Detailed information    

experimental Experimentally validated

Overview

Name   ctsD   Type   Machinery gene
Locus tag   CJJ81176_RS07065 Genome accession   NC_008787
Coordinates   1385987..1387399 (-) Length   470 a.a.
NCBI ID   WP_002856543.1    Uniprot ID   A0A2R4CZP6
Organism   Campylobacter jejuni subsp. jejuni 81-176     
Function   type II secretion system/type IV pilin; DNA uptake   
DNA binding and uptake

Function

Mutants of C. jejuni lacking the PSTC proteins CtsD, CtsE, CtsF, and CtsG decrease DNA uptake to background levels.


Genomic Context

Location: 1380987..1392399
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CJJ81176_RS07040 (CJJ81176_1462) - 1381310..1382074 (+) 765 WP_002855301.1 TSUP family transporter -
  CJJ81176_RS07045 (CJJ81176_1463) ctsF 1382071..1383249 (-) 1179 WP_002869197.1 type II secretion system F family protein Machinery gene
  CJJ81176_RS07050 (CJJ81176_1464) ctsE 1383246..1384805 (-) 1560 WP_011812800.1 GspE/PulE family protein Machinery gene
  CJJ81176_RS07055 (CJJ81176_1465) ctsX 1384795..1385382 (-) 588 WP_002851370.1 membrane protein Machinery gene
  CJJ81176_RS07060 (CJJ81176_1466) ctsP 1385386..1385994 (-) 609 WP_011812801.1 ATP-binding protein Machinery gene
  CJJ81176_RS07065 (CJJ81176_1467) ctsD 1385987..1387399 (-) 1413 WP_002856543.1 pilus (MSHA type) biogenesis protein MshL Machinery gene
  CJJ81176_RS07070 (CJJ81176_1468) ctsR 1387377..1387688 (-) 312 WP_002855438.1 hypothetical protein Machinery gene
  CJJ81176_RS07075 (CJJ81176_1469) nifJ 1387712..1391272 (-) 3561 WP_002869199.1 pyruvate:ferredoxin (flavodoxin) oxidoreductase -
  CJJ81176_RS07080 (CJJ81176_1470) - 1391365..1392006 (-) 642 WP_002869201.1 HAD family hydrolase -

Sequence

Protein


Download         Length: 470 a.a.        Molecular weight: 53094.65 Da        Isoelectric Point: 6.6184

>NTDB_id=1226 CJJ81176_RS07065 WP_002856543.1 1385987..1387399(-) (ctsD) [Campylobacter jejuni subsp. jejuni 81-176]
MIRLILINILFCHYLYALDCQKRLFDISINEKLSIQESLDELAKYCSFSIIVKDKIAKEKLEILQNSVNIHQMSLDEIFN
FFIKEHDLSYDFDGKILRISGINTKIFKISYITSIREGQSITKASVDAKPRQSEYSGSFDDAEDNMIKSMEKFDFWQNIE
KEIIVLLKNSHEDYEAKTPIINPNAGLIIVTGTNSQLKSVKNYLQKLENRLKKQVIIDVSILAVSLNENHSSGINWQNFN
IGLNSQVNNENSFIQFQNGQGFVKNLGLRANLNFDSIINFLSQNGKTSVLSNPKLMALNNQQAIISVGDTINYQVKESSK
GTENGTTVSESYNNYSIFVGILLNILPEISDDGKIMLRINPSLSDFKYPEDNKRQKEPRTIAPDTIQKKLSSVVQVENNQ
TLILGGLISHDKSNEKNSINFLSKIPILGSLFKGEVLNSKATEIVFIITPSIVDSVNAPSLKDLGFKHYE

Nucleotide


Download         Length: 1413 bp        

>NTDB_id=1226 CJJ81176_RS07065 WP_002856543.1 1385987..1387399(-) (ctsD) [Campylobacter jejuni subsp. jejuni 81-176]
ATGATAAGATTAATATTAATTAACATTCTTTTTTGCCATTATCTTTATGCTTTAGATTGTCAAAAGCGTCTTTTTGATAT
CAGTATTAATGAAAAATTAAGCATACAAGAAAGTCTTGATGAGCTTGCAAAATATTGTTCTTTTAGTATTATTGTTAAAG
ATAAAATTGCCAAAGAAAAATTAGAAATATTGCAAAACTCTGTCAATATTCATCAAATGAGTTTAGACGAAATTTTTAAT
TTTTTTATCAAAGAGCATGATCTTAGCTATGATTTTGATGGTAAAATTTTAAGAATTTCAGGCATTAATACGAAGATTTT
TAAGATAAGTTATATCACTTCTATCAGAGAAGGACAAAGTATAACTAAAGCGTCTGTAGACGCTAAACCAAGGCAAAGTG
AATATAGCGGTAGTTTTGATGACGCAGAAGACAATATGATTAAAAGTATGGAAAAATTTGATTTTTGGCAAAATATAGAA
AAAGAGATTATTGTATTATTAAAAAATTCTCATGAAGATTATGAGGCTAAAACTCCCATTATAAATCCCAATGCAGGTCT
TATTATAGTAACTGGAACAAATTCTCAGTTAAAAAGTGTGAAAAATTATTTGCAAAAACTAGAAAATCGTCTTAAAAAAC
AAGTTATTATCGATGTTAGCATACTTGCTGTGAGTTTAAATGAAAACCATTCTAGTGGGATTAATTGGCAAAATTTTAAT
ATAGGTTTAAATTCGCAAGTAAATAATGAAAATTCTTTTATTCAGTTTCAAAATGGGCAAGGTTTTGTTAAGAATTTGGG
TTTAAGGGCGAATTTAAATTTTGATTCTATTATTAACTTTCTTTCTCAAAATGGAAAAACTAGCGTGCTTTCTAATCCAA
AGCTTATGGCTTTAAATAACCAACAAGCCATTATTTCTGTAGGTGATACTATAAATTATCAAGTTAAAGAAAGTTCTAAA
GGCACTGAAAATGGGACTACTGTTAGTGAAAGTTATAACAATTATTCTATTTTTGTAGGCATTTTACTCAATATCTTGCC
TGAAATTTCTGATGATGGAAAAATAATGCTCAGGATTAATCCAAGCTTAAGTGATTTTAAGTATCCAGAAGATAATAAAC
GACAAAAAGAACCAAGAACTATTGCTCCTGATACCATACAAAAAAAGCTTTCTAGTGTTGTGCAAGTAGAGAATAATCAA
ACTTTAATTTTAGGTGGATTGATTTCTCACGATAAATCTAATGAGAAAAATTCTATCAATTTTCTATCAAAAATTCCAAT
CCTAGGTTCTTTGTTTAAAGGAGAAGTTTTAAATTCTAAAGCAACTGAAATTGTTTTTATTATCACTCCAAGTATAGTAG
ATAGTGTAAATGCTCCAAGTCTTAAAGATCTAGGATTTAAGCATTATGAGTAA

Domains

Predicted by InterproScan.

Bacterial type II and III secretion system protein (Secretin)

(281-454)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2R4CZP6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value

References

[1] Rebecca S Wiesner et al. (2003) Natural transformation of Campylobacter jejuni requires components of a type II secretion system. Journal of Bacteriology 185(18):5408-18. [PMID: 12949093]