Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   ACLV7H_RS01925 Genome accession   NZ_OZ217340
Coordinates   366853..367590 (+) Length   245 a.a.
NCBI ID   WP_045591846.1    Uniprot ID   A0A0F2CZ05
Organism   Streptococcus oralis isolate S. oralis A22     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 361853..372590
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7H_RS01890 (SORA22_03730) - 362577..363236 (-) 660 WP_411866214.1 hypothetical protein -
  ACLV7H_RS01895 (SORA22_03740) - 363299..363577 (-) 279 WP_411866215.1 hypothetical protein -
  ACLV7H_RS01900 (SORA22_03750) - 363587..363997 (-) 411 WP_411866216.1 HIT family protein -
  ACLV7H_RS01905 (SORA22_03760) pptA 364065..364796 (+) 732 WP_411866217.1 ABC transporter ATP-binding protein Regulator
  ACLV7H_RS01910 (SORA22_03770) - 364793..365842 (+) 1050 WP_411866218.1 ABC transporter permease -
  ACLV7H_RS01915 (SORA22_03780) - 365902..366231 (-) 330 WP_411866219.1 helicase BlpT -
  ACLV7H_RS01920 (SORA22_03790) - 366510..366848 (+) 339 WP_001106571.1 LytTR family DNA-binding domain-containing protein -
  ACLV7H_RS01925 (SORA22_03800) comE/blpR 366853..367590 (+) 738 WP_045591846.1 response regulator transcription factor Regulator
  ACLV7H_RS01930 (SORA22_03810) - 367604..368944 (+) 1341 WP_411866220.1 sensor histidine kinase -
  ACLV7H_RS01935 (SORA22_03820) blpC 368987..369142 (-) 156 WP_000360258.1 quorum-sensing system pheromone BlpC -
  ACLV7H_RS01940 (SORA22_03830) - 369199..370560 (-) 1362 WP_268719322.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28774.94 Da        Isoelectric Point: 5.8765

>NTDB_id=1169946 ACLV7H_RS01925 WP_045591846.1 366853..367590(+) (comE/blpR) [Streptococcus oralis isolate S. oralis A22]
MRIFVLEDDFSQQARIETTIEKLLKEQHIIPSSFEVFGKPDQLLAEMHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKSLSAEEFESRIETALLYADSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVLKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=1169946 ACLV7H_RS01925 WP_045591846.1 366853..367590(+) (comE/blpR) [Streptococcus oralis isolate S. oralis A22]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAAGCTAGGATTGAAACGACGATTGAGAAACTTCTGAAAGAACA
GCATATCATTCCCAGCTCTTTTGAAGTTTTTGGCAAGCCAGACCAACTTCTGGCAGAGATGCATGAGAAGGGAGCACATC
AGCTATTCTTTTTGGACATTGAGATTCGAAATGAGGAGATGAAAGGCCTAGAAGTGGCAAGAAAGATTCGGGATCGAGAT
CCTTATGCCCTGATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGTCCTTGTCGGCAGAGGAGTTTGAGTCTCGTATCGAGACAGCTCTTCTCTATGCCGATAGTCAAGACA
GTAAAAGCCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCTCAATTCCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCTCCTAGAGCCCATCGTGTTATTCTCTATACCAAGACGGATAGACTGGAATTTACGGCGAGCCTAGAGGA
GGTTCTCAAGCAGGAGCCTCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCGCGTTATAAGGTTAGGGAAGTTTCTGAGGCT
ATCAATAATTTGCATTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0F2CZ05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.132

98.776

0.535
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.43

98.776

0.38
  comE Streptococcus infantis strain Atu-4

36.179

100

0.363

Multiple sequence alignment