DP15_1100) purK 1051319..1052392 (+) 1074 WP_038432714.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  DP15_RS05335 (DP15_1101) - 1052408..1054216 (+) 1809 WP_038432716.1 ATP-binding protein -
  DP15_RS05340 (DP15_1102) purB 1054526..1055818 (+) 1293 WP_038432718.1 adenylosuccinate lyase -
  DP15_RS05345 (DP15_1103) comR 1055950..1056861 (+) 912 WP_002986681.1 transcriptional regulator Rgg4/ComR Regulator
  DP15_RS10315 (DP15_1104) comS 1056945..1057040 (+) 96 WP_198462994.1 quorum-sensing system DWW-type pheromone Regulator
  DP15_RS05350 (DP15_1105) ruvB 1057087..1058085 (+) 999 WP_002986679.1 Holliday junction branch migration DNA helicase RuvB -
  DP15_RS05355 (DP15_1106) - 1058223..1058660 (+) 438 WP_002994668.1 low molecular weight protein-tyrosine-phosphatase -
  DP15_RS05360 (DP15_1107) - 1058683..1059084 (+) 402 WP_002986671.1 MORN repeat-containing protein -
  DP15_RS05365 (DP15_1108) - 1059081..1060856 (+) 1776 WP_038432721.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35757.27 Da        Isoelectric Point: 4.4858

>NTDB_id=125785 DP15_RS05345 WP_002986681.1 1055950..1056861(+) (comR) [Streptococcus pyogenes strain ATCC 19615]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 912 bp        

>NTDB_id=125785 DP15_RS05345 WP_002986681.1 1055950..1056861(+) (comR) [Streptococcus pyogenes strain ATCC 19615]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATTATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(12-64)

ComR tetratricopeptide (ComR_TPR)

(73-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

100

100

1
  comR Streptococcus pyogenes MGAS315

58.472

99.34

0.581
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

51.37

96.37

0.495
  comR Streptococcus mutans UA159

46.358

99.67

0.462

Multiple sequence alignment