Detailed information
Bioinformatically predicted
Overview
| Name | comE | Type | Machinery gene |
| Locus tag | LSO74_RS03470 | Genome accession | NZ_OV040719 |
| Coordinates | 659675..661012 (+) | Length | 445 a.a. |
| NCBI ID | WP_005659796.1 | Uniprot ID | - |
| Organism | Haemophilus influenzae strain 3655 isolate 3655 | ||
| Function | type IV pilus biogenesis and function (predicted from homology) DNA binding and uptake |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 634733..666815 | 659675..661012 | within | 0 |
Gene organization within MGE regions
Location: 634733..666815
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LSO74_RS03310 (KRLU3655_LOCUS623) | gpU | 634733..635131 (+) | 399 | WP_005656495.1 | phage tail terminator protein | - |
| LSO74_RS03315 (KRLU3655_LOCUS624) | - | 635141..636331 (+) | 1191 | WP_005656494.1 | phage major capsid protein | - |
| LSO74_RS03320 (KRLU3655_LOCUS625) | - | 636376..636942 (+) | 567 | WP_005656493.1 | HK97 family phage prohead protease | - |
| LSO74_RS03325 (KRLU3655_LOCUS626) | - | 636944..638176 (+) | 1233 | WP_005656492.1 | phage portal protein | - |
| LSO74_RS03330 (KRLU3655_LOCUS627) | - | 638160..638516 (+) | 357 | WP_005626382.1 | phage head closure protein | - |
| LSO74_RS03335 (KRLU3655_LOCUS628) | - | 638503..638817 (+) | 315 | WP_005656491.1 | head-tail connector protein | - |
| LSO74_RS03340 | - | 638834..639190 (+) | 357 | WP_032821891.1 | HNH endonuclease signature motif containing protein | - |
| LSO74_RS03345 (KRLU3655_LOCUS629) | - | 639421..639795 (+) | 375 | WP_005626376.1 | phage terminase small subunit P27 family | - |
| LSO74_RS03350 (KRLU3655_LOCUS630) | - | 639803..641470 (+) | 1668 | WP_005656489.1 | terminase large subunit | - |
| LSO74_RS03355 (KRLU3655_LOCUS631) | - | 641486..641953 (+) | 468 | WP_005656488.1 | HK97-gp10 family putative phage morphogenesis protein | - |
| LSO74_RS03360 (KRLU3655_LOCUS632) | - | 642227..642526 (+) | 300 | WP_005656487.1 | hypothetical protein | - |
| LSO74_RS03365 (KRLU3655_LOCUS633) | - | 642634..643638 (+) | 1005 | WP_005656486.1 | hypothetical protein | - |
| LSO74_RS03370 (KRLU3655_LOCUS634) | - | 643782..643985 (+) | 204 | WP_005656485.1 | helix-turn-helix transcriptional regulator | - |
| LSO74_RS03375 (KRLU3655_LOCUS635) | - | 644091..645032 (+) | 942 | WP_050397188.1 | host cell division inhibitor Icd-like protein | - |
| LSO74_RS03380 (KRLU3655_LOCUS636) | - | 645025..645396 (+) | 372 | WP_005656483.1 | hypothetical protein | - |
