Detailed information
Bioinformatically predicted
Overview
| Name | covR | Type | Regulator |
| Locus tag | SMUFR_RS08840 | Genome accession | NZ_CP007016 |
| Coordinates | 1802170..1802862 (-) | Length | 230 a.a. |
| NCBI ID | WP_002262121.1 | Uniprot ID | - |
| Organism | Streptococcus mutans UA159-FR | ||
| Function | repress comR expression (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1739975..1819367 | 1802170..1802862 | within | 0 |
Gene organization within MGE regions
Location: 1739975..1819367
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SMUFR_RS08520 (SMUFR_1605) | - | 1740106..1741545 (+) | 1440 | WP_002262658.1 | sucrose-6-phosphate hydrolase | - |
| SMUFR_RS08525 (SMUFR_1606) | - | 1741548..1742510 (+) | 963 | WP_002262659.1 | LacI family DNA-binding transcriptional regulator | - |
| SMUFR_RS08530 (SMUFR_1607) | nusB | 1742704..1743132 (-) | 429 | WP_002262660.1 | transcription antitermination factor NusB | - |
| SMUFR_RS08535 (SMUFR_1608) | - | 1743125..1743514 (-) | 390 | WP_002262661.1 | Asp23/Gls24 family envelope stress response protein | - |
| SMUFR_RS08540 (SMUFR_1609) | efp | 1743557..1744117 (-) | 561 | WP_002262662.1 | elongation factor P | - |
| SMUFR_RS08545 (SMUFR_1610) | - | 1744257..1744961 (+) | 705 | WP_002262663.1 | ion transporter | - |
| SMUFR_RS08550 (SMUFR_1611) | - | 1745009..1745461 (-) | 453 | WP_002262664.1 | deoxycytidylate deaminase | - |
| SMUFR_RS08555 (SMUFR_1612) | - | 1745631..1746695 (-) | 1065 | WP_002262665.1 | M24 family metallopeptidase | - |
| SMUFR_RS08560 (SMUFR_1613) | uvrA | 1746685..1749516 (-) | 2832 | WP_002262666.1 | excinuclease ABC subunit UvrA | - |
| SMUFR_RS08565 | - | 1749566..1749787 (+) | 222 | WP_019313410.1 | hypothetical protein | - |
| SMUFR_RS08570 (SMUFR_1614) | - | 1750187..1751131 (+) | 945 | WP_002262667.1 | magnesium transporter CorA family protein | - |
| SMUFR_RS08575 (SMUFR_1615) | - | 1751413..1752075 (+) | 663 | WP_002262668.1 | DUF1129 domain-containing protein | - |
| SMUFR_RS08580 (SMUFR_1616) | hdrR | 1752214..1752570 (+) | 357 | WP_002262669.1 | LytTR family transcriptional regulator HdrR | Regulator |
| SMUFR_RS08585 (SMUFR_1617) | hdrM | 1752567..1753253 (+) | 687 | WP_002262670.1 | hdrR negative regulator HdrM | Regulator |
| SMUFR_RS08590 (SMUFR_1618) | - | 1753261..1753980 (-) | 720 | WP_002262671.1 | TraX family protein | - |
| SMUFR_RS08595 (SMUFR_1619) | rpsR | 1754299..1754538 (-) | 240 | WP_000068664.1 | 30S ribosomal protein S18 | - |
