Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   ACLV7Q_RS07010 Genome accession   NZ_OZ217341
Coordinates   1421446..1422780 (-) Length   444 a.a.
NCBI ID   WP_218757630.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis C22     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1416446..1427780
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7Q_RS06995 (SMIC22_13730) - 1417411..1419861 (-) 2451 WP_218757628.1 bifunctional DnaQ family exonuclease/ATP-dependent helicase -
  ACLV7Q_RS07000 (SMIC22_13740) - 1420061..1420990 (-) 930 WP_218757629.1 peptidase U32 family protein -
  ACLV7Q_RS07005 (SMIC22_13750) - 1421130..1421417 (+) 288 WP_112443507.1 DUF3270 domain-containing protein -
  ACLV7Q_RS07010 (SMIC22_13760) ciaH 1421446..1422780 (-) 1335 WP_218757630.1 two-component system sensor histidine kinase CiaH Regulator
  ACLV7Q_RS07015 (SMIC22_13770) ciaR 1422770..1423444 (-) 675 WP_000590628.1 two-component system response regulator CiaR Regulator
  ACLV7Q_RS07020 (SMIC22_13780) - 1423552..1426098 (-) 2547 WP_218757631.1 M1 family metallopeptidase -
  ACLV7Q_RS07025 (SMIC22_13790) - 1426221..1426661 (-) 441 WP_218757632.1 ASCH domain-containing protein -
  ACLV7Q_RS07030 (SMIC22_13800) - 1426621..1427506 (-) 886 Protein_1336 putative PEP-binding protein -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50686.36 Da        Isoelectric Point: 8.8716

>NTDB_id=1170050 ACLV7Q_RS07010 WP_218757630.1 1421446..1422780(-) (ciaH) [Streptococcus mitis isolate S. mitis C22]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAVNRATEEIKDLENAA
TDSSKTEVKPNVSSNTEVILFDKNFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRMILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVIVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENDRVFRFENRI
HRPIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGVGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTITVKDNKPKGTIFEVKIAIHTPSKKKK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=1170050 ACLV7Q_RS07010 WP_218757630.1 1421446..1422780(-) (ciaH) [Streptococcus mitis isolate S. mitis C22]
ATGTTCAGTAAACTAAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTTGGTGTCTTCACTCTGAT
TTTCTCCACCATGACCTTGATTATTTTACAAGTCATGCATTCGAGTCTCTATACTTCGGTGGATGATAAGCTCCACGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCAGTAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCCGCT
ACAGATTCTAGCAAGACTGAGGTGAAACCCAATGTCAGCTCCAATACGGAGGTTATTCTTTTTGATAAGAATTTTACCCA
GCTCCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTATCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTATGATATTGATGGAAACCAATATCAGTTCGGTTTCAACCAAT
ATCAAGTATGCCGCTGTCTTGATAAATACCAGTCAGTTAGAGCAGGCCAGTCAAAAGCATGAGCAATTGATTGTGATTGT
GATGGCAAGTTTCTGGATTTTGTCTTTGCTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTCGGCCTTTACTTGAAAGTA
TGCAGAAGCAGCAGTCTTTTGTGGAAAATGCTAGTCATGAGTTACGGACTCCACTTGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTCCGTAAGCCAGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTGACGACAAACTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCGGAGCTTGCAGAAGTTCCAACTA
GTTTTTTCAATACGACTTTTACAAACTATGAGATGATTGCTTCGGAAAATGATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGTCCGATTGTGACGGATCAGCTTCTCTTGAAGCAGTTGATGACGATTCTCTTCGATAATGCTGTCAAGTATACTGA
GGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACAGATCGCAATCTGTATTTACTTGTTTCTGATAATGGAGTCGGTA
TTTCCACAGAAGATAAGAAGAAAATTTTTGACCGCTTTTATCGAGTGGACAAGGCTAGAACCCGTCAAAAAGGTGGTTTT
GGTTTAGGATTATCTCTGGCCAAGCAAATTGTAGATGCGCTAAAAGGAACCATTACTGTCAAAGATAATAAACCAAAAGG
AACAATCTTTGAAGTGAAGATTGCCATTCATACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

96.622

100

0.966
  ciaH Streptococcus pneumoniae D39

96.622

100

0.966
  ciaH Streptococcus pneumoniae R6

96.622

100

0.966
  ciaH Streptococcus pneumoniae TIGR4

96.622

100

0.966
  ciaH Streptococcus mutans UA159

55.53

97.748

0.543

Multiple sequence alignment