Detailed information
Bioinformatically predicted
Overview
| Name | comE | Type | Machinery gene |
| Locus tag | PMCN01_RS11125 | Genome accession | NZ_CP006976 |
| Coordinates | 2349500..2350834 (+) | Length | 444 a.a. |
| NCBI ID | WP_015702713.1 | Uniprot ID | A0AAW8VA23 |
| Organism | Pasteurella multocida subsp. multocida HB01 | ||
| Function | type IV pilus biogenesis and function (predicted from homology) DNA binding and uptake |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 2294113..2350834 | 2349500..2350834 | within | 0 |
Gene organization within MGE regions
Location: 2294113..2350834
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PMCN01_RS10785 (PMCN01_2110) | - | 2294113..2294958 (+) | 846 | WP_005717653.1 | 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ | - |
| PMCN01_RS10790 (PMCN01_2111) | - | 2295273..2296271 (+) | 999 | WP_064775740.1 | tyrosine-type recombinase/integrase | - |
| PMCN01_RS10795 (PMCN01_2112) | - | 2296416..2296721 (-) | 306 | WP_005723677.1 | heavy-metal-associated domain-containing protein | - |
| PMCN01_RS10800 (PMCN01_2113) | - | 2296731..2297084 (-) | 354 | WP_005723675.1 | mercuric transporter MerT family protein | - |
| PMCN01_RS10805 (PMCN01_2114) | - | 2297056..2298087 (-) | 1032 | Protein_2118 | transglutaminase-like domain-containing protein | - |
| PMCN01_RS10810 (PMCN01_2115) | - | 2298293..2298472 (-) | 180 | WP_016570130.1 | hypothetical protein | - |
| PMCN01_RS11855 (PMCN01_2116) | - | 2298533..2300989 (-) | 2457 | WP_064775697.1 | tail fiber protein | - |
| PMCN01_RS10820 (PMCN01_2117) | - | 2301004..2301570 (-) | 567 | WP_064775698.1 | phage tail protein | - |
| PMCN01_RS10825 (PMCN01_2118) | - | 2301563..2302675 (-) | 1113 | WP_064775699.1 | baseplate assembly protein | - |
| PMCN01_RS10830 (PMCN01_2119) | - | 2302665..2303030 (-) | 366 | WP_064775741.1 | GPW/gp25 family protein | - |
| PMCN01_RS10835 (PMCN01_2120) | - | 2303083..2303664 (-) | 582 | WP_064775700.1 | phage baseplate assembly protein V | - |
| PMCN01_RS10840 (PMCN01_2121) | - | 2303679..2304731 (-) | 1053 | WP_064775701.1 | phage late control D family protein | - |
| PMCN01_RS10845 (PMCN01_2122) | - | 2304731..2304952 (-) | 222 | WP_064775702.1 | tail protein X | - |
| PMCN01_RS10850 (PMCN01_2123) | - | 2304940..2305890 (-) | 951 | WP_064775703.1 | phage tail protein | - |
| PMCN01_RS10855 (PMCN01_2124) | - | 2305899..2308175 (-) | 2277 | WP_235605392.1 | phage tail tape measure protein | - |
| PMCN01_RS10860 (PMCN01_2125) | - | 2308242..2308433 (+) | 192 | WP_064775705.1 | hypothetical protein | - |
| PMCN01_RS11625 (PMCN01_2126) | - | 2308430..2308564 (-) | 135 | WP_227718009.1 | GpE family phage tail protein | - |
| PMCN01_RS10865 (PMCN01_2127) | - | 2308579..2308857 (-) | 279 | WP_064775706.1 | phage tail assembly protein | - |
| PMCN01_RS10870 (PMCN01_2128) | - | 2308940..2309455 (-) | 516 | WP_064775707.1 | phage major tail tube protein | - |
| PMCN01_RS10875 (PMCN01_2129) | - | 2309455..2310846 (-) | 1392 | WP_064775708.1 | phage tail sheath family protein | - |
| PMCN01_RS10880 (PMCN01_2130) | - | 2310856..2311323 (-) | 468 | WP_064775709.1 | Gp37 family protein | - |
| PMCN01_RS10885 (PMCN01_2131) | - | 2311323..2311772 (-) | 450 | WP_064775710.1 | gp436 family protein | - |
| PMCN01_RS10890 (PMCN01_2132) | - | 2311772..2312230 (-) | 459 | WP_064775711.1 | hypothetical protein | - |
| PMCN01_RS10895 (PMCN01_2133) | - | 2312283..2313209 (-) | 927 | WP_064775712.1 | hypothetical protein | - |
| PMCN01_RS10900 (PMCN01_2134) | - | 2313219..2314322 (-) | 1104 | WP_064775713.1 | hypothetical protein | - |
| PMCN01_RS10905 (PMCN01_2135) | - | 2314559..2315014 (-) | 456 | WP_064775714.1 | phage virion morphogenesis protein | - |
| PMCN01_RS10910 (PMCN01_2137) | - | 2315216..2315404 (-) | 189 | WP_064775715.1 | hypothetical protein | - |
| PMCN01_RS10915 (PMCN01_2138) | - | 2315541..2316815 (-) | 1275 | WP_170381806.1 | phage minor head protein | - |
| PMCN01_RS10920 (PMCN01_2139) | - | 2316808..2318253 (-) | 1446 | WP_064775716.1 | DUF935 domain-containing protein | - |
| PMCN01_RS10925 (PMCN01_2140) | - | 2318246..2319802 (-) | 1557 | WP_196768127.1 | terminase large subunit domain-containing protein | - |
| PMCN01_RS10930 (PMCN01_2141) | - | 2319805..2320386 (-) | 582 | WP_064775717.1 | DUF3486 family protein | - |
| PMCN01_RS10935 (PMCN01_2142) | - | 2320409..2320711 (-) | 303 | WP_064775718.1 | winged-helix domain-containing protein | - |
| PMCN01_RS10940 (PMCN01_2143) | - | 2320708..2321037 (-) | 330 | WP_064775719.1 | DUF2730 family protein | - |
| PMCN01_RS10950 (PMCN01_2145) | - | 2321155..2321415 (-) | 261 | WP_064775721.1 | DUF2681 domain-containing protein | - |
| PMCN01_RS10955 (PMCN01_2146) | - | 2321412..2321639 (-) | 228 | WP_064775722.1 | DUF2644 domain-containing protein | - |
| PMCN01_RS10960 (PMCN01_2147) | - | 2321650..2322186 (-) | 537 | WP_064775723.1 | N-acetylmuramoyl-L-alanine amidase | - |
| PMCN01_RS10965 (PMCN01_2148) | - | 2322264..2322626 (-) | 363 | WP_064775724.1 | hypothetical protein | - |
| PMCN01_RS10970 (PMCN01_2149) | - | 2322701..2323075 (-) | 375 | WP_064775725.1 | Mor transcription activator family protein | - |
| PMCN01_RS10975 (PMCN01_2150) | - | 2323075..2323620 (-) | 546 | WP_064775726.1 | hypothetical protein | - |
| PMCN01_RS10980 (PMCN01_2151) | - | 2323617..2324123 (-) | 507 | WP_064775727.1 | gp16 family protein | - |
| PMCN01_RS10985 (PMCN01_2152) | - | 2324197..2324898 (-) | 702 | WP_064775728.1 | DUF2786 domain-containing protein | - |
| PMCN01_RS10990 (PMCN01_2153) | - | 2324907..2325122 (-) | 216 | WP_061406041.1 | hypothetical protein | - |
| PMCN01_RS10995 (PMCN01_2154) | - | 2325140..2325331 (-) | 192 | WP_061406042.1 | ANR family transcriptional regulator | - |
| PMCN01_RS11000 (PMCN01_2155) | - | 2325409..2325927 (-) | 519 | WP_061406043.1 | host-nuclease inhibitor Gam family protein | - |
| PMCN01_RS11005 (PMCN01_2156) | - | 2325920..2326159 (-) | 240 | WP_046339044.1 | hypothetical protein | - |
| PMCN01_RS11010 (PMCN01_2157) | - | 2326369..2326614 (-) | 246 | WP_064775729.1 | hypothetical protein | - |
| PMCN01_RS11015 (PMCN01_2158) | - | 2326635..2326838 (-) | 204 | WP_064775730.1 | hypothetical protein | - |
| PMCN01_RS11020 (PMCN01_2159) | - | 2326838..2327755 (-) | 918 | WP_016533375.1 | AAA family ATPase | - |
| PMCN01_RS11025 (PMCN01_2160) | - | 2327782..2329785 (-) | 2004 | WP_064775731.1 | transposase domain-containing protein | - |
| PMCN01_RS11030 | - | 2329769..2330002 (-) | 234 | WP_235605393.1 | helix-turn-helix domain-containing protein | - |
| PMCN01_RS11035 (PMCN01_2161) | - | 2330245..2330718 (+) | 474 | WP_081273992.1 | DNA-binding protein | - |
| PMCN01_RS11040 (PMCN01_2162) | tkt | 2331071..2332798 (+) | 1728 | Protein_2165 | transketolase | - |
| PMCN01_RS11045 (PMCN01_2163) | rpoD | 2332894..2334762 (-) | 1869 | WP_064775694.1 | RNA polymerase sigma factor RpoD | - |
| PMCN01_RS11050 (PMCN01_2164) | dnaG | 2334838..2336586 (-) | 1749 | WP_005751910.1 | DNA primase | - |
| PMCN01_RS11055 (PMCN01_2165) | rpsU | 2336702..2336917 (-) | 216 | WP_005717672.1 | 30S ribosomal protein S21 | - |
| PMCN01_RS11060 (PMCN01_2166) | tsaD | 2337136..2338167 (+) | 1032 | WP_005723723.1 | tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD | - |
| PMCN01_RS11065 (PMCN01_2167) | - | 2338188..2338424 (+) | 237 | WP_005717662.1 | hypothetical protein | - |
| PMCN01_RS11070 (PMCN01_2168) | - | 2338426..2339004 (+) | 579 | WP_005717659.1 | thymidine kinase | - |
| PMCN01_RS11075 (PMCN01_2169) | gorA | 2339092..2340447 (-) | 1356 | WP_015702704.1 | glutathione-disulfide reductase | - |
| PMCN01_RS11080 (PMCN01_2170) | - | 2340544..2341389 (-) | 846 | WP_015702705.1 | 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ | - |
| PMCN01_RS11085 (PMCN01_2171) | pdxT | 2341550..2342131 (-) | 582 | WP_015702706.1 | pyridoxal 5'-phosphate synthase glutaminase subunit PdxT | - |
| PMCN01_RS11090 (PMCN01_2172) | pdxS | 2342134..2343021 (-) | 888 | WP_015702707.1 | pyridoxal 5'-phosphate synthase lyase subunit PdxS | - |
| PMCN01_RS11095 (PMCN01_2173) | - | 2343132..2344544 (+) | 1413 | WP_016504289.1 | PLP-dependent aminotransferase family protein | - |
| PMCN01_RS11100 (PMCN01_2174) | - | 2344576..2347137 (-) | 2562 | WP_015702709.1 | penicillin-binding protein 1A | - |
| PMCN01_RS11105 (PMCN01_2175) | - | 2347273..2348046 (+) | 774 | WP_015702710.1 | pilus assembly protein PilM | - |
| PMCN01_RS11110 (PMCN01_2176) | - | 2348086..2348601 (+) | 516 | WP_015702711.1 | hypothetical protein | - |
| PMCN01_RS11115 (PMCN01_2177) | - | 2348601..2349125 (+) | 525 | WP_005751903.1 | hypothetical protein | - |
| PMCN01_RS11120 (PMCN01_2178) | - | 2349128..2349490 (+) | 363 | WP_015702712.1 | pilus assembly protein PilP | - |
| PMCN01_RS11125 (PMCN01_2179) | comE | 2349500..2350834 (+) | 1335 | WP_015702713.1 | type IV pilus secretin PilQ | Machinery gene |
Sequence
Protein
Download Length: 444 a.a. Molecular weight: 49246.60 Da Isoelectric Point: 8.0315
>NTDB_id=115404 PMCN01_RS11125 WP_015702713.1 2349500..2350834(+) (comE) [Pasteurella multocida subsp. multocida HB01]
MWRAFRKISFVYFLCGVAYVGSSQAQDAEHFYLRLKQAPLVEMLQYLALQQHQDLLIDDHLEGTLSLQMKKTTFEKCLQS
IARMKQLELHQEGKSYYLTSPSGVAANDTHHPTSLMTSSIKLHFAKAAEVVKSLTSGQGSLLSVGGSLSFDERTNLLLIQ
DEPQSIQRIKALVAEMDKPIEQIAIEARIVTMTDESLQELGVRWGLFQATEQAHTIAGSLAANGFSNIENQLNVNFSTNS
TPVGSIALQLAKINGRLLDLELTALEREKHIEIIASPRLLTTNKKSASIKQGTEIPYVMKRGKDKSESVEFREAVLGLDV
TPHISKDNSILLDLLITQNTLGAPVVYDKGEIVSIDKQEINTQVVAQDGETIVLGGVFHDTMTKGVNKVPLLGDLPLLKH
VFSQKTERHQKRELVIFVTPHIIKSSQGSPEQKTTRVKKSAKSR
MWRAFRKISFVYFLCGVAYVGSSQAQDAEHFYLRLKQAPLVEMLQYLALQQHQDLLIDDHLEGTLSLQMKKTTFEKCLQS
IARMKQLELHQEGKSYYLTSPSGVAANDTHHPTSLMTSSIKLHFAKAAEVVKSLTSGQGSLLSVGGSLSFDERTNLLLIQ
DEPQSIQRIKALVAEMDKPIEQIAIEARIVTMTDESLQELGVRWGLFQATEQAHTIAGSLAANGFSNIENQLNVNFSTNS
TPVGSIALQLAKINGRLLDLELTALEREKHIEIIASPRLLTTNKKSASIKQGTEIPYVMKRGKDKSESVEFREAVLGLDV
TPHISKDNSILLDLLITQNTLGAPVVYDKGEIVSIDKQEINTQVVAQDGETIVLGGVFHDTMTKGVNKVPLLGDLPLLKH
VFSQKTERHQKRELVIFVTPHIIKSSQGSPEQKTTRVKKSAKSR
Nucleotide
Download Length: 1335 bp
>NTDB_id=115404 PMCN01_RS11125 WP_015702713.1 2349500..2350834(+) (comE) [Pasteurella multocida subsp. multocida HB01]
ATGTGGCGAGCATTCAGAAAAATATCTTTTGTGTACTTTTTATGTGGGGTTGCTTATGTTGGAAGTAGTCAAGCACAAGA
CGCAGAACATTTTTATTTACGTTTAAAACAAGCGCCTTTAGTCGAAATGTTACAGTATTTAGCATTGCAACAACATCAGG
ATTTGTTAATCGATGATCATTTAGAGGGCACATTATCATTACAGATGAAAAAGACAACCTTTGAGAAATGTTTACAGTCG
ATTGCAAGAATGAAACAACTTGAGTTACATCAAGAAGGAAAATCCTATTATTTAACTTCCCCTTCAGGTGTTGCAGCAAA
CGATACTCATCATCCTACGTCATTGATGACATCTTCAATAAAATTGCATTTTGCCAAAGCTGCAGAGGTGGTGAAATCTT
TAACTTCAGGGCAGGGAAGTTTACTTTCTGTCGGGGGGAGTTTGAGTTTTGATGAGCGGACTAATTTACTGCTGATTCAG