| SMUFR_RS08600 (SMUFR_1620) | ssbA | 1754567..1755061 (-) | 495 | WP_002261867.1 | single-stranded DNA-binding protein | Machinery gene |
| SMUFR_RS08605 (SMUFR_1621) | rpsF | 1755079..1755369 (-) | 291 | WP_002261866.1 | 30S ribosomal protein S6 | - |
| SMUFR_RS08610 (SMUFR_1622) | - | 1755525..1755770 (-) | 246 | WP_002263367.1 | hypothetical protein | - |
| SMUFR_RS08615 | - | 1756075..1756278 (+) | 204 | WP_002263366.1 | hypothetical protein | - |
| SMUFR_RS08620 (SMUFR_1623) | mutY | 1757315..1758460 (+) | 1146 | WP_002263365.1 | A/G-specific adenine glycosylase | - |
| SMUFR_RS08625 (SMUFR_1624) | - | 1758648..1759697 (-) | 1050 | WP_002263364.1 | zinc-dependent alcohol dehydrogenase family protein | - |
| SMUFR_RS08630 (SMUFR_1625) | trxA | 1759795..1760109 (-) | 315 | WP_002263363.1 | thioredoxin | - |
| SMUFR_RS08635 (SMUFR_1626) | - | 1760184..1762514 (-) | 2331 | WP_002263362.1 | endonuclease MutS2 | - |
| SMUFR_RS08640 (SMUFR_1627) | - | 1762583..1763128 (-) | 546 | WP_002263361.1 | CvpA family protein | - |
| SMUFR_RS08645 (SMUFR_1628) | - | 1763125..1763430 (-) | 306 | WP_002263360.1 | hypothetical protein | - |
| SMUFR_RS08650 (SMUFR_1629) | rnhC | 1763626..1764537 (+) | 912 | WP_002271343.1 | ribonuclease HIII | - |
| SMUFR_RS08655 (SMUFR_1630) | lepB | 1764557..1765144 (+) | 588 | WP_002263358.1 | signal peptidase I | - |
| SMUFR_RS08660 (SMUFR_1631) | - | 1765230..1767593 (+) | 2364 | WP_002263357.1 | ATP-dependent RecD-like DNA helicase | - |
| SMUFR_RS08665 (SMUFR_1632) | - | 1767692..1768162 (+) | 471 | WP_002263356.1 | hypothetical protein | - |
| SMUFR_RS08670 (SMUFR_1633) | - | 1769039..1770031 (+) | 993 | WP_002263355.1 | PTS sugar transporter subunit IIB | - |
| SMUFR_RS08675 (SMUFR_1634) | - | 1770066..1770884 (+) | 819 | WP_002263354.1 | PTS mannose/fructose/sorbose transporter subunit IIC | - |
| SMUFR_RS08680 (SMUFR_1635) | - | 1770899..1771825 (+) | 927 | WP_002263353.1 | PTS system mannose/fructose/sorbose family transporter subunit IID | - |
| SMUFR_RS08685 (SMUFR_1636) | comA/nlmT | 1772157..1774448 (-) | 2292 | WP_002263352.1 | peptide cleavage/export ABC transporter | Regulator |
| SMUFR_RS08690 (SMUFR_1637) | - | 1774998..1775351 (-) | 354 | WP_002263351.1 | hypothetical protein | - |
| SMUFR_RS08695 (SMUFR_1638) | - | 1775670..1776038 (+) | 369 | WP_002263350.1 | DUF956 family protein | - |
| SMUFR_RS08700 (SMUFR_1639) | - | 1776275..1777348 (-) | 1074 | WP_002263349.1 | acyltransferase | - |
| SMUFR_RS08705 (SMUFR_1640) | serS | 1777872..1779152 (+) | 1281 | WP_002263348.1 | serine--tRNA ligase | - |
| SMUFR_RS08710 (SMUFR_1641) | - | 1779835..1780098 (-) | 264 | WP_002352361.1 | Blp family class II bacteriocin | - |
| SMUFR_RS08715 (SMUFR_1642) | - | 1780402..1780587 (-) | 186 | WP_002263346.1 | ComC/BlpC family leader-containing pheromone/bacteriocin | - |
| SMUFR_RS08730 (SMUFR_1645) | - | 1782164..1782325 (-) | 162 | WP_002263734.1 | Blp family class II bacteriocin | - |
| SMUFR_RS08735 (SMUFR_1646) | - | 1782370..1782624 (-) | 255 | WP_002263733.1 | Blp family class II bacteriocin | - |
| SMUFR_RS08745 (SMUFR_1648) | - | 1783081..1785197 (+) | 2117 | Protein_1680 | peptide cleavage/export ABC transporter | - |
| SMUFR_RS08750 (SMUFR_1649) | comB | 1785210..1786223 (+) | 1014 | WP_002263739.1 | HlyD family efflux transporter periplasmic adaptor subunit | Regulator |
| SMUFR_RS10525 | - | 1786485..1786628 (-) | 144 | WP_002263740.1 | hypothetical protein | - |
| SMUFR_RS08755 (SMUFR_1650) | - | 1786920..1787942 (-) | 1023 | WP_002263742.1 | thioredoxin family protein | - |
| SMUFR_RS08760 (SMUFR_1651) | - | 1788428..1788616 (-) | 189 | WP_002263743.1 | Blp family class II bacteriocin | - |
| SMUFR_RS08765 (SMUFR_1652) | - | 1788780..1788992 (-) | 213 | WP_002263744.1 | Blp family class II bacteriocin | - |
| SMUFR_RS10540 (SMUFR_1653) | - | 1789397..1789561 (-) | 165 | WP_002265308.1 | hypothetical protein | - |
| SMUFR_RS10885 | - | 1790001..1790213 (+) | 213 | Protein_1687 | IS3 family transposase | - |
| SMUFR_RS08775 (SMUFR_1654) | - | 1790336..1790740 (-) | 405 | WP_002263912.1 | hypothetical protein | - |
| SMUFR_RS08780 (SMUFR_1655) | - | 1790887..1791306 (-) | 420 | WP_002263913.1 | hypothetical protein | - |
| SMUFR_RS08785 (SMUFR_1657) | - | 1792687..1793088 (-) | 402 | WP_002310604.1 | hypothetical protein | - |
| SMUFR_RS08790 (SMUFR_1658) | cipB | 1793219..1793449 (-) | 231 | WP_002265368.1 | Blp family class II bacteriocin | Regulator |
| SMUFR_RS08795 | comC/blpC | 1793716..1793856 (+) | 141 | WP_002267610.1 | ComC/BlpC family leader-containing pheromone/bacteriocin | Regulator |
| SMUFR_RS08800 (SMUFR_1659) | comD/blpH | 1793998..1795323 (-) | 1326 | WP_002262113.1 | sensor histidine kinase | Regulator |
| SMUFR_RS08805 (SMUFR_1660) | comE/blpR | 1795320..1796072 (-) | 753 | WP_002262114.1 | response regulator transcription factor | Regulator |
| SMUFR_RS08810 (SMUFR_1661) | - | 1796544..1797182 (-) | 639 | WP_002262115.1 | VTT domain-containing protein | - |
| SMUFR_RS08815 (SMUFR_1662) | - | 1797229..1797855 (-) | 627 | WP_002262116.1 | hypothetical protein | - |
| SMUFR_RS08820 (SMUFR_1663) | der | 1797930..1799240 (-) | 1311 | WP_002262117.1 | ribosome biogenesis GTPase Der | - |
| SMUFR_RS08825 (SMUFR_1664) | dnaI | 1799253..1800152 (-) | 900 | WP_002262118.1 | primosomal protein DnaI | - |
| SMUFR_RS08830 (SMUFR_1665) | - | 1800153..1801322 (-) | 1170 | WP_002262119.1 | DnaD domain protein | - |
| SMUFR_RS08835 (SMUFR_1666) | nrdR | 1801309..1801800 (-) | 492 | WP_002262120.1 | transcriptional regulator NrdR | - |
| SMUFR_RS08840 (SMUFR_1667) | covR | 1802170..1802862 (-) | 693 | WP_002262121.1 | response regulator GcrR | Regulator |
| SMUFR_RS08845 (SMUFR_1668) | - | 1803219..1803755 (-) | 537 | WP_002262122.1 | DUF177 domain-containing protein | - |
| SMUFR_RS08850 (SMUFR_1669) | - | 1803748..1804323 (-) | 576 | WP_002262123.1 | TetR/AcrR family transcriptional regulator | - |
| SMUFR_RS08855 (SMUFR_1670) | - | 1804431..1805138 (+) | 708 | WP_002262124.1 | ABC transporter ATP-binding protein | - |
| SMUFR_RS08860 (SMUFR_1671) | - | 1805140..1807752 (+) | 2613 | WP_002263841.1 | ABC transporter permease | - |
| SMUFR_RS08865 (SMUFR_1672) | htpX | 1807889..1808788 (-) | 900 | WP_002262126.1 | zinc metalloprotease HtpX | - |
| SMUFR_RS08870 (SMUFR_1673) | - | 1808798..1809358 (-) | 561 | WP_002262127.1 | LemA family protein | - |
| SMUFR_RS08875 (SMUFR_1674) | rsmG | 1809446..1810159 (+) | 714 | WP_002262128.1 | 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG | - |
| SMUFR_RS08880 (SMUFR_1675) | - | 1810383..1811216 (-) | 834 | WP_002262129.1 | energy-coupling factor transporter transmembrane component T family protein | - |
| SMUFR_RS08885 (SMUFR_1676) | - | 1811209..1812885 (-) | 1677 | WP_002262130.1 | ABC transporter ATP-binding protein | - |
| SMUFR_RS08890 (SMUFR_1677) | - | 1812914..1813459 (-) | 546 | WP_002262131.1 | ECF-type riboflavin transporter substrate-binding protein | - |
| SMUFR_RS08895 (SMUFR_1678) | - | 1813469..1814314 (-) | 846 | WP_002262132.1 | S-adenosyl-l-methionine hydroxide adenosyltransferase family protein | - |
| SMUFR_RS08900 (SMUFR_1679) | - | 1814438..1815214 (-) | 777 | WP_002262133.1 | carbon-nitrogen family hydrolase | - |
| SMUFR_RS08905 (SMUFR_1680) | - | 1815282..1815971 (-) | 690 | WP_002262134.1 | methionine ABC transporter permease | - |
| SMUFR_RS08910 (SMUFR_1681) | - | 1815973..1817037 (-) | 1065 | WP_002262135.1 | methionine ABC transporter ATP-binding protein | - |
| SMUFR_RS08915 (SMUFR_1682) | - | 1817030..1818403 (-) | 1374 | WP_002262136.1 | M20/M25/M40 family metallo-hydrolase | - |
Sequence
Protein
Download Length: 230 a.a. Molecular weight: 26739.72 Da Isoelectric Point: 4.9899
>NTDB_id=115792 SMUFR_RS08840 WP_002262121.1 1802170..1802862(-) (covR) [Streptococcus mutans UA159-FR]
MAKDILIIEDEKKLAKFVSLELQHEGYEVEVTYDGRSGLERALEKDFDLILLDLMLPEMDGYEVIRRLQLEKTTYVIIIT
ARDSIMDIVTGLDRGADGYIVKPFAIEELLARVRAIFRRQDIEKAKHSSKNDTTYRDLKLDVHNRAAIRNGETIPLTKRE
FDLLNALVENINQVMTREELLARVWKYDQEAETNVVDVYIRYLRGKIDVPGKESYIQTVRGMGYIIRENN
MAKDILIIEDEKKLAKFVSLELQHEGYEVEVTYDGRSGLERALEKDFDLILLDLMLPEMDGYEVIRRLQLEKTTYVIIIT
ARDSIMDIVTGLDRGADGYIVKPFAIEELLARVRAIFRRQDIEKAKHSSKNDTTYRDLKLDVHNRAAIRNGETIPLTKRE
FDLLNALVENINQVMTREELLARVWKYDQEAETNVVDVYIRYLRGKIDVPGKESYIQTVRGMGYIIRENN
Nucleotide
Download Length: 693 bp
>NTDB_id=115792 SMUFR_RS08840 WP_002262121.1 1802170..1802862(-) (covR) [Streptococcus mutans UA159-FR]
ATGGCTAAGGACATTTTAATTATTGAAGATGAAAAAAAACTTGCAAAGTTTGTTTCTTTAGAATTACAACATGAAGGATA
TGAGGTTGAAGTGACATATGATGGGCGTTCTGGCCTGGAAAGAGCACTTGAAAAAGATTTCGATCTCATCCTTCTTGATT
TAATGTTACCAGAGATGGACGGGTATGAAGTGATTCGTCGTTTACAATTGGAAAAGACAACTTATGTTATTATTATCACT
GCTCGTGACTCTATTATGGATATTGTGACTGGTCTTGATCGTGGAGCAGATGGTTATATCGTTAAACCATTTGCTATTGA
AGAATTACTAGCTCGTGTTCGTGCCATATTTCGTCGTCAAGATATTGAGAAAGCTAAGCATTCTTCTAAAAATGACACTA
CCTATCGTGATTTGAAATTAGATGTTCATAACCGAGCTGCCATTAGAAATGGTGAGACAATTCCTTTAACTAAACGTGAA
TTTGATTTATTAAATGCTCTTGTAGAAAATATCAATCAAGTCATGACTAGAGAAGAGCTTTTGGCCCGTGTTTGGAAGTA
TGATCAAGAAGCTGAAACTAATGTTGTCGATGTTTATATTCGCTATCTTCGTGGGAAGATTGATGTTCCCGGTAAAGAAA
GCTATATTCAGACTGTCCGCGGCATGGGGTATATCATTCGCGAAAATAATTAA
ATGGCTAAGGACATTTTAATTATTGAAGATGAAAAAAAACTTGCAAAGTTTGTTTCTTTAGAATTACAACATGAAGGATA
TGAGGTTGAAGTGACATATGATGGGCGTTCTGGCCTGGAAAGAGCACTTGAAAAAGATTTCGATCTCATCCTTCTTGATT
TAATGTTACCAGAGATGGACGGGTATGAAGTGATTCGTCGTTTACAATTGGAAAAGACAACTTATGTTATTATTATCACT
GCTCGTGACTCTATTATGGATATTGTGACTGGTCTTGATCGTGGAGCAGATGGTTATATCGTTAAACCATTTGCTATTGA
AGAATTACTAGCTCGTGTTCGTGCCATATTTCGTCGTCAAGATATTGAGAAAGCTAAGCATTCTTCTAAAAATGACACTA
CCTATCGTGATTTGAAATTAGATGTTCATAACCGAGCTGCCATTAGAAATGGTGAGACAATTCCTTTAACTAAACGTGAA
TTTGATTTATTAAATGCTCTTGTAGAAAATATCAATCAAGTCATGACTAGAGAAGAGCTTTTGGCCCGTGTTTGGAAGTA
TGATCAAGAAGCTGAAACTAATGTTGTCGATGTTTATATTCGCTATCTTCGTGGGAAGATTGATGTTCCCGGTAAAGAAA
GCTATATTCAGACTGTCCGCGGCATGGGGTATATCATTCGCGAAAATAATTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| covR | Streptococcus salivarius strain HSISS4 |
78.07 |
99.13 |
0.774 |
| covR | Lactococcus lactis subsp. lactis strain DGCC12653 |
63.436 |
98.696 |
0.626 |
| vicR | Streptococcus mutans UA159 |
42.857 |
100 |
0.43 |
| micA | Streptococcus pneumoniae Cp1015 |
41.631 |
100 |
0.422 |