Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEC/celB   Type   Machinery gene
Locus tag   QOR45_RS06405 Genome accession   NZ_OX460935
Coordinates   1252031..1254268 (-) Length   745 a.a.
NCBI ID   WP_283572172.1    Uniprot ID   -
Organism   Streptococcus agalactiae isolate MRI Z2-286     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1241385..1312117 1252031..1254268 within 0
IS/Tn 1254969..1256432 1252031..1254268 flank 701


Gene organization within MGE regions


Location: 1241385..1312117
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QOR45_RS06360 - 1242625..1244493 (-) 1869 WP_283572167.1 PTS beta-glucoside transporter subunit IIBCA -
  QOR45_RS06365 - 1244486..1244749 (-) 264 Protein_1179 PRD domain-containing protein -
  QOR45_RS06370 - 1244825..1245969 (+) 1145 WP_088881664.1 IS3 family transposase -
  QOR45_RS06375 sodA 1246407..1247015 (-) 609 WP_000974717.1 superoxide dismutase SodA -
  QOR45_RS06380 holA 1247074..1248132 (-) 1059 WP_283572168.1 DNA polymerase III subunit delta -
  QOR45_RS06385 - 1248180..1248914 (-) 735 WP_283572169.1 methyltransferase domain-containing protein -
  QOR45_RS06390 - 1249090..1250082 (+) 993 WP_283572170.1 alpha/beta hydrolase -
  QOR45_RS06395 - 1250141..1251085 (-) 945 WP_283572171.1 LacI family DNA-binding transcriptional regulator -
  QOR45_RS06400 - 1251096..1251905 (-) 810 WP_115341449.1 Cof-type HAD-IIB family hydrolase -
  QOR45_RS06405 comEC/celB 1252031..1254268 (-) 2238 WP_283572172.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  QOR45_RS06410 - 1254252..1254906 (-) 655 Protein_1188 helix-hairpin-helix domain-containing protein -
  QOR45_RS06415 - 1254969..1256432 (-) 1464 WP_283572173.1 IS1182-like element IS1563 family transposase -
  QOR45_RS06420 - 1256567..1257307 (-) 741 WP_000500220.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
  QOR45_RS06425 - 1257442..1258206 (+) 765 WP_000611116.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  QOR45_RS06430 - 1258199..1258465 (+) 267 WP_000598734.1 GIY-YIG nuclease family protein -
  QOR45_RS06435 - 1258647..1260233 (-) 1587 WP_000673086.1 DEAD/DEAH box helicase -
  QOR45_RS06440 - 1260467..1261297 (-) 831 WP_000735511.1 MetQ/NlpA family ABC transporter substrate-binding protein -
  QOR45_RS06445 - 1261313..1261975 (-) 663 WP_000565395.1 methionine ABC transporter permease -
  QOR45_RS06450 - 1261968..1262702 (-) 735 WP_000582850.1 ATP-binding cassette domain-containing protein -
  QOR45_RS06455 - 1262895..1263275 (-) 381 WP_000510899.1 PH domain-containing protein -
  QOR45_RS06460 - 1263361..1264905 (-) 1545 WP_000174824.1 peptide chain release factor 3 -
  QOR45_RS06465 - 1265082..1266620 (-) 1539 WP_001043081.1 LPXTG cell wall anchor domain-containing protein -
  QOR45_RS06470 - 1266799..1267485 (-) 687 WP_000569013.1 YwaF family protein -
  QOR45_RS06475 - 1267614..1268834 (-) 1221 WP_000793490.1 OFA family MFS transporter -
  QOR45_RS06480 murF 1269021..1270388 (-) 1368 WP_000777512.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
  QOR45_RS06485 - 1270535..1271581 (-) 1047 WP_000032510.1 D-alanine--D-alanine ligase -
  QOR45_RS06490 recR 1271722..1272318 (-) 597 WP_000966735.1 recombination mediator RecR -
  QOR45_RS06495 pbp2b 1272333..1274378 (-) 2046 WP_283572174.1 penicillin-binding protein PBP2B -
