Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DK93_RS06970 Genome accession   NZ_CP007562
Coordinates   1418152..1418838 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NGAS327     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1413152..1423838
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DK93_RS06950 (DK93_07165) dnaI 1413873..1414775 (-) 903 WP_002991016.1 primosomal protein DnaI -
  DK93_RS06955 (DK93_07170) - 1414776..1415951 (-) 1176 WP_009880401.1 replication initiation and membrane attachment family protein -
  DK93_RS06960 (DK93_07175) nrdR 1415935..1416429 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  DK93_RS06965 (DK93_07180) covS 1416644..1418146 (-) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  DK93_RS06970 (DK93_07185) covR 1418152..1418838 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  DK93_RS06975 (DK93_07190) - 1419105..1419638 (-) 534 WP_014635288.1 YceD family protein -
  DK93_RS06980 (DK93_07195) htpX 1419872..1420768 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  DK93_RS06985 (DK93_07200) - 1420815..1421372 (-) 558 WP_038431211.1 LemA family protein -
  DK93_RS06990 (DK93_07205) rsmG 1421522..1422235 (+) 714 WP_014407313.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DK93_RS06995 (DK93_07210) ktrB 1422319..1423695 (+) 1377 WP_032459855.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=120959 DK93_RS06970 WP_002991052.1 1418152..1418838(-) (covR) [Streptococcus pyogenes strain NGAS327]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=120959 DK93_RS06970 WP_002991052.1 1418152..1418838(-) (covR) [Streptococcus pyogenes strain NGAS327]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGTATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment