Detailed information    

insolico Bioinformatically predicted

Overview

Name   comFA/cflA   Type   Machinery gene
Locus tag   U8955_RS09985 Genome accession   NZ_OY769914
Coordinates   1988839..1990137 (-) Length   432 a.a.
NCBI ID   WP_038804759.1    Uniprot ID   A0A7T2ZXU6
Organism   Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1983839..1995137
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U8955_RS09965 (SDENT7746_10015) - 1984154..1986127 (-) 1974 WP_038804756.1 DHH family phosphoesterase -
  U8955_RS09970 (SDENT7746_10020) - 1986286..1987464 (-) 1179 WP_038804814.1 acetyl-CoA C-acetyltransferase -
  U8955_RS09975 (SDENT7746_10025) hpf 1987552..1988100 (-) 549 WP_000599119.1 ribosome hibernation-promoting factor, HPF/YfiA family -
  U8955_RS09980 (SDENT7746_10030) comFC/cflB 1988180..1988842 (-) 663 WP_038804758.1 ComF family protein Machinery gene
  U8955_RS09985 (SDENT7746_10035) comFA/cflA 1988839..1990137 (-) 1299 WP_038804759.1 DEAD/DEAH box helicase Machinery gene
  U8955_RS09990 (SDENT7746_10040) - 1990194..1990829 (+) 636 WP_038804761.1 YigZ family protein -
  U8955_RS09995 (SDENT7746_10045) cysK 1990985..1991911 (+) 927 WP_038804762.1 cysteine synthase A -
  U8955_RS10000 (SDENT7746_10055) tsf 1992026..1993066 (-) 1041 WP_000808060.1 translation elongation factor Ts -
  U8955_RS10005 (SDENT7746_10060) rpsB 1993146..1993925 (-) 780 WP_000268473.1 30S ribosomal protein S2 -

Sequence

Protein


Download         Length: 432 a.a.        Molecular weight: 49714.05 Da        Isoelectric Point: 9.5840

>NTDB_id=1161755 U8955_RS09985 WP_038804759.1 1988839..1990137(-) (comFA/cflA) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
MKVNPNYLGRLFTERELTKEERQMAVKLPAMRKEKGKLFCQRCNSSILEEWCLPIGAYYCRECLLMKRVRSDQALYYFPQ
EDFPKQDVLKWRGQLTPFQEKVSEGLIRAFKKKEPTLVHAVTGAGKTEMIYQVVAKVIDNGGSVCLASPRIDVCLELYKR
LQNDFACEIALLHGESEPYFRTPLVVATTHQLLKFYHAFDLLIVDEVDAFPYVDNPILYYAVNQCVKKDGLRIFLTATST
DELDKKVRTGKLKRLSLPRRFHGNPLIIPKPVWLSDFNRYLDKSQLSPKLKISIQKQRRTGYRLLIFASEIKKGEKLKEI
LQVYFPDEKIGFVSSVTEDRLEQVQAFRDGELTILISTTILERGVTFPCVDVFVVEANHRLFTKSSLIQIGGRVGRSMDR
PTGELLFFHDGLNTSIKKAIKEIKQMNKEAGL

Nucleotide


Download         Length: 1299 bp        

>NTDB_id=1161755 U8955_RS09985 WP_038804759.1 1988839..1990137(-) (comFA/cflA) [Streptococcus oralis subsp. dentisani isolate Streptococcus dentisani 7746]
ATGAAAGTAAATCCAAATTATCTCGGTCGCTTGTTTACTGAGAGAGAATTAACTAAAGAAGAACGTCAAATGGCCGTGAA
ACTACCAGCAATGAGAAAAGAGAAGGGAAAACTTTTCTGTCAACGGTGTAATAGTAGCATTCTAGAAGAATGGTGTTTGC
CCATTGGTGCTTACTATTGTAGGGAGTGTTTATTGATGAAGCGAGTCAGGAGTGATCAAGCTTTATACTATTTTCCGCAG
GAAGATTTTCCTAAGCAAGATGTTCTCAAATGGCGTGGCCAGCTAACCCCTTTTCAGGAGAAGGTGTCAGAAGGATTGAT
TCGAGCATTTAAAAAGAAGGAACCGACTTTAGTTCATGCTGTGACAGGTGCTGGAAAAACAGAGATGATTTATCAAGTTG
TAGCCAAAGTGATTGACAATGGTGGTTCAGTTTGTTTGGCAAGTCCTCGCATAGACGTGTGTTTGGAACTGTATAAGCGA
CTGCAGAATGACTTTGCTTGTGAGATAGCACTACTTCATGGCGAATCAGAGCCCTATTTTCGAACTCCCCTAGTGGTTGC
AACGACGCATCAGTTATTAAAATTCTATCATGCCTTTGATTTGTTGATAGTAGATGAAGTAGATGCCTTTCCTTATGTTG
ACAACCCTATACTTTACTATGCTGTAAACCAATGTGTAAAGAAAGATGGGTTAAGGATATTCCTTACAGCAACTTCTACA
GATGAGTTAGATAAGAAGGTTCGCACAGGAAAATTAAAAAGGTTGAGCTTGCCAAGACGATTTCATGGAAATCCATTGAT
TATTCCAAAGCCAGTTTGGTTATCGGATTTTAATCGTTATTTAGATAAGAGTCAGTTGTCACCAAAGTTAAAGATCTCTA
TTCAGAAGCAGAGAAGAACAGGTTATCGCTTGTTAATCTTTGCATCAGAAATTAAAAAAGGCGAGAAACTAAAAGAAATC
TTGCAGGTGTATTTTCCAGATGAGAAAATTGGTTTTGTGTCTTCTGTGACAGAAGACCGATTAGAGCAGGTGCAAGCTTT
TCGAGATGGAGAACTAACAATACTGATCAGTACGACAATATTGGAACGCGGAGTTACCTTCCCTTGTGTGGATGTTTTCG
TAGTAGAAGCTAATCATCGTCTCTTTACCAAGTCTAGCTTGATTCAGATTGGTGGGCGAGTTGGGCGTAGTATGGACAGA
CCAACTGGTGAGTTGCTCTTCTTTCATGATGGATTAAATACTTCCATCAAAAAGGCAATCAAGGAAATCAAGCAGATGAA
CAAGGAGGCGGGATTATGA

Domains

Predicted by InterproScan.

Type III restriction enzyme, res subunit (ResIII)

(94-168)

Helicase conserved C-terminal domain (Helicase_C)

(294-396)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7T2ZXU6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comFA/cflA Streptococcus mitis SK321

89.12

100

0.891
  comFA/cflA Streptococcus mitis NCTC 12261

88.426

100

0.884
  comFA/cflA Streptococcus pneumoniae Rx1

88.194

100

0.882
  comFA/cflA Streptococcus pneumoniae D39

88.194

100

0.882
  comFA/cflA Streptococcus pneumoniae R6

88.194

100

0.882
  comFA/cflA Streptococcus pneumoniae TIGR4

87.963

100

0.88
  comFA Lactococcus lactis subsp. cremoris KW2

50.367

94.676

0.477
  comFA Latilactobacillus sakei subsp. sakei 23K

38.979

99.769

0.389

Multiple sequence alignment