  QOR45_RS06500 - 1274507..1275199 (-) 693 WP_000240135.1 phosphoglycerate mutase -
  QOR45_RS06505 tpiA 1275376..1276134 (-) 759 WP_000087883.1 triose-phosphate isomerase -
  QOR45_RS06510 tuf 1276315..1277511 (-) 1197 WP_001040730.1 elongation factor Tu -
  QOR45_RS06515 - 1277863..1279131 (-) 1269 WP_047209425.1 FtsW/RodA/SpoVE family cell cycle protein -
  QOR45_RS06520 ppc 1279237..1282032 (-) 2796 WP_283572175.1 phosphoenolpyruvate carboxylase -
  QOR45_RS06525 pepF 1282241..1284040 (+) 1800 WP_283572176.1 oligoendopeptidase F -
  QOR45_RS06530 - 1284099..1284488 (-) 390 WP_000759944.1 DUF4430 domain-containing protein -
  QOR45_RS06535 - 1284472..1284996 (-) 525 WP_000594806.1 ECF transporter S component -
  QOR45_RS06540 - 1285153..1286001 (+) 849 WP_001254338.1 glycoside hydrolase family 25 protein -
  QOR45_RS06545 - 1286011..1287465 (-) 1455 WP_115343210.1 IS1182-like element IS1563 family transposase -
  QOR45_RS06550 - 1287596..1288213 (-) 618 WP_000404301.1 NAD(P)H-binding protein -
  QOR45_RS06555 - 1288508..1288981 (+) 474 WP_000038840.1 aminoacyl-tRNA deacylase -
  QOR45_RS06560 - 1289003..1289644 (+) 642 WP_000675284.1 histidine phosphatase family protein -
  QOR45_RS06565 - 1289680..1290582 (-) 903 WP_000633102.1 HAD family hydrolase -
  QOR45_RS06570 lysS 1290757..1292247 (+) 1491 WP_000070710.1 lysine--tRNA ligase -
  QOR45_RS06575 - 1292474..1294162 (-) 1689 WP_283572177.1 hypothetical protein -
  QOR45_RS06580 - 1294182..1295326 (+) 1145 WP_088881664.1 IS3 family transposase -
  QOR45_RS06585 - 1295344..1296273 (-) 930 WP_283572178.1 DEAD/DEAH box helicase family protein -
  QOR45_RS06590 - 1296273..1298108 (-) 1836 WP_283572179.1 site-specific DNA-methyltransferase -
  QOR45_RS06595 - 1298336..1299511 (+) 1176 WP_000191687.1 IS256-like element ISSag11 family transposase -
  QOR45_RS06600 - 1299545..1299823 (-) 279 WP_283572292.1 DUF5960 family protein -
  QOR45_RS06605 - 1299798..1300175 (-) 378 WP_111715815.1 hypothetical protein -
  QOR45_RS06610 - 1300172..1301587 (-) 1416 WP_283572180.1 Y-family DNA polymerase -
  QOR45_RS06615 - 1301590..1302267 (-) 678 WP_039670447.1 LexA family transcriptional regulator -
  QOR45_RS06620 - 1302270..1303133 (-) 864 WP_283572181.1 ImmA/IrrE family metallo-endopeptidase -
  QOR45_RS06625 - 1303325..1303687 (+) 363 WP_283572182.1 hypothetical protein -
  QOR45_RS06630 - 1303736..1304077 (-) 342 WP_099412435.1 RstR family transcriptional repressor -
  QOR45_RS06635 - 1304680..1304928 (+) 249 WP_111715803.1 hypothetical protein -
  QOR45_RS06640 - 1304966..1305262 (+) 297 WP_111715801.1 cytoplasmic protein -
  QOR45_RS06645 - 1305281..1305736 (+) 456 WP_101750359.1 conjugal transfer protein -
  QOR45_RS06650 - 1305752..1307446 (+) 1695 WP_283572183.1 FtsK/SpoIIIE domain-containing protein -
  QOR45_RS06655 - 1307655..1308914 (+) 1260 WP_283572184.1 replication initiation factor domain-containing protein -
  QOR45_RS06660 - 1308898..1309128 (+) 231 WP_017649868.1 hypothetical protein -
  QOR45_RS06665 - 1309149..1309700 (+) 552 WP_099412092.1 conjugal transfer protein -
  QOR45_RS06670 - 1309713..1310693 (+) 981 WP_283572185.1 conjugal transfer protein -
  QOR45_RS06675 - 1310699..1310923 (+) 225 WP_111715789.1 hypothetical protein -
  QOR45_RS06680 - 1310925..1311347 (+) 423 WP_111715787.1 conjugal transfer protein -

Sequence

Protein


Download         Length: 745 a.a.        Molecular weight: 85455.34 Da        Isoelectric Point: 9.7374

>NTDB_id=1158992 QOR45_RS06405 WP_283572172.1 1252031..1254268(-) (comEC/celB) [Streptococcus agalactiae isolate MRI Z2-286]
MLQLTKYFPLKPIYLALLVFQIYLLVFSWTMLGCAFLLFTFIFLIYQYDRETIFKTIAIVIFFLFYFLWQNHNMNVQYQR
VPNHISQIEVRIDTISINGDVLSFQADASGNTYQAFYTLKNKSEKDYFQNLDNNIMIIADIKLEEAEERRHFNGFDYRQY
LKRHGIYRIAKVTKIKQIRLSQHRSFFALMSKWRRSAIVISQTFPNPMRHYMSGLLFGYLDKTFDDMSDLYSSLGIIHLF
ALSGMQVGFFLGIFRYICLRIGLRLDHVWLLQIPFSLIYAGLTGFSISVVRALIQSLLSHSGVKKDENFALCLLICLISL
PHSLLTTGGVLSFAYAFILTMTSFDHFSSIKKLAIESLTVSVGILPILTYYFSGFQPISIILTALLSFAFDIIFLPLLTV
IFVLSPIVKLSCINSLFEILEVLLKWTGQLFPRPLIFGKPSLFLLIVMIIILGLLYDYYHSKCFRYCSLLIIFTLFFITK
NPITNEVAILDVGQGDSILVRDWLGKTILIDTGGRVRFEQPEEWKQKVNQSNAERTLIPYLKSRGISKIDDLVITHTDTD
HMGDMEVISKHFKVARLITSSGSLTNLQYVKRLSKIGVAVKSIEAGDKLAVMGSYLQVLYPWHKGDGKNNDSIVLYGHLL
GKGFLFTGDLEEEGEKQLLEAYPNLSVDILKAGHHGSKGSSSLSFLKKLSPSVVLVSAGKNNRYQHPHQETLQRFQKIKS
KIFRTDQSGTIRLTGWWKWHIQTVR

