Detailed information NTG1170384

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ACLV7D_RS08160
• Genome accession: NZ_OZ217345
• Coordinates: 1701536..1702273 (-)
• Length: 245 a.a.
• NCBI ID: WP_173234442.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis F22
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1696536..1707273

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7D_RS08130 (SMIF22_16060)	blpZ	1696589..1696837 (-)	249	WP_218764780.1	immunity protein BlpZ	-
ACLV7D_RS08135 (SMIF22_16070)	-	1696879..1697568 (-)	690	WP_173219796.1	CPBP family intramembrane glutamic endopeptidase	-
ACLV7D_RS08140 (SMIF22_16080)	-	1697632..1698015 (-)	384	WP_173219793.1	immunity protein	-
ACLV7D_RS08145 (SMIF22_16090)	-	1698498..1698902 (-)	405	WP_138704684.1	immunity protein	-
ACLV7D_RS08150 (SMIF22_16110)	-	1699350..1699469 (-)	120	WP_173219790.1	PncF family bacteriocin immunity protein	-
ACLV7D_RS08155 (SMIF22_16130)	-	1700173..1701522 (-)	1350	WP_173234444.1	sensor histidine kinase	-
ACLV7D_RS08160 (SMIF22_16140)	comE/blpR	1701536..1702273 (-)	738	WP_173234442.1	response regulator transcription factor	Regulator
ACLV7D_RS08165 (SMIF22_16150)	-	1702569..1702898 (+)	330	WP_173234440.1	helicase BlpT	-
ACLV7D_RS08170 (SMIF22_16160)	pptB	1702960..1704009 (-)	1050	WP_173234438.1	ABC transporter permease	Regulator
ACLV7D_RS08175 (SMIF22_16170)	pptA	1704006..1704737 (-)	732	WP_173234436.1	ABC transporter ATP-binding protein	Regulator
ACLV7D_RS08180 (SMIF22_16180)	-	1704805..1705215 (+)	411	WP_050275810.1	HIT family protein	-
ACLV7D_RS08185 (SMIF22_16190)	-	1705225..1705512 (+)	288	WP_173234434.1	hypothetical protein	-
ACLV7D_RS08190 (SMIF22_16200)	dnaJ	1705907..1707046 (-)	1140	WP_173234432.1	molecular chaperone DnaJ	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28838.96 Da
• Isoelectric Point: 5.6619

>NTDB_id=1170384 ACLV7D_RS08160 WP_173234442.1 1701536..1702273(-) (comE/blpR) [Streptococcus mitis isolate S. mitis F22]
MRIFVLEDDFSQQTRIETTIEKLLQEHQIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDWD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVRLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=1170384 ACLV7D_RS08160 WP_173234442.1 1701536..1702273(-) (comE/blpR) [Streptococcus mitis isolate S. mitis F22]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGCAAGAACA
TCAGATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCAGACCAGCTGCTGGCAGAGGTGCATGAGAAGGGAGCCCATC
AACTATTCTTTTTGGACATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGATTGGGAT
CCTTATGCTCTCATCGTCTTTGTGACGACTCACTCAGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTCTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGTTTTTACTTTAAATCAAAATTTGCCCAATTCCAGTATCCTTTTAAAGAGGTTTATTAT
CTCGAAACATCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTGGAATTTACGGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCTCGTCTCTTGCAGTGCCACCGCTCATTTCTCATCAATCCTGCCAATGTGGTTCGTTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTATCTGAAGCT
ATCAATAACTTGCATTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-241)

• Response regulator receiver domain (Response_reg) (3-122)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.733	99.184	0.543
comE/comE1	Streptococcus equinus JB1	43.038	96.735	0.416
comE/comE2	Streptococcus equinus JB1	39.256	98.776	0.388