| LSO74_RS03385 (KRLU3655_LOCUS637) | - | 645386..645589 (+) | 204 | WP_005656482.1 | hypothetical protein | - |
| LSO74_RS03390 (KRLU3655_LOCUS638) | - | 645579..645785 (+) | 207 | WP_005629564.1 | hypothetical protein | - |
| LSO74_RS03395 (KRLU3655_LOCUS639) | - | 645772..646296 (+) | 525 | WP_005656481.1 | hypothetical protein | - |
| LSO74_RS03400 (KRLU3655_LOCUS640) | - | 646298..646741 (+) | 444 | WP_005656479.1 | hypothetical protein | - |
| LSO74_RS03405 (KRLU3655_LOCUS641) | - | 646725..648494 (+) | 1770 | WP_005656478.1 | phage/plasmid primase, P4 family | - |
| LSO74_RS03410 (KRLU3655_LOCUS642) | - | 648666..649892 (-) | 1227 | WP_005656477.1 | tyrosine-type recombinase/integrase | - |
| LSO74_RS03420 (KRLU3655_LOCUS643) | secG | 650190..650531 (-) | 342 | WP_005656476.1 | preprotein translocase subunit SecG | - |
| LSO74_RS03425 (KRLU3655_LOCUS644) | - | 650640..652595 (-) | 1956 | WP_005656475.1 | DNA topoisomerase III | - |
| LSO74_RS03430 (KRLU3655_LOCUS645) | recR | 652611..653213 (-) | 603 | WP_005656473.1 | recombination mediator RecR | - |
| LSO74_RS03435 (KRLU3655_LOCUS646) | - | 653343..653672 (-) | 330 | WP_005629464.1 | YbaB/EbfC family nucleoid-associated protein | - |
| LSO74_RS03440 (KRLU3655_LOCUS647) | - | 653825..654670 (-) | 846 | WP_005656472.1 | 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ | - |
| LSO74_RS03445 (KRLU3655_LOCUS648) | - | 654743..657337 (-) | 2595 | WP_005656471.1 | penicillin-binding protein 1A | - |
| LSO74_RS03450 (KRLU3655_LOCUS649) | comA | 657433..658230 (+) | 798 | WP_005656469.1 | pilus assembly protein PilM | Machinery gene |
| LSO74_RS03455 (KRLU3655_LOCUS650) | comB | 658231..658737 (+) | 507 | WP_005656467.1 | competence protein ComB | Machinery gene |
| LSO74_RS03460 (KRLU3655_LOCUS651) | comC | 658734..659255 (+) | 522 | WP_005656465.1 | competence protein ComC | Machinery gene |
| LSO74_RS03465 (KRLU3655_LOCUS652) | comD | 659252..659665 (+) | 414 | WP_005656464.1 | pilus assembly protein PilP | Machinery gene |
| LSO74_RS03470 (KRLU3655_LOCUS653) | comE | 659675..661012 (+) | 1338 | WP_005659796.1 | type IV pilus secretin PilQ family protein | Machinery gene |
| LSO74_RS03475 (KRLU3655_LOCUS654) | - | 661025..661711 (+) | 687 | WP_005656460.1 | ComF family protein | - |
| LSO74_RS03480 (KRLU3655_LOCUS655) | nfuA | 661787..662383 (+) | 597 | WP_005656459.1 | Fe-S biogenesis protein NfuA | - |
| LSO74_RS03485 (KRLU3655_LOCUS656) | nudC | 662450..663244 (+) | 795 | WP_005656457.1 | NAD(+) diphosphatase | - |
| LSO74_RS03490 (KRLU3655_LOCUS657) | - | 663280..663870 (+) | 591 | WP_005656455.1 | YjaG family protein | - |
| LSO74_RS03495 (KRLU3655_LOCUS658) | - | 664010..664282 (+) | 273 | WP_005630954.1 | HU family DNA-binding protein | - |
| LSO74_RS03500 (KRLU3655_LOCUS659) | glmS | 664395..666227 (+) | 1833 | WP_005656453.1 | glutamine--fructose-6-phosphate transaminase (isomerizing) | - |
| LSO74_RS03505 (KRLU3655_LOCUS660) | dsbB | 666282..666815 (-) | 534 | WP_005656451.1 | disulfide bond formation protein DsbB | - |
Sequence
Protein
Download Length: 445 a.a. Molecular weight: 49108.40 Da Isoelectric Point: 7.4794
>NTDB_id=1151769 LSO74_RS03470 WP_005659796.1 659675..661012(+) (comE) [Haemophilus influenzae strain 3655 isolate 3655]
MKKYFLKCGCFLVFFCLPLIVFANPKTDNERFFIRLSQAPLAQTVEQLAFQQDVNLVIGDILESKISLKLNNIDMPRLLK
IIAKSKHLTLNKDDGIYYLNGSQSGKGEVAGNLTTNEPHLVSHTVKLHFAKASELMKSLTTGSGSLLSPDGSITFDDRSN
LLVIQDEPRSVQNIKKLIAEMDKPIEQIAIEARIVTITDESLKELGVRWGIFNPTENARRVAGSLAGNSFENIADNLNVN
FATTTTPAGSIALQVAKINGRLLDLELSALERENNVEIIASPRLLTTNKKSASIKQGTEIPYIVSNTRNDTQSVEFREAV
LGLEVTPHISKDNNILLDLLVSQNSPGSRVAYGQNEVVSIDKQEINTQVFAKDGETIVLGGVFHDTITKSEDKVPLLGDI
PVIKRLFSKESERHQKRELVIFVTPHILKAGETLEALKQKSAGKK
MKKYFLKCGCFLVFFCLPLIVFANPKTDNERFFIRLSQAPLAQTVEQLAFQQDVNLVIGDILESKISLKLNNIDMPRLLK
IIAKSKHLTLNKDDGIYYLNGSQSGKGEVAGNLTTNEPHLVSHTVKLHFAKASELMKSLTTGSGSLLSPDGSITFDDRSN
LLVIQDEPRSVQNIKKLIAEMDKPIEQIAIEARIVTITDESLKELGVRWGIFNPTENARRVAGSLAGNSFENIADNLNVN
FATTTTPAGSIALQVAKINGRLLDLELSALERENNVEIIASPRLLTTNKKSASIKQGTEIPYIVSNTRNDTQSVEFREAV
LGLEVTPHISKDNNILLDLLVSQNSPGSRVAYGQNEVVSIDKQEINTQVFAKDGETIVLGGVFHDTITKSEDKVPLLGDI
PVIKRLFSKESERHQKRELVIFVTPHILKAGETLEALKQKSAGKK
Nucleotide
Download Length: 1338 bp
>NTDB_id=1151769 LSO74_RS03470 WP_005659796.1 659675..661012(+) (comE) [Haemophilus influenzae strain 3655 isolate 3655]
ATGAAGAAATATTTTTTAAAGTGCGGTTGTTTTTTAGTATTTTTTTGTTTGCCATTAATCGTTTTTGCTAATCCTAAAAC
AGATAACGAACGTTTTTTTATTCGTTTATCGCAAGCACCTTTAGCTCAAACAGTGGAGCAATTAGCTTTTCAACAAGATG
TGAATTTAGTGATTGGAGATATATTGGAAAGCAAGATCTCTTTGAAATTAAACAATATTGATATGCCACGTTTGCTAAAA
ATAATCGCAAAAAGTAAGCATCTTACTTTGAATAAAGATGATGGGATTTATTATTTAAACGGCAGTCAATCTGGCAAAGG
TGAAGTTGCAGGAAATCTTACGACAAATGAACCGCACTTAGTGAGTCACACGGTAAAACTCCATTTTGCTAAAGCCTCTG
AATTAATGAAATCTTTAACAACAGGAAGTGGCTCTTTGCTTTCTCCCGATGGGAGCATTACCTTTGATGATCGCAGTAAT
TTGCTGGTTATTCAGGATGAACCTCGTTCTGTGCAAAATATCAAAAAACTGATTGCTGAAATGGATAAGCCTATTGAACA
GATCGCTATTGAAGCGCGAATTGTGACAATTACGGATGAGAGTTTGAAAGAACTTGGCGTTCGGTGGGGGATTTTTAATC
CAACTGAAAATGCAAGACGAGTTGCGGGCAGCCTCGCAGGCAATAGCTTTGAAAATATTGCGGATAATCTTAATGTAAAT
TTTGCGACAACGACGACACCTGCTGGCTCTATAGCATTACAAGTCGCGAAAATTAATGGGCGATTGCTTGATTTAGAATT
GAGTGCGTTGGAGCGTGAAAATAATGTAGAAATTATTGCAAGTCCTCGCTTACTCACTACCAATAAGAAAAGTGCGAGCA
TTAAACAGGGGACAGAAATTCCTTACATCGTGAGCAATACTCGTAACGATACGCAATCTGTGGAATTTCGTGAGGCAGTA
CTTGGTTTGGAAGTGACGCCGCATATTTCTAAAGATAACAATATCTTACTTGATTTATTGGTAAGTCAAAATTCCCCTGG
TTCTCGTGTCGCTTATGGACAAAATGAGGTGGTTTCTATTGATAAGCAAGAAATTAATACTCAGGTTTTTGCCAAAGATG
GGGAAACCATTGTGCTTGGCGGCGTATTTCACGACACAATCACGAAAAGCGAAGATAAAGTGCCATTGCTTGGCGATATA
CCCGTTATTAAACGATTATTTAGCAAAGAAAGTGAACGACATCAAAAACGTGAGCTCGTGATTTTCGTGACGCCACATAT
TTTAAAAGCAGGAGAAACGTTAGAGGCGTTGAAACAAAAAAGTGCGGGCAAAAAATAA
ATGAAGAAATATTTTTTAAAGTGCGGTTGTTTTTTAGTATTTTTTTGTTTGCCATTAATCGTTTTTGCTAATCCTAAAAC
AGATAACGAACGTTTTTTTATTCGTTTATCGCAAGCACCTTTAGCTCAAACAGTGGAGCAATTAGCTTTTCAACAAGATG
TGAATTTAGTGATTGGAGATATATTGGAAAGCAAGATCTCTTTGAAATTAAACAATATTGATATGCCACGTTTGCTAAAA
ATAATCGCAAAAAGTAAGCATCTTACTTTGAATAAAGATGATGGGATTTATTATTTAAACGGCAGTCAATCTGGCAAAGG
TGAAGTTGCAGGAAATCTTACGACAAATGAACCGCACTTAGTGAGTCACACGGTAAAACTCCATTTTGCTAAAGCCTCTG
AATTAATGAAATCTTTAACAACAGGAAGTGGCTCTTTGCTTTCTCCCGATGGGAGCATTACCTTTGATGATCGCAGTAAT
TTGCTGGTTATTCAGGATGAACCTCGTTCTGTGCAAAATATCAAAAAACTGATTGCTGAAATGGATAAGCCTATTGAACA
GATCGCTATTGAAGCGCGAATTGTGACAATTACGGATGAGAGTTTGAAAGAACTTGGCGTTCGGTGGGGGATTTTTAATC
CAACTGAAAATGCAAGACGAGTTGCGGGCAGCCTCGCAGGCAATAGCTTTGAAAATATTGCGGATAATCTTAATGTAAAT
TTTGCGACAACGACGACACCTGCTGGCTCTATAGCATTACAAGTCGCGAAAATTAATGGGCGATTGCTTGATTTAGAATT
GAGTGCGTTGGAGCGTGAAAATAATGTAGAAATTATTGCAAGTCCTCGCTTACTCACTACCAATAAGAAAAGTGCGAGCA
TTAAACAGGGGACAGAAATTCCTTACATCGTGAGCAATACTCGTAACGATACGCAATCTGTGGAATTTCGTGAGGCAGTA
CTTGGTTTGGAAGTGACGCCGCATATTTCTAAAGATAACAATATCTTACTTGATTTATTGGTAAGTCAAAATTCCCCTGG
TTCTCGTGTCGCTTATGGACAAAATGAGGTGGTTTCTATTGATAAGCAAGAAATTAATACTCAGGTTTTTGCCAAAGATG
GGGAAACCATTGTGCTTGGCGGCGTATTTCACGACACAATCACGAAAAGCGAAGATAAAGTGCCATTGCTTGGCGATATA
CCCGTTATTAAACGATTATTTAGCAAAGAAAGTGAACGACATCAAAAACGTGAGCTCGTGATTTTCGTGACGCCACATAT
TTTAAAAGCAGGAGAAACGTTAGAGGCGTTGAAACAAAAAAGTGCGGGCAAAAAATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comE | Haemophilus influenzae Rd KW20 |
97.978 |
100 |
0.98 |
| comE | Haemophilus influenzae 86-028NP |
96.629 |
100 |
0.966 |
| comE | Glaesserella parasuis strain SC1401 |
52.204 |
96.854 |
0.506 |
| pilQ | Vibrio campbellii strain DS40M4 |
41.844 |
95.056 |
0.398 |
| pilQ | Vibrio cholerae O1 biovar El Tor strain E7946 |
41.505 |
92.584 |
0.384 |
| pilQ | Vibrio cholerae strain A1552 |
41.505 |
92.584 |
0.384 |