Detailed information NTG0124111

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: SP5448_RS00260
• Genome accession: NZ_CP008776
• Coordinates: 47323..48234 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain 5448
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 42323..53234

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SP5448_RS00240 (SP5448_00250)	purE	42660..43151 (+)	492	WP_015055884.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
SP5448_RS00245 (SP5448_00255)	purK	43138..44211 (+)	1074	WP_015055885.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
SP5448_RS00250 (SP5448_00260)	-	44238..45881 (+)	1644	WP_010921779.1	AIPR family protein	-
SP5448_RS00255 (SP5448_00265)	purB	45899..47191 (+)	1293	WP_010921780.1	adenylosuccinate lyase	-
SP5448_RS00260 (SP5448_00270)	comR	47323..48234 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
SP5448_RS09970	comS	48318..48413 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
SP5448_RS00265 (SP5448_00280)	ruvB	48460..49458 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
SP5448_RS00270 (SP5448_00285)	-	49596..50033 (+)	438	WP_002994668.1	low molecular weight phosphotyrosine protein phosphatase	-
SP5448_RS00275 (SP5448_00290)	-	50056..50457 (+)	402	WP_010921781.1	MORN repeat-containing protein	-
SP5448_RS00280 (SP5448_00295)	-	50454..52229 (+)	1776	WP_010921782.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=124111 SP5448_RS00260 WP_002986681.1 47323..48234(+) (comR) [Streptococcus pyogenes strain 5448]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=124111 SP5448_RS00260 WP_002986681.1 47323..48234(+) (comR) [Streptococcus pyogenes strain 5448]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462