Detailed information NTG1147233

Bioinformatically predicted

Overview

• Name: letS
• Type: Regulator
• Locus tag: CKW04_RS06650
• Genome accession: NZ_LT906442
• Coordinates: 1413687..1416419 (-)
• Length: 910 a.a.
• NCBI ID: WP_083500025.1
• Uniprot ID: A0A0W1AMB6
• Organism: Legionella waltersii strain NCTC13017
• Function: regulate competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1408687..1421419

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CKW04_RS06625 (SAMEA4504053_01350)	-	1409243..1410667 (-)	1425	WP_058479450.1	APC family permease	-
CKW04_RS06630 (SAMEA4504053_01351)	-	1410733..1411050 (-)	318	WP_058479451.1	BolA family transcriptional regulator	-
CKW04_RS06635 (SAMEA4504053_01352)	pilA2	1411335..1411748 (+)	414	WP_058479452.1	pilin	Machinery gene
CKW04_RS06640 (SAMEA4504053_01353)	pilA2	1412025..1412438 (+)	414	WP_058479453.1	pilin	Machinery gene
CKW04_RS06645 (SAMEA4504053_01354)	-	1412435..1413673 (-)	1239	WP_058479483.1	6-phosphofructokinase	-
CKW04_RS06650 (SAMEA4504053_01355)	letS	1413687..1416419 (-)	2733	WP_083500025.1	two-component system sensor histidine kinase LetS	Regulator
CKW04_RS06655 (SAMEA4504053_01356)	gltX	1416512..1417924 (+)	1413	WP_058479454.1	glutamate--tRNA ligase	-
CKW04_RS06660 (SAMEA4504053_01357)	-	1418558..1419826 (+)	1269	WP_058479455.1	serine hydrolase	-
CKW04_RS06665 (SAMEA4504053_01358)	-	1419841..1420821 (+)	981	WP_058479456.1	hypothetical protein	-

Sequence

Protein

• Length: 910 a.a.
• Molecular weight: 103143.25 Da
• Isoelectric Point: 6.8431

>NTDB_id=1147233 CKW04_RS06650 WP_083500025.1 1413687..1416419(-) (letS) [Legionella waltersii strain NCTC13017]
MLKSIGIKYQLRITTLIPAFLVALLFAFFYNVQFGKDLEQYMSRLGEAYIRQLLPAAQYAMLKNDYRTLQGLINASTINP
EVKALAFYNSDGQLIAYRGGKHSLHKPFNPPDYTGDYIESKQINPFTINFIAPITLPKFNLYSRPEMRNLPTLSSFQADD
ILGWLSIDIDTQSMLLKRYQMMIITIFITLLGLLMGLTIHYFLSKQIYLPIARLRRSMKQITSNEFETEIKVSSPGELGI
IEKGCQHLQHQYLNTVRDLNHHIEVATADLQQSLELLEEKNIELSLEKKKTEEKSRQKSEFIANMSHEIRTPMNGVIGFT
NVLLETKLDPLQLDYVKTIKTSAQDLLSIINDILDFSKMDAGKLNLDCIPVDIRGCVDEVLSLASPNAHKKGIDLIPITD
VDVPKTVLGDPLRIKQIISNLVTNAIKFTDHGYVLVRTKIEQETDKDYTLLISISDTGIGISQEDQNKLFTAFNQADTSI
TRRYGGSGLGLVICKKLCEQMHGRISLSSEVNKGSTFNARIKVEKLMAYEIEKNQIHRFSHLKIICFDDHSLHLEALCNG
LGFWGIECVKVNSFTNISSTINKHKECTIVFMNVNQGCEQQAVELIKKHPTMPFVLISKWPINNYSALGARGFLYKPISI
QKLQDLIESINNEKKPEDHSAHELDGLREQLRYVHPHLLIAEDNPVNKMLITSLLKEQANITAVDDGEMAVKACEETKFD
VILLDLQMPKLDGLQASKSIRQSSLMNKHTPIVLITASSNDLNNAEMKQSGIDLYLQKPVEEKQLLIQILRIINKSTHAA
IDWELCVQKVSGNQALAEEFLAKFIEELYKARDEFIQLMHDKNIHSLADAAHKLHGACCFCGVPVLQKKVTQFEKLAKRT
SHIDHLNEAFAELIQSIDAVINEYENQYSH

Nucleotide

• Length: 2733 bp

>NTDB_id=1147233 CKW04_RS06650 WP_083500025.1 1413687..1416419(-) (letS) [Legionella waltersii strain NCTC13017]
ATGTTGAAAAGTATTGGTATCAAATATCAACTTCGAATTACCACCCTTATACCGGCTTTCTTAGTTGCCCTTCTTTTTGC
ATTTTTCTACAACGTTCAATTTGGGAAAGATCTTGAGCAATATATGTCTAGATTAGGAGAGGCCTACATTAGACAGTTAT
TACCAGCTGCCCAGTATGCCATGCTAAAAAATGATTACCGTACTCTACAAGGACTGATTAATGCTTCAACCATAAACCCT
GAAGTTAAAGCCCTGGCTTTCTATAATTCTGATGGACAGTTAATCGCCTATCGTGGAGGAAAGCATTCATTGCATAAACC
GTTCAATCCACCTGACTATACTGGAGACTACATTGAAAGTAAGCAAATAAACCCTTTCACCATTAACTTCATAGCTCCAA
TTACTTTACCAAAATTTAACTTATATTCGCGTCCTGAAATGCGAAACTTGCCCACACTGTCTTCATTTCAAGCCGATGAT
ATTCTCGGGTGGTTATCAATTGATATTGACACACAGTCCATGTTGCTCAAACGGTATCAAATGATGATTATAACCATTTT
TATCACCTTGTTAGGTTTGTTAATGGGACTAACGATTCATTATTTCCTATCTAAACAAATCTATTTACCAATTGCTCGTC
TACGCCGTAGCATGAAGCAAATAACAAGCAATGAGTTTGAAACTGAAATCAAAGTATCCAGTCCCGGTGAATTAGGCATT
ATTGAAAAAGGATGCCAACACCTTCAGCACCAGTATTTAAATACCGTTCGCGATTTGAATCACCATATCGAAGTAGCAAC
AGCCGATTTACAACAAAGTTTGGAACTTCTTGAAGAAAAAAACATCGAGCTGTCTCTAGAAAAAAAGAAGACTGAAGAAA
AGAGCAGGCAAAAGTCTGAATTCATTGCCAACATGAGTCATGAGATTCGTACGCCTATGAATGGAGTGATAGGATTTACC
AACGTACTGTTAGAAACAAAACTCGACCCCTTACAACTGGATTACGTAAAAACCATTAAGACTTCAGCCCAAGATTTGTT
GAGTATCATTAACGATATACTAGACTTCTCAAAAATGGATGCCGGTAAACTCAATTTAGATTGCATACCAGTAGATATAC
GTGGCTGCGTCGATGAAGTTTTATCACTGGCATCGCCTAATGCCCATAAAAAGGGAATTGATTTGATCCCTATTACCGAC
GTTGATGTTCCCAAAACAGTGCTCGGAGATCCATTAAGGATTAAACAAATTATTAGTAACTTAGTCACCAATGCCATTAA
ATTCACTGACCATGGTTACGTGTTAGTCAGAACCAAAATTGAACAAGAAACCGATAAAGATTATACCCTTCTCATATCCA
TTAGTGATACAGGGATAGGAATTTCACAAGAAGATCAAAATAAACTGTTTACGGCATTCAATCAGGCCGATACCAGCATT
ACACGTCGCTATGGTGGTTCAGGTCTTGGCTTAGTCATCTGTAAAAAGCTATGTGAGCAAATGCATGGTCGGATTAGCCT
TAGCAGCGAGGTAAACAAAGGTTCAACCTTTAATGCACGTATTAAAGTTGAGAAATTGATGGCTTATGAAATTGAGAAGA
ATCAAATTCATCGATTTTCTCATCTAAAAATTATTTGTTTTGATGATCACTCTTTGCACTTGGAAGCCCTATGCAATGGT
CTTGGGTTTTGGGGTATTGAATGCGTTAAAGTGAATTCGTTTACCAACATCTCAAGCACCATTAATAAGCACAAGGAATG
CACCATTGTGTTTATGAATGTTAATCAAGGTTGTGAGCAACAAGCTGTCGAGCTCATTAAAAAACATCCAACCATGCCGT
TTGTGTTGATTTCAAAATGGCCTATTAACAATTATTCTGCATTAGGCGCTCGTGGTTTCTTATACAAACCCATCAGCATT
CAGAAACTCCAAGATCTTATAGAGTCAATCAATAATGAGAAAAAACCAGAAGATCACAGTGCACATGAGCTAGACGGATT
GAGAGAACAACTACGATATGTTCACCCTCATTTGTTGATTGCTGAAGACAATCCCGTCAACAAAATGCTGATAACCTCTT
TATTAAAAGAACAAGCGAACATCACCGCAGTCGATGATGGAGAAATGGCTGTTAAAGCCTGTGAAGAAACAAAGTTTGAT
GTCATTCTTCTTGATCTACAAATGCCTAAATTAGATGGGTTGCAAGCATCAAAATCCATACGTCAAAGTTCATTAATGAA
TAAACACACGCCTATTGTCCTCATCACAGCAAGCAGTAATGACTTAAATAATGCAGAGATGAAGCAATCCGGCATTGATC
TTTACCTGCAAAAACCAGTAGAAGAAAAGCAATTGTTAATTCAAATTTTGCGCATCATTAACAAATCCACCCATGCGGCT
ATTGACTGGGAGTTATGTGTTCAAAAGGTCTCAGGGAATCAAGCATTGGCTGAAGAATTTCTGGCAAAATTTATTGAAGA
GCTTTATAAGGCAAGAGATGAATTTATTCAATTAATGCATGATAAAAACATTCATAGTCTTGCGGATGCTGCTCACAAGC
TTCATGGAGCATGCTGTTTTTGTGGAGTCCCAGTTCTGCAAAAAAAAGTAACCCAATTTGAAAAACTAGCTAAACGAACC
AGTCATATTGATCACTTAAATGAAGCTTTCGCTGAATTAATTCAAAGCATTGATGCTGTAATTAACGAGTATGAAAATCA
GTATTCACACTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (409-524)

• His Kinase A (phospho-acceptor) domain (HisKA) (298-362)

• Response regulator receiver domain (Response_reg) (679-787)

• Hpt domain (Hpt) (819-902)

• Single cache domain 4 (sCache_4) (36-181)

3D structure

• AlphaFold DB: A0A0W1AMB6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
letS	Legionella pneumophila strain ERS1305867	83.626	100	0.836