Nucleotide


Download         Length: 2238 bp        

>NTDB_id=1158992 QOR45_RS06405 WP_283572172.1 1252031..1254268(-) (comEC/celB) [Streptococcus agalactiae isolate MRI Z2-286]
ATGTTACAATTGACTAAGTATTTTCCTCTAAAACCTATTTATTTAGCATTGTTGGTCTTCCAAATTTACTTACTAGTGTT
TTCTTGGACAATGCTTGGTTGTGCCTTTCTTTTATTTACTTTTATTTTTCTGATTTATCAATATGATCGTGAAACTATTT
TTAAAACAATAGCAATAGTAATTTTTTTCTTATTTTATTTTTTATGGCAAAATCACAATATGAATGTCCAATATCAAAGA
GTACCGAATCATATTAGCCAGATTGAAGTGCGTATTGATACTATTTCTATCAATGGTGATGTTTTATCATTCCAGGCAGA
TGCTTCAGGTAACACTTATCAAGCTTTTTACACATTAAAAAATAAAAGTGAGAAAGATTATTTTCAAAATCTTGATAATA
ATATAATGATCATTGCAGATATCAAACTCGAAGAAGCAGAGGAGAGAAGGCATTTTAATGGCTTTGATTATCGTCAGTAT
TTAAAAAGACATGGAATTTATCGTATCGCCAAAGTGACAAAGATAAAACAGATACGCTTATCTCAACATAGGTCTTTCTT
TGCTCTTATGTCTAAGTGGCGTAGAAGTGCAATTGTTATTAGTCAAACTTTTCCAAATCCTATGCGTCACTATATGTCAG
GGCTTTTGTTTGGATATCTAGATAAGACCTTTGATGACATGTCCGATTTATATAGTAGTCTAGGTATTATACATTTATTT
GCTTTGTCAGGTATGCAAGTAGGTTTTTTTCTCGGTATTTTTCGTTATATCTGTCTACGTATTGGCTTACGCCTAGACCA
TGTTTGGTTACTTCAAATACCATTCTCGCTAATTTATGCTGGTTTAACAGGCTTTAGTATCTCAGTTGTTAGGGCACTTA
TTCAATCTTTATTATCACATAGCGGTGTCAAGAAAGATGAGAACTTTGCTCTCTGCTTGTTAATTTGTCTTATCTCTCTC
CCCCACTCACTTTTGACTACGGGAGGAGTTCTTAGCTTTGCTTATGCTTTTATACTTACGATGACCTCCTTTGATCATTT
TTCGAGTATAAAAAAACTAGCTATCGAATCTTTGACAGTCTCTGTAGGAATTCTTCCCATACTAACCTACTATTTTTCAG
GTTTTCAACCAATATCAATTATATTAACAGCACTTTTATCTTTTGCATTTGATATTATATTTTTGCCTTTATTAACTGTT
ATATTTGTCTTATCGCCTATCGTTAAATTAAGTTGTATTAATAGTTTGTTTGAAATCCTAGAAGTGTTATTAAAATGGAC
TGGGCAACTGTTTCCAAGGCCACTTATTTTTGGAAAGCCCAGCCTTTTTCTTTTAATAGTCATGATTATAATTTTGGGAT
TACTTTATGATTATTATCATTCTAAATGTTTTCGTTATTGCTCCCTTCTTATTATCTTTACCTTGTTTTTTATCACTAAG
AATCCAATTACTAACGAGGTTGCGATTTTAGATGTTGGACAGGGAGATAGTATTTTAGTGAGGGATTGGTTAGGAAAAAC
AATTTTAATTGATACTGGGGGAAGGGTGAGATTTGAACAGCCTGAAGAATGGAAACAAAAAGTAAATCAGTCTAATGCTG
AGAGAACGCTCATTCCTTACTTGAAAAGCAGAGGTATTAGCAAGATAGATGATTTAGTGATAACTCATACCGATACAGAT
CATATGGGGGATATGGAAGTTATCTCAAAGCATTTTAAAGTTGCACGTTTGATTACAAGTTCAGGTTCTTTAACGAATTT
GCAGTACGTTAAGCGTTTATCAAAGATAGGTGTAGCGGTAAAATCTATAGAAGCCGGTGATAAACTTGCTGTCATGGGAA
GTTATTTACAAGTACTTTACCCATGGCACAAGGGTGATGGAAAAAATAATGATTCAATTGTTTTATATGGACATTTATTA
GGAAAAGGCTTCTTATTTACTGGTGATTTGGAGGAAGAGGGAGAAAAGCAGTTATTAGAAGCTTATCCTAATTTATCAGT
AGATATCCTTAAAGCAGGACATCATGGTTCTAAGGGCTCATCAAGTCTATCTTTTCTGAAAAAGTTGTCTCCTAGTGTGG
TTCTAGTGTCAGCTGGTAAAAATAATCGTTACCAGCATCCTCATCAAGAGACTTTACAAAGGTTCCAAAAGATTAAAAGC
AAGATTTTCCGAACGGATCAATCAGGTACAATTAGGCTAACAGGATGGTGGAAGTGGCATATTCAGACAGTTCGTTGA

Domains

Predicted by InterproScan.

Competence protein (Competence)

(215-458)

Domain of unknown function (DUF4131) (DUF4131)

(28-177)

Metallo-beta-lactamase superfamily (Lactamase_B)

(491-694)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEC/celB Streptococcus mitis NCTC 12261

48.267

100

0.486
  comEC/celB Streptococcus mitis SK321

48.396

100

0.486
  comEC/celB Streptococcus pneumoniae TIGR4

46.925

100

0.471
  comEC/celB Streptococcus pneumoniae Rx1

46.452

100

0.466
  comEC/celB Streptococcus pneumoniae D39

46.452

100

0.466
  comEC/celB Streptococcus pneumoniae R6

46.452

100

0.466
  comEC Lactococcus lactis subsp. cremoris KW2

43.742

99.732

0.436

Multiple sequence alignment