Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   AD178_RS10190 Genome accession   NZ_OX244288
Coordinates   1964946..1965653 (+) Length   235 a.a.
NCBI ID   WP_000166471.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain PT8105 isolate 2RLC4     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IScluster/Tn 1962914..1964223 1964946..1965653 flank 723


Gene organization within MGE regions


Location: 1962914..1965653
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AD178_RS10175 - 1962914..1963727 (+) 814 Protein_1970 IS5-like element IS1515 family transposase -
  AD178_RS10180 (SAMEA1463109_02055) - 1963834..1964391 (-) 558 Protein_1971 transposase family protein -
  AD178_RS10185 (SAMEA1463109_02056) - 1964377..1964862 (+) 486 WP_000035500.1 cupin domain-containing protein -
  AD178_RS10190 (SAMEA1463109_02057) vicR 1964946..1965653 (+) 708 WP_000166471.1 response regulator transcription factor Regulator

Sequence

Protein


Download         Length: 235 a.a.        Molecular weight: 27212.58 Da        Isoelectric Point: 6.6568

>NTDB_id=1154362 AD178_RS10190 WP_000166471.1 1964946..1965653(+) (vicR) [Streptococcus pneumoniae strain PT8105 isolate 2RLC4]
MTKQVLLVDDEEHILKLLDYHLSKEGFSTQLVTNGRKALALAETEPFDFILLDIMLPQLDGIEVCKRLRAKGVKTPIMMV
SAKSDEFDKVLALELGADDYLTKPFSPRELLARVKAVLRRTKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKANKLLS
LTPKEFELLLYLMKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKAPQFIRTIRGYGYKFKEL

Nucleotide


Download         Length: 708 bp        

>NTDB_id=1154362 AD178_RS10190 WP_000166471.1 1964946..1965653(+) (vicR) [Streptococcus pneumoniae strain PT8105 isolate 2RLC4]
ATGACAAAACAAGTCTTATTAGTGGATGATGAAGAACACATTCTGAAATTGCTTGACTACCATTTAAGTAAGGAAGGCTT
TTCTACTCAATTGGTGACAAATGGACGGAAGGCCTTAGCTTTGGCAGAAACAGAACCCTTTGATTTTATCTTGCTTGATA
TCATGTTACCACAATTAGATGGCATAGAAGTTTGTAAGCGGCTGAGAGCCAAAGGCGTCAAAACTCCAATTATGATGGTT
TCTGCGAAAAGTGATGAATTTGATAAGGTTTTGGCCTTGGAATTAGGGGCTGATGACTACCTGACCAAGCCTTTTAGCCC
TAGAGAATTGCTGGCGCGTGTCAAGGCTGTCCTCAGGCGAACTAAAGGAGAACAAGAAGGAGATGATTCAGATAATATCG
CTGACGATTCTTGGCTATTTGGGACCTTGAAAGTATACCCTGAGCGTCATGAAGTCTACAAGGCGAATAAGTTACTGAGT
TTGACCCCAAAAGAATTTGAACTCTTGCTCTATCTTATGAAACATCCCAACATGACACTGACTAGAGAGCGTCTTTTGGA
ACGTATCTGGGGGTATGACTTTGGGCAGGAAACACGTTTGGTGGACGTTCATATTGGTAAGTTGAGGGAAAAAATTGAAG
ACAATCCTAAAGCCCCTCAATTTATTCGAACCATTCGGGGTTATGGTTATAAGTTCAAGGAGTTATAG

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(159-232)

Response regulator receiver domain (Response_reg)

(5-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

48.707

98.723

0.481
  micA Streptococcus pneumoniae Cp1015

47.845

98.723

0.472
  covR Lactococcus lactis subsp. lactis strain DGCC12653

40.773

99.149

0.404
  covR Streptococcus salivarius strain HSISS4

39.744

99.574

0.396

Multiple sequence alignment