Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   DI45_RS01595 Genome accession   NZ_CP007560
Coordinates   297478..298164 (+) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NGAS743     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 292478..303164
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DI45_RS01570 (DI45_01630) ktrB 292621..293997 (-) 1377 WP_032459855.1 potassium uptake transporter channel subunit KtrB -
  DI45_RS01575 (DI45_01635) rsmG 294081..294794 (-) 714 WP_014407313.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  DI45_RS01580 (DI45_01640) - 294944..295501 (+) 558 WP_002985956.1 LemA family protein -
  DI45_RS01585 (DI45_01645) htpX 295548..296444 (+) 897 WP_047235158.1 zinc metalloprotease HtpX -
  DI45_RS01590 (DI45_01650) - 296678..297211 (+) 534 WP_011054200.1 YceD family protein -
  DI45_RS01595 (DI45_01655) covR 297478..298164 (+) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  DI45_RS01600 (DI45_01660) covS 298170..299672 (+) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  DI45_RS01605 (DI45_01665) nrdR 299887..300381 (+) 495 WP_002985941.1 transcriptional regulator NrdR -
  DI45_RS01610 (DI45_01670) - 300365..301540 (+) 1176 WP_002991019.1 replication initiation and membrane attachment family protein -
  DI45_RS01615 (DI45_01675) dnaI 301541..302443 (+) 903 WP_002985938.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=120828 DI45_RS01595 WP_002991052.1 297478..298164(+) (covR) [Streptococcus pyogenes strain NGAS743]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=120828 DI45_RS01595 WP_002991052.1 297478..298164(+) (covR) [Streptococcus pyogenes strain NGAS743]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAACGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment