Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   ACLV7Z_RS07350 Genome accession   NZ_OZ217343
Coordinates   1441366..1442700 (-) Length   444 a.a.
NCBI ID   WP_218773872.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis G22     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1436366..1447700
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7Z_RS07335 (SMIG22_14380) - 1437330..1439780 (-) 2451 WP_218773874.1 bifunctional DnaQ family exonuclease/ATP-dependent helicase -
  ACLV7Z_RS07340 (SMIG22_14400) - 1439981..1440910 (-) 930 WP_172935138.1 peptidase U32 family protein -
  ACLV7Z_RS07345 (SMIG22_14410) - 1441050..1441337 (+) 288 WP_218773873.1 DUF3270 domain-containing protein -
  ACLV7Z_RS07350 (SMIG22_14420) ciaH 1441366..1442700 (-) 1335 WP_218773872.1 two-component system sensor histidine kinase CiaH Regulator
  ACLV7Z_RS07355 (SMIG22_14430) ciaR 1442690..1443364 (-) 675 WP_000590628.1 two-component system response regulator CiaR Regulator
  ACLV7Z_RS07360 (SMIG22_14440) - 1443471..1446017 (-) 2547 WP_218773871.1 M1 family metallopeptidase -
  ACLV7Z_RS07365 (SMIG22_14450) - 1446140..1446580 (-) 441 WP_218773870.1 ASCH domain-containing protein -
  ACLV7Z_RS07370 (SMIG22_14460) - 1446577..1447425 (-) 849 WP_218773869.1 putative PEP-binding protein -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50714.41 Da        Isoelectric Point: 8.8716

>NTDB_id=1170217 ACLV7Z_RS07350 WP_218773872.1 1441366..1442700(-) (ciaH) [Streptococcus mitis isolate S. mitis G22]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAVNRATEEIKDLENAA
TDTSKTEIKPNVSSNTEVILFDKNFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRMILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVIVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENDRVFRFENRI
HRPIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGVGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTITVKDNKPKGTIFEVKIAIHTPSKKKK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=1170217 ACLV7Z_RS07350 WP_218773872.1 1441366..1442700(-) (ciaH) [Streptococcus mitis isolate S. mitis G22]
ATGTTCAGTAAACTAAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTTGGTGTCTTTACCTTGAT
TTTCTCTACCATGACTCTGATTATTTTACAGGTCATGCATTCGAGTCTTTATACTTCGGTGGATGATAAGCTCCACGGAC
TGAGTGAAAATCCTCAGGCAGTTATTCAGCTGGCAGTAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCCGCT
ACAGATACTAGCAAGACTGAGATAAAACCCAATGTCAGTTCTAACACAGAAGTCATTCTCTTTGATAAGAACTTTACCCA
GCTCCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGCCATATCTACCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTATGATTTTGATGGAGACCAATATCAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATAAATACCAGTCAGTTAGAGCAGGCCAGTCAAAAGCATGAGCAATTGATTGTGATTGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTCGGCCCCTGCTTGAGAGCA
TGCAGAAGCAACAATCCTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTTGCAGTTCTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGTGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTGACGACAAACTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCGGAGCTTGCAGAAGTTCCAACTA
GTTTTTTCAATACGACTTTCACAAACTATGAGATGATTGCTTCGGAAAATGATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGTCCGATTGTGACGGATCAACTTCTCTTGAAGCAGTTGATGACGATTCTCTTCGATAATGCCGTCAAGTATACTGA
AGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTGTATTTACTGGTTTCTGATAATGGAGTCGGTA
TTTCCACGGAAGATAAGAAGAAAATTTTTGACCGTTTTTATCGAGTTGATAAGGCTAGAACCCGTCAAAAAGGTGGTTTT
GGTTTAGGTTTATCCCTAGCCAAGCAAATTGTAGATGCTCTAAAAGGAACCATTACTGTCAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATCCACACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

96.847

100

0.968
  ciaH Streptococcus pneumoniae D39

96.847

100

0.968
  ciaH Streptococcus pneumoniae R6

96.847

100

0.968
  ciaH Streptococcus pneumoniae TIGR4

96.847

100

0.968
  ciaH Streptococcus mutans UA159

55.632

97.973

0.545

Multiple sequence alignment