Detailed information    

insolico Bioinformatically predicted

Overview

Name   pilC   Type   Machinery gene
Locus tag   NTHI723_RS06935 Genome accession   NZ_CP007472
Coordinates   1390261..1391481 (+) Length   406 a.a.
NCBI ID   WP_011271971.1    Uniprot ID   Q4QNP6
Organism   Haemophilus influenzae strain 723     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1385261..1396481
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NTHI723_RS06915 (NTHI723_01391) corC 1386223..1387122 (-) 900 WP_044364861.1 CNNM family magnesium/cobalt transport protein CorC -
  NTHI723_RS06920 (NTHI723_01392) ampD 1387755..1388309 (-) 555 WP_044364862.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
  NTHI723_RS06925 (NTHI723_01393) pilA 1388424..1388873 (+) 450 WP_044364865.1 prepilin-type N-terminal cleavage/methylation domain-containing protein Machinery gene
  NTHI723_RS06930 (NTHI723_01394) pilB 1388870..1390264 (+) 1395 WP_044364868.1 GspE/PulE family protein Machinery gene
  NTHI723_RS06935 (NTHI723_01395) pilC 1390261..1391481 (+) 1221 WP_011271971.1 type II secretion system F family protein Machinery gene
  NTHI723_RS06940 (NTHI723_01396) pilD 1391478..1392170 (+) 693 WP_038440789.1 A24 family peptidase Machinery gene
  NTHI723_RS06945 (NTHI723_01397) rho 1392224..1393486 (-) 1263 WP_005629550.1 transcription termination factor Rho -
  NTHI723_RS06950 (NTHI723_01398) metJ 1393734..1394051 (+) 318 WP_005631186.1 met regulon transcriptional regulator MetJ -
  NTHI723_RS06955 (NTHI723_01399) cueR 1394065..1394451 (-) 387 WP_005663006.1 Cu(I)-responsive transcriptional regulator -
  NTHI723_RS06960 (NTHI723_01400) - 1394528..1394734 (+) 207 WP_012054944.1 heavy-metal-associated domain-containing protein -
  NTHI723_RS06965 (NTHI723_01401) - 1394820..1395026 (+) 207 WP_005648955.1 heavy-metal-associated domain-containing protein -
  NTHI723_RS06970 (NTHI723_01402) - 1395112..1395318 (+) 207 WP_012054944.1 heavy-metal-associated domain-containing protein -
  NTHI723_RS06975 (NTHI723_01403) - 1395404..1395610 (+) 207 WP_005631184.1 heavy-metal-associated domain-containing protein -

Sequence

Protein


Download         Length: 406 a.a.        Molecular weight: 46259.57 Da        Isoelectric Point: 10.0444

>NTDB_id=119784 NTHI723_RS06935 WP_011271971.1 1390261..1391481(+) (pilC) [Haemophilus influenzae strain 723]
MTKKLFYYQGSNALNQKQKGSIIADTKQQAHFQLISRGLTHIKLQQNWQFGAKPKNSEISELLNQLATLLQSVIPLKNSL
QILQQNCTQIMLNKWLERLLQSIESGLAFSQAIEQQGKYLTQQEIQLIQVGEMTGKLAVVCKKIATHRSQSLALQRKLQK
IMLYPSMVLGISLLLTLALLLFIAPQFAEMYSGNNAELPTITAILLSISNFLKQNIGILLFFVLSFFLFYYFYLKRQTWF
HQKKNQLISITPIFGTIQKLSRLVNFSQSLQIMLQAGVPLNQALDSFLPRTQTWQTKKTLVNDMVLDKEVRSILQWVSQG
YAFSNSVSSDLFPMEAQQMLQIGEQSGKLALMLEHIADNYQEKLNHQIDLLSQMLEPLMMVIIGSLIGIIMMGMYLPIFN
MGSVIQ

Nucleotide


Download         Length: 1221 bp        

>NTDB_id=119784 NTHI723_RS06935 WP_011271971.1 1390261..1391481(+) (pilC) [Haemophilus influenzae strain 723]
ATGACTAAAAAACTCTTTTATTATCAAGGTAGTAACGCATTAAATCAGAAACAAAAAGGCTCAATTATTGCGGATACGAA
ACAACAAGCGCACTTTCAGTTAATAAGCCGCGGGCTTACTCACATCAAATTACAACAAAACTGGCAATTTGGGGCAAAAC
CCAAAAATTCAGAAATCAGTGAATTACTCAATCAATTAGCGACATTGCTACAGTCCGTAATTCCGTTAAAAAACAGCCTA
CAAATTTTGCAACAAAATTGTACTCAAATTATGCTCAACAAATGGCTTGAACGACTGCTTCAATCCATTGAATCTGGCTT
AGCATTCTCACAAGCCATTGAACAACAAGGAAAATATCTCACACAACAAGAAATTCAACTGATTCAAGTGGGAGAAATGA
CAGGAAAACTTGCCGTAGTTTGTAAAAAAATAGCCACGCACCGTAGTCAATCTTTGGCTTTACAACGCAAATTACAGAAA
ATTATGTTATATCCCTCAATGGTATTGGGAATTTCTCTATTATTGACACTCGCATTACTGCTTTTTATCGCGCCTCAATT
TGCTGAAATGTACAGTGGCAATAATGCGGAGTTACCAACAATAACCGCAATATTGCTCTCAATATCTAATTTCCTTAAGC
AAAATATTGGCATTTTGCTATTTTTCGTTTTGAGTTTTTTTCTATTTTATTATTTCTATCTAAAACGCCAGACTTGGTTT
CATCAAAAGAAAAATCAACTTATTTCTATCACGCCTATTTTTGGCACAATTCAAAAGCTTTCACGTTTAGTGAACTTTAG
TCAAAGTTTACAAATTATGTTGCAGGCCGGCGTACCGCTTAATCAGGCACTAGACAGTTTTCTTCCTCGCACACAAACTT
GGCAAACCAAGAAAACGCTTGTAAACGATATGGTATTAGATAAAGAAGTGCGGTCAATTTTGCAATGGGTTTCTCAAGGC
TATGCGTTTTCTAATAGCGTAAGTAGCGATCTTTTCCCGATGGAAGCACAACAAATGCTACAAATTGGCGAACAAAGCGG
AAAACTCGCTTTGATGCTAGAGCATATCGCAGATAATTACCAAGAAAAACTTAATCATCAAATTGACTTACTCTCACAAA
TGCTAGAACCATTAATGATGGTAATCATCGGCAGTCTGATTGGGATTATTATGATGGGAATGTATTTACCTATCTTTAAT
ATGGGATCAGTTATTCAATGA

Domains

Predicted by InterproScan.

Type II secretion system (T2SS), protein F (T2SSF)

(63-185)

Type II secretion system (T2SS), protein F (T2SSF)

(266-397)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q4QNP6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pilC Haemophilus influenzae 86-028NP

100

100

1
  pilC Haemophilus influenzae Rd KW20

97.783

100

0.978
  pilC Glaesserella parasuis strain SC1401

38.155

98.768

0.377

Multiple sequence alignment