Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   SPAP1_RS00260 Genome accession   NZ_CP007537
Coordinates   47324..48235 (+) Length   303 a.a.
NCBI ID   WP_029714263.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain AP1     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 42324..53235
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPAP1_RS00240 (SPAP1_00240) purE 42661..43152 (+) 492 WP_002987716.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  SPAP1_RS00245 (SPAP1_00245) purK 43139..44212 (+) 1074 WP_029714261.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  SPAP1_RS00250 (SPAP1_00250) - 44239..45882 (+) 1644 WP_010921779.1 AIPR family protein -
  SPAP1_RS00255 (SPAP1_00255) purB 45900..47192 (+) 1293 WP_010921780.1 adenylosuccinate lyase -
  SPAP1_RS00260 (SPAP1_00260) comR 47324..48235 (+) 912 WP_029714263.1 transcriptional regulator Rgg4/ComR Regulator
  SPAP1_RS10615 comS 48319..48414 (+) 96 WP_198462994.1 quorum-sensing system DWW-type pheromone Regulator
  SPAP1_RS00265 (SPAP1_00265) ruvB 48461..49459 (+) 999 WP_002986679.1 Holliday junction branch migration DNA helicase RuvB -
  SPAP1_RS00270 (SPAP1_00270) - 49597..50034 (+) 438 WP_002994668.1 low molecular weight phosphotyrosine protein phosphatase -
  SPAP1_RS00275 (SPAP1_00275) - 50057..50458 (+) 402 WP_010921781.1 MORN repeat-containing protein -
  SPAP1_RS00280 (SPAP1_00280) - 50455..52230 (+) 1776 WP_010921782.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35787.30 Da        Isoelectric Point: 4.4858

>NTDB_id=120596 SPAP1_RS00260 WP_029714263.1 47324..48235(+) (comR) [Streptococcus pyogenes strain AP1]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQTTLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 912 bp        

>NTDB_id=120596 SPAP1_RS00260 WP_029714263.1 47324..48235(+) (comR) [Streptococcus pyogenes strain AP1]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGACAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

ComR tetratricopeptide (ComR_TPR)

(73-296)

Helix-turn-helix (HTH_3)

(12-64)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

99.67

100

0.997
  comR Streptococcus pyogenes MGAS315

58.14

99.34

0.578
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

51.37

96.37

0.495
  comR Streptococcus mutans UA159

46.358

99.67

0.462

Multiple sequence alignment