Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   SPAP1_RS08400 Genome accession   NZ_CP007537
Coordinates   1622921..1623607 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain AP1     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1617921..1628607
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPAP1_RS08380 (SPAP1_08370) dnaI 1618641..1619543 (-) 903 WP_002991016.1 primosomal protein DnaI -
  SPAP1_RS08385 (SPAP1_08375) - 1619544..1620719 (-) 1176 WP_002991019.1 replication initiation and membrane attachment family protein -
  SPAP1_RS08390 (SPAP1_08380) nrdR 1620703..1621197 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  SPAP1_RS08395 (SPAP1_08385) covS 1621412..1622915 (-) 1504 Protein_1630 two-component system sensor histidine kinase CovS -
  SPAP1_RS08400 (SPAP1_08390) covR 1622921..1623607 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  SPAP1_RS08405 (SPAP1_08395) - 1623874..1624407 (-) 534 WP_011054200.1 DUF177 domain-containing protein -
  SPAP1_RS08410 (SPAP1_08400) htpX 1624641..1625537 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  SPAP1_RS08415 (SPAP1_08405) - 1625584..1626141 (-) 558 WP_002985956.1 LemA family protein -
  SPAP1_RS08420 (SPAP1_08410) rsmG 1626291..1627004 (+) 714 WP_010921904.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  SPAP1_RS08425 (SPAP1_08415) ktrB 1627089..1628465 (+) 1377 WP_023605004.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=120645 SPAP1_RS08400 WP_002991052.1 1622921..1623607(-) (covR) [Streptococcus pyogenes strain AP1]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=120645 SPAP1_RS08400 WP_002991052.1 1622921..1623607(-) (covR) [Streptococcus pyogenes strain AP1]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment