Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   ACLV7A_RS06615 Genome accession   NZ_OZ217344
Coordinates   1343942..1345276 (-) Length   444 a.a.
NCBI ID   WP_411863904.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis E22     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1338942..1350276
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7A_RS06600 (SMIE22_13010) - 1339909..1342359 (-) 2451 WP_411863901.1 bifunctional DnaQ family exonuclease/ATP-dependent helicase -
  ACLV7A_RS06605 (SMIE22_13020) - 1342557..1343486 (-) 930 WP_411863902.1 peptidase U32 family protein -
  ACLV7A_RS06610 (SMIE22_13030) - 1343626..1343913 (+) 288 WP_411863903.1 DUF3270 domain-containing protein -
  ACLV7A_RS06615 (SMIE22_13040) ciaH 1343942..1345276 (-) 1335 WP_411863904.1 two-component system sensor histidine kinase CiaH Regulator
  ACLV7A_RS06620 (SMIE22_13050) ciaR 1345266..1345940 (-) 675 WP_000590627.1 two-component system response regulator CiaR Regulator
  ACLV7A_RS06625 (SMIE22_13060) - 1346047..1348593 (-) 2547 WP_411863905.1 M1 family metallopeptidase -
  ACLV7A_RS06630 (SMIE22_13070) - 1348716..1349156 (-) 441 WP_411863906.1 ASCH domain-containing protein -
  ACLV7A_RS06635 (SMIE22_13080) - 1349098..1350000 (-) 903 WP_411863907.1 putative PEP-binding protein -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50728.48 Da        Isoelectric Point: 9.1616

>NTDB_id=1170296 ACLV7A_RS06615 WP_411863904.1 1343942..1345276(-) (ciaH) [Streptococcus mitis isolate S. mitis E22]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAVNRATEEIKDLENAT
TDTSKTEIKPNVSSNTEVILFDKNFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRMILMETNISSISTN
IKYAAVLINTSQLEQASQKHEKLIVIVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENDRVFRFENRI
HRPIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGVGISAEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTITVKDNKPKGTIFEVKIAIHTPSKKKK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=1170296 ACLV7A_RS06615 WP_411863904.1 1343942..1345276(-) (ciaH) [Streptococcus mitis isolate S. mitis E22]
ATGTTCAGTAAACTAAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTTGGTGTCTTTACCTTGAT
TTTCTCGACAATGACTCTGATTATTTTACAGGTCATGCATTCGAGTCTCTATACTTCGGTGGATGATAAGCTCCACGGAC
TAAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCAGTAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCCACT
ACAGATACTAGCAAGACTGAGATAAAACCCAATGTCAGTTCCAATACGGAAGTCATTCTCTTTGATAAGAACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGCCATATCTACCAGATTC
AGGTTTTTAATAGCTATGGACAAGAAGAAATCTATCGCATGATTTTGATGGAGACGAATATTAGTTCGATTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATAAATACCAGTCAGTTGGAGCAGGCCAGTCAAAAGCATGAGAAATTGATTGTGATTGT
GATGGCAAGTTTCTGGATTTTGTCTTTGCTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTCGTCCTTTACTTGAAAGTA
TGCAGAAGCAGCAGTCTTTTGTGGAAAATGCTAGTCATGAGTTACGGACTCCACTTGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTCCGTAAGCCAGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAACAT
GCGTTTTTTGACGACAAACTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCGGAGCTTGCAGAAGTTCCAACTA
GTTTTTTCAATACGACTTTCACAAACTATGAGATGATTGCTTCGGAAAATGATCGTGTCTTCCGTTTTGAAAATCGGATC
CATCGTCCGATTGTCACAGATCAGCTTCTCTTGAAGCAGTTAATGACTATCCTATTTGATAATGCTGTCAAGTATACTGA
AGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGTAATCTGTATTTACTGGTTTCTGATAATGGAGTCGGTA
TTTCCGCAGAAGATAAGAAGAAAATTTTTGACCGCTTTTATCGAGTTGATAAGGCTAGAACGCGCCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCTTTAAAAGGAACCATTACTGTCAAAGATAATAAACCCAAGGG
TACAATCTTTGAAGTGAAGATTGCCATCCACACACCGTCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

96.171

100

0.962
  ciaH Streptococcus pneumoniae D39

96.171

100

0.962
  ciaH Streptococcus pneumoniae R6

96.171

100

0.962
  ciaH Streptococcus pneumoniae TIGR4

96.171

100

0.962
  ciaH Streptococcus mutans UA159

55.632

97.973

0.545

Multiple sequence alignment