Detailed information NTG0118058

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: STAB904_RS00325
• Genome accession: NZ_CP007241
• Coordinates: 52789..53700 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain 1E1
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 47789..58700

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STAB904_RS00305 (STAB904_00330)	purE	48375..48866 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
STAB904_RS00310 (STAB904_00335)	purK	48853..49926 (+)	1074	WP_038433065.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
STAB904_RS00315 (STAB904_00340)	-	49928..51346 (+)	1419	WP_011888524.1	hypothetical protein	-
STAB904_RS00320 (STAB904_00345)	purB	51366..52658 (+)	1293	WP_038433842.1	adenylosuccinate lyase	-
STAB904_RS00325 (STAB904_00350)	comR	52789..53700 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
STAB904_RS09625	comS	53784..53879 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
STAB904_RS00330 (STAB904_00360)	ruvB	53926..54924 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
STAB904_RS00335 (STAB904_00365)	-	55062..55499 (+)	438	WP_038433843.1	low molecular weight protein-tyrosine-phosphatase	-
STAB904_RS00340 (STAB904_00370)	-	55522..55923 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
STAB904_RS00345 (STAB904_00375)	-	55920..57695 (+)	1776	WP_023612103.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=118058 STAB904_RS00325 WP_002986681.1 52789..53700(+) (comR) [Streptococcus pyogenes strain 1E1]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=118058 STAB904_RS00325 WP_002986681.1 52789..53700(+) (comR) [Streptococcus pyogenes strain 1E1]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462