GATGAACCGCAATCAATACAGCGTATTAAAGCATTAGTAGCAGAAATGGATAAACCCATTGAACAAATTGCGATCGAAGC
TAGGATTGTGACGATGACAGACGAAAGTTTGCAGGAACTTGGTGTAAGATGGGGGCTATTTCAAGCAACAGAACAGGCAC
ATACTATTGCGGGGAGTTTAGCCGCGAACGGCTTTTCGAATATAGAAAACCAATTAAATGTGAATTTCTCGACCAATAGT
ACACCTGTTGGTTCCATCGCCTTACAGTTGGCGAAAATAAATGGTCGATTATTAGACTTGGAATTAACTGCCTTGGAGCG
AGAAAAGCATATTGAGATTATTGCGAGTCCTCGTTTATTAACAACGAATAAAAAAAGTGCCAGTATCAAACAAGGGACGG
AAATTCCTTATGTGATGAAACGGGGAAAAGATAAAAGCGAATCGGTGGAATTTCGAGAAGCTGTATTGGGTTTAGATGTG
ACACCGCATATCTCAAAAGACAACTCGATTTTATTAGATTTATTGATTACACAAAATACATTAGGTGCACCGGTAGTGTA
TGATAAAGGCGAAATTGTTTCGATCGATAAACAGGAAATCAATACTCAAGTCGTCGCTCAAGATGGTGAAACCATCGTTT
TAGGTGGGGTGTTTCATGATACGATGACAAAGGGAGTCAATAAAGTACCACTACTAGGGGATTTGCCTTTGCTTAAACAT
GTGTTTAGCCAGAAAACTGAACGTCATCAAAAGCGGGAATTAGTGATTTTTGTCACTCCTCATATTATCAAATCTAGCCA
AGGTTCGCCTGAACAAAAAACAACAAGAGTTAAAAAATCTGCAAAATCAAGGTGA
ATGTGGCGAGCATTCAGAAAAATATCTTTTGTGTACTTTTTATGTGGGGTTGCTTATGTTGGAAGTAGTCAAGCACAAGA
CGCAGAACATTTTTATTTACGTTTAAAACAAGCGCCTTTAGTCGAAATGTTACAGTATTTAGCATTGCAACAACATCAGG
ATTTGTTAATCGATGATCATTTAGAGGGCACATTATCATTACAGATGAAAAAGACAACCTTTGAGAAATGTTTACAGTCG
ATTGCAAGAATGAAACAACTTGAGTTACATCAAGAAGGAAAATCCTATTATTTAACTTCCCCTTCAGGTGTTGCAGCAAA
CGATACTCATCATCCTACGTCATTGATGACATCTTCAATAAAATTGCATTTTGCCAAAGCTGCAGAGGTGGTGAAATCTT
TAACTTCAGGGCAGGGAAGTTTACTTTCTGTCGGGGGGAGTTTGAGTTTTGATGAGCGGACTAATTTACTGCTGATTCAG
GATGAACCGCAATCAATACAGCGTATTAAAGCATTAGTAGCAGAAATGGATAAACCCATTGAACAAATTGCGATCGAAGC
TAGGATTGTGACGATGACAGACGAAAGTTTGCAGGAACTTGGTGTAAGATGGGGGCTATTTCAAGCAACAGAACAGGCAC
ATACTATTGCGGGGAGTTTAGCCGCGAACGGCTTTTCGAATATAGAAAACCAATTAAATGTGAATTTCTCGACCAATAGT
ACACCTGTTGGTTCCATCGCCTTACAGTTGGCGAAAATAAATGGTCGATTATTAGACTTGGAATTAACTGCCTTGGAGCG
AGAAAAGCATATTGAGATTATTGCGAGTCCTCGTTTATTAACAACGAATAAAAAAAGTGCCAGTATCAAACAAGGGACGG
AAATTCCTTATGTGATGAAACGGGGAAAAGATAAAAGCGAATCGGTGGAATTTCGAGAAGCTGTATTGGGTTTAGATGTG
ACACCGCATATCTCAAAAGACAACTCGATTTTATTAGATTTATTGATTACACAAAATACATTAGGTGCACCGGTAGTGTA
TGATAAAGGCGAAATTGTTTCGATCGATAAACAGGAAATCAATACTCAAGTCGTCGCTCAAGATGGTGAAACCATCGTTT
TAGGTGGGGTGTTTCATGATACGATGACAAAGGGAGTCAATAAAGTACCACTACTAGGGGATTTGCCTTTGCTTAAACAT
GTGTTTAGCCAGAAAACTGAACGTCATCAAAAGCGGGAATTAGTGATTTTTGTCACTCCTCATATTATCAAATCTAGCCA
AGGTTCGCCTGAACAAAAAACAACAAGAGTTAAAAAATCTGCAAAATCAAGGTGA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comE | Haemophilus influenzae Rd KW20 |
62.269 |
97.297 |
0.606 |
| comE | Haemophilus influenzae 86-028NP |
61.574 |
97.297 |
0.599 |
| comE | Glaesserella parasuis strain SC1401 |
49.192 |
97.523 |
0.48 |
| pilQ | Vibrio campbellii strain DS40M4 |
39.524 |
94.595 |
0.374 |
| pilQ | Vibrio cholerae O1 biovar El Tor strain E7946 |
39.563 |
92.793 |
0.367 |
| pilQ | Vibrio cholerae strain A1552 |
39.563 |
92.793 |
0